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Article: Pre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the rat

TitlePre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the rat
Authors
Issue Date2002
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 2002, v. 318 n. 3, p. 141-144 How to Cite?
AbstractWe investigated whether pre-treatment with melatonin, a potent free radical scavenger and antioxidant, would protect against permanent focal cerebral ischemia without reperfusion in a rat middle cerebral artery occlusion (MCAO) model. A single dose of melatonin at 5, 15, or 50 mg/kg or the vehicle alone was given via an intraperitoneal injection at 0.5 h before permanent MCAO. Relative infarction volumes on day 3 were significantly reduced in the groups treated with melatonin at 5 (mean ± SEM, 17.0 ± 6.5%), 15 (18.1 ± 5.8%), or 50 (20.6 ± 5.0%) mg/kg when compared with the vehicle-treated group (37.1 ± 2.8%) and so melatonin treatment achieved a relative reduction in infarct volume by 54.2, 51.2 and 44.5%, respectively. Melatonin did not affect the hemodynamic parameters. Thus, pre-treatment with melatonin at a dose between 5 and 50 mg/kg protects against focal cerebral ischemia without reperfusion. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/77417
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPei, Zen_HK
dc.contributor.authorHo, HTSen_HK
dc.contributor.authorCheung, RTFen_HK
dc.date.accessioned2010-09-06T07:31:40Z-
dc.date.available2010-09-06T07:31:40Z-
dc.date.issued2002en_HK
dc.identifier.citationNeuroscience Letters, 2002, v. 318 n. 3, p. 141-144en_HK
dc.identifier.issn0304-3940en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77417-
dc.description.abstractWe investigated whether pre-treatment with melatonin, a potent free radical scavenger and antioxidant, would protect against permanent focal cerebral ischemia without reperfusion in a rat middle cerebral artery occlusion (MCAO) model. A single dose of melatonin at 5, 15, or 50 mg/kg or the vehicle alone was given via an intraperitoneal injection at 0.5 h before permanent MCAO. Relative infarction volumes on day 3 were significantly reduced in the groups treated with melatonin at 5 (mean ± SEM, 17.0 ± 6.5%), 15 (18.1 ± 5.8%), or 50 (20.6 ± 5.0%) mg/kg when compared with the vehicle-treated group (37.1 ± 2.8%) and so melatonin treatment achieved a relative reduction in infarct volume by 54.2, 51.2 and 44.5%, respectively. Melatonin did not affect the hemodynamic parameters. Thus, pre-treatment with melatonin at a dose between 5 and 50 mg/kg protects against focal cerebral ischemia without reperfusion. © 2002 Elsevier Science Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_HK
dc.relation.ispartofNeuroscience Lettersen_HK
dc.rightsNeuroscience Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBlood Pressure - drug effects - physiologyen_HK
dc.subject.meshBrain - drug effects - pathology - physiopathologyen_HK
dc.subject.meshCerebral Infarction - drug therapy - pathology - physiopathologyen_HK
dc.subject.meshCerebrovascular Circulation - drug effects - physiologyen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshDrug Administration Scheduleen_HK
dc.subject.meshFree Radical Scavengers - pharmacologyen_HK
dc.subject.meshHeart Rate - drug effects - physiologyen_HK
dc.subject.meshInfarction, Middle Cerebral Artery - drug therapy - pathology - physiopathologyen_HK
dc.subject.meshLaser-Doppler Flowmetryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMelatonin - pharmacologyen_HK
dc.subject.meshNeuroprotective Agents - pharmacologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.titlePre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the raten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3940&volume=318&spage=141&epage=144&date=2002&atitle=Pre-treatment+with+melatonin+reduces+volume+of+cerebral+infarction+in+a+permanent+middle+cerebral+artery+occlusion+stroke+model+in+the+raten_HK
dc.identifier.emailCheung, RTF:rtcheung@hku.hken_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0304-3940(01)02503-4en_HK
dc.identifier.pmid11803119-
dc.identifier.scopuseid_2-s2.0-0036468920en_HK
dc.identifier.hkuros87783en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036468920&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume318en_HK
dc.identifier.issue3en_HK
dc.identifier.spage141en_HK
dc.identifier.epage144en_HK
dc.identifier.isiWOS:000173643600008-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridPei, Z=23051646800en_HK
dc.identifier.scopusauthoridHo, HTS=15740869700en_HK
dc.identifier.scopusauthoridCheung, RTF=7202397498en_HK

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