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Article: Antirecipient helper and cytotoxic T-cell frequencies in bone marrow transplantation

TitleAntirecipient helper and cytotoxic T-cell frequencies in bone marrow transplantation
Authors
KeywordsCytotoxic T-lymphocytes precursor frequency
Graft-versus-host disease
Helper T-cell precursor frequency
IFN-γ-producing cell frequency
Limiting dilution assay
Issue Date2004
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
Citation
Bone Marrow Transplantation, 2004, v. 34 n. 3, p. 207-213 How to Cite?
AbstractWe assayed helper T-lymphocyte precursor frequencies (HTLPf), interferon (IFN)-γ-producing cell frequencies (IFN-γPf) and CTL precursor frequencies (CTLPf) to see if they could predict the severity of acute graft-versus-host disease (aGVHD) and disease relapse after transplantation. In all, 48 bone marrow transplantation (BMT) patients and their HLA-identical sibling (n = 29) or matched unrelated donors (MUD) (n = 19) were recruited. HTLPf, IFN-γPf and CTLPf were measured using a limiting dilution assay (LDA). Patients were followed prospectively to assess the severity of aGVHD and the status of the primary disease after BMT. High (>5 × 10-6) HTLPf, CTLPf and IFN-γPf were significantly associated with the occurrence and severity of aGVHD in patients who received transplants from HLA-identical sibling. Among patients receiving BMT from MUD, HTLPf and CTLPf, but not IFN-γPf, were associated with aGVHD. Five patients had disease relapse post-BMT and the risk was not significantly associated with HTLPf CTLPf or IFN-γPf. Patients with high (>5 × 10-6) HTLPf, IFN-γPf or CTLPf before BMT are at higher risk of developing aGVHD after transplantation from both matched sibling donors and MUD. Whether these parameters can predict disease relapse would have to be investigated with a larger cohort of patients. © 2004 Nature Publishing Group All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/77378
ISSN
2015 Impact Factor: 3.636
2015 SCImago Journal Rankings: 1.585
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwok, JSYen_HK
dc.contributor.authorLeung, AYHen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorChu, Pen_HK
dc.contributor.authorJones, Ben_HK
dc.contributor.authorHawkins, Ben_HK
dc.contributor.authorLiang, Ren_HK
dc.date.accessioned2010-09-06T07:31:15Z-
dc.date.available2010-09-06T07:31:15Z-
dc.date.issued2004en_HK
dc.identifier.citationBone Marrow Transplantation, 2004, v. 34 n. 3, p. 207-213en_HK
dc.identifier.issn0268-3369en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77378-
dc.description.abstractWe assayed helper T-lymphocyte precursor frequencies (HTLPf), interferon (IFN)-γ-producing cell frequencies (IFN-γPf) and CTL precursor frequencies (CTLPf) to see if they could predict the severity of acute graft-versus-host disease (aGVHD) and disease relapse after transplantation. In all, 48 bone marrow transplantation (BMT) patients and their HLA-identical sibling (n = 29) or matched unrelated donors (MUD) (n = 19) were recruited. HTLPf, IFN-γPf and CTLPf were measured using a limiting dilution assay (LDA). Patients were followed prospectively to assess the severity of aGVHD and the status of the primary disease after BMT. High (>5 × 10-6) HTLPf, CTLPf and IFN-γPf were significantly associated with the occurrence and severity of aGVHD in patients who received transplants from HLA-identical sibling. Among patients receiving BMT from MUD, HTLPf and CTLPf, but not IFN-γPf, were associated with aGVHD. Five patients had disease relapse post-BMT and the risk was not significantly associated with HTLPf CTLPf or IFN-γPf. Patients with high (>5 × 10-6) HTLPf, IFN-γPf or CTLPf before BMT are at higher risk of developing aGVHD after transplantation from both matched sibling donors and MUD. Whether these parameters can predict disease relapse would have to be investigated with a larger cohort of patients. © 2004 Nature Publishing Group All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmten_HK
dc.relation.ispartofBone Marrow Transplantationen_HK
dc.subjectCytotoxic T-lymphocytes precursor frequencyen_HK
dc.subjectGraft-versus-host diseaseen_HK
dc.subjectHelper T-cell precursor frequencyen_HK
dc.subjectIFN-γ-producing cell frequencyen_HK
dc.subjectLimiting dilution assayen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBone Marrow Transplantation - immunologyen_HK
dc.subject.meshChilden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGraft vs Host Disease - immunologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshT-Lymphocytes, Cytotoxic - immunologyen_HK
dc.subject.meshT-Lymphocytes, Helper-Inducer - immunologyen_HK
dc.titleAntirecipient helper and cytotoxic T-cell frequencies in bone marrow transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-3369&volume=34&issue=3&spage=207&epage=213&date=2004&atitle=Antirecipient+helper+and+cytotoxic+T-cell+frequencies+in+bone+marrow+transplantationen_HK
dc.identifier.emailLeung, AYH:ayhleung@hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authorityLeung, AYH=rp00265en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.bmt.1704566en_HK
dc.identifier.pmid15195076-
dc.identifier.scopuseid_2-s2.0-4344652822en_HK
dc.identifier.hkuros99041en_HK
dc.identifier.hkuros95096-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4344652822&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue3en_HK
dc.identifier.spage207en_HK
dc.identifier.epage213en_HK
dc.identifier.isiWOS:000222725800003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKwok, JSY=7006208874en_HK
dc.identifier.scopusauthoridLeung, AYH=7403012668en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridLee, TL=24483772800en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridChu, P=7402159699en_HK
dc.identifier.scopusauthoridJones, B=7404958958en_HK
dc.identifier.scopusauthoridHawkins, B=35944486200en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK

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