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Article: Reference values of diffusing capacity of non-smoking Chinese in Hong Kong

TitleReference values of diffusing capacity of non-smoking Chinese in Hong Kong
Authors
Issue Date2007
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RES
Citation
Respirology, 2007, v. 12 n. 4, p. 599-606 How to Cite?
AbstractBackground and objective: This study was conducted to define normal reference values and lower limits of normal (LLN) for single-breath carbon monoxide diffusing capacity (DLco) and DLco per unit of alveolar volume (Kco) for Chinese adults in Hong Kong. Methods: Healthy non-smoking men and women aged 18-80 years were recruited by random digit dialling. DLco and Kco were measured according to American Thoracic Society standards. Reference equations were obtained by multiple linear regression; LLN were derived by distribution-free method for estimation of age-related centiles. Results: Tests from 568 subjects (259 men, 309 women) were analysed. DLco declined with age in both genders, and increased with height and the interaction term of height and age in men and women, respectively. Considering Hb values did not improve the reference equations. Kco declined with age and increased with weight in both genders, while height and its interaction term with age were additional determinants in women. The reference DLco was lower than some Caucasian values, and was only explained partially by a smaller body size and alveolar volume in Chinese. The distribution-free method yielded better overall approximation to the fifth percentile compared with the traditional method of determining LLN. Conclusions: The equations for reference values and LLN of diffusing capacity derived in this study are of clinical relevance to Chinese subjects. © 2007 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/77419
ISSN
2015 Impact Factor: 3.078
2015 SCImago Journal Rankings: 1.157
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorLai, AYKen_HK
dc.contributor.authorKo, FWSen_HK
dc.contributor.authorLau, ACWen_HK
dc.contributor.authorLing, SOen_HK
dc.contributor.authorChan, JWMen_HK
dc.contributor.authorChanYeung, MMWen_HK
dc.date.accessioned2010-09-06T07:31:41Z-
dc.date.available2010-09-06T07:31:41Z-
dc.date.issued2007en_HK
dc.identifier.citationRespirology, 2007, v. 12 n. 4, p. 599-606en_HK
dc.identifier.issn1323-7799en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77419-
dc.description.abstractBackground and objective: This study was conducted to define normal reference values and lower limits of normal (LLN) for single-breath carbon monoxide diffusing capacity (DLco) and DLco per unit of alveolar volume (Kco) for Chinese adults in Hong Kong. Methods: Healthy non-smoking men and women aged 18-80 years were recruited by random digit dialling. DLco and Kco were measured according to American Thoracic Society standards. Reference equations were obtained by multiple linear regression; LLN were derived by distribution-free method for estimation of age-related centiles. Results: Tests from 568 subjects (259 men, 309 women) were analysed. DLco declined with age in both genders, and increased with height and the interaction term of height and age in men and women, respectively. Considering Hb values did not improve the reference equations. Kco declined with age and increased with weight in both genders, while height and its interaction term with age were additional determinants in women. The reference DLco was lower than some Caucasian values, and was only explained partially by a smaller body size and alveolar volume in Chinese. The distribution-free method yielded better overall approximation to the fifth percentile compared with the traditional method of determining LLN. Conclusions: The equations for reference values and LLN of diffusing capacity derived in this study are of clinical relevance to Chinese subjects. © 2007 The Authors.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RESen_HK
dc.relation.ispartofRespirologyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAsian Continental Ancestry Groupen_HK
dc.subject.meshChina - ethnologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPulmonary Diffusing Capacityen_HK
dc.subject.meshReference Valuesen_HK
dc.titleReference values of diffusing capacity of non-smoking Chinese in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1323-7799&volume=12&spage=599&epage=606&date=2007&atitle=Reference+values+of+diffusing+capacity+of+non-smoking+Chinese+in+Hong+Kongen_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1843.2007.01084.xen_HK
dc.identifier.pmid17587430-
dc.identifier.scopuseid_2-s2.0-34250775471en_HK
dc.identifier.hkuros134891en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250775471&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue4en_HK
dc.identifier.spage599en_HK
dc.identifier.epage606en_HK
dc.identifier.isiWOS:000247440300021-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridLam, WK=37026410900en_HK
dc.identifier.scopusauthoridLai, AYK=25641477800en_HK
dc.identifier.scopusauthoridKo, FWS=7103224911en_HK
dc.identifier.scopusauthoridLau, ACW=7202626205en_HK
dc.identifier.scopusauthoridLing, SO=16642976900en_HK
dc.identifier.scopusauthoridChan, JWM=34967874700en_HK
dc.identifier.scopusauthoridChanYeung, MMW=54790582200en_HK
dc.identifier.citeulike1407639-

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