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Article: Effects of arsenic trioxide on the cellular proliferation, apoptosis and differentiation of human neuroblastoma cells

TitleEffects of arsenic trioxide on the cellular proliferation, apoptosis and differentiation of human neuroblastoma cells
Authors
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2007, v. 246 n. 1-2, p. 122-128 How to Cite?
AbstractA human neuroblastoma cell line, IMR-32, was used as an in vitro model system to study the effects of arsenic trioxide (As2O3) on aggressive human neuroblastoma. From 0.5 μM, As2O3 exhibited a dose-dependent inhibition of IMR-32 proliferation. At concentrations of 1.5 μM or higher, As2O3 up-regulated caspase 3, leading to cellular apoptosis. However, neurofilament-200 kDa and tyrosine hydroxylase were not up-regulated, implying minimal neuronal differentiation. Concomitantly, TrkA was down-regulated and TrkB up-regulated. Pre-treatment with the protein kinase C (PKC) inhibitor Ro-31-8220 partially blocked As2O3-mediated apoptosis, meaning that As2O3 might signal through PKC activation. The results suggest that As2O3 might be potentially useful in neuroblastoma. © 2006 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/77386
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, WMWen_HK
dc.contributor.authorChu, PWKen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:31:20Z-
dc.date.available2010-09-06T07:31:20Z-
dc.date.issued2007en_HK
dc.identifier.citationCancer Letters, 2007, v. 246 n. 1-2, p. 122-128en_HK
dc.identifier.issn0304-3835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77386-
dc.description.abstractA human neuroblastoma cell line, IMR-32, was used as an in vitro model system to study the effects of arsenic trioxide (As2O3) on aggressive human neuroblastoma. From 0.5 μM, As2O3 exhibited a dose-dependent inhibition of IMR-32 proliferation. At concentrations of 1.5 μM or higher, As2O3 up-regulated caspase 3, leading to cellular apoptosis. However, neurofilament-200 kDa and tyrosine hydroxylase were not up-regulated, implying minimal neuronal differentiation. Concomitantly, TrkA was down-regulated and TrkB up-regulated. Pre-treatment with the protein kinase C (PKC) inhibitor Ro-31-8220 partially blocked As2O3-mediated apoptosis, meaning that As2O3 might signal through PKC activation. The results suggest that As2O3 might be potentially useful in neuroblastoma. © 2006 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_HK
dc.relation.ispartofCancer Lettersen_HK
dc.rightsCancer Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subject.meshApoptosis - drug effectsen_HK
dc.subject.meshArsenicals - pharmacologyen_HK
dc.subject.meshBlotting, Westernen_HK
dc.subject.meshCell Differentiation - drug effectsen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshCell Proliferation - drug effectsen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshDown-Regulation - drug effectsen_HK
dc.subject.meshEnzyme Activation - drug effectsen_HK
dc.subject.meshGrowth Inhibitors - pharmacologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIndoles - pharmacologyen_HK
dc.subject.meshNeuroblastoma - enzymology - metabolism - pathologyen_HK
dc.subject.meshNeurofilament Proteins - metabolismen_HK
dc.subject.meshNeurons - drug effects - metabolism - pathologyen_HK
dc.subject.meshOxides - pharmacologyen_HK
dc.subject.meshProtein Kinase C - antagonists & inhibitors - metabolismen_HK
dc.subject.meshReceptor, trkA - metabolismen_HK
dc.subject.meshReceptor, trkB - metabolismen_HK
dc.subject.meshTyrosine 3-Monooxygenase - metabolismen_HK
dc.subject.meshUp-Regulation - drug effectsen_HK
dc.titleEffects of arsenic trioxide on the cellular proliferation, apoptosis and differentiation of human neuroblastoma cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3835&volume=&spage=&epage=&date=2006&atitle=Effects+of+arsenic+trioxide+on+the+cellular+proliferation,+apoptosis+and+differentiation+of+human+neuroblastoma+cellsen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2006.02.009en_HK
dc.identifier.pmid16569477-
dc.identifier.scopuseid_2-s2.0-33845634372en_HK
dc.identifier.hkuros116713en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845634372&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume246en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage122en_HK
dc.identifier.epage128en_HK
dc.identifier.isiWOS:000244154900015-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridCheung, WMW=7202743069en_HK
dc.identifier.scopusauthoridChu, PWK=7402159518en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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