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Article: Cost-effectiveness of prenatal screening for thalassaemia in Hong Kong

TitleCost-effectiveness of prenatal screening for thalassaemia in Hong Kong
Authors
KeywordsCost effectiveness
Hong Kong
Prenatal screening
Thalassaemia
Issue Date2004
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2004, v. 24 n. 11, p. 899-907 How to Cite?
AbstractObjectives: To determine the cost effectiveness of a universal prenatal screening program for α- and β-thalassaemia. Methods: We retrospectively reviewed our program from 1998 to 2002, and calculated the direct and indirect costs of various components. Results 18 936 women were screened at our prenatal clinic and 153 couples were subsequently referred to our Prenatal Diagnostic Centre for counselling and further investigations. In addition, there were 238 tertiary referrals and 157 self-referrals. After investigations, 84 fetuses were at risk of β-thalassaemia major/β-E thalassaemia, 19 of them were affected and 18 were aborted. The total expenditure on our program (HK$ 10.0 million) would be less than the postnatal service costs (HK$ 40.4 million) for 18β-thalassaemia major fetuses if they were born. Of 361 women at risk of carrying a homozygous α0-thalassaemia fetus, 311 (86.2%) opted for the indirect approach (using serial ultrasound examinations to exclude Hb Bart's disease), and 76 (24.5%) subsequently underwent an invasive test for a definitive diagnosis. The sensitivity and false positive rate of this indirect approach was 100.0% and 2.9% respectively. Conclusion It is cost effective to run a universal prenatal screening program in an area where both thalassaemia and α-thalassaemia are prevalent. The indirect approach can effectively avoid an invasive test in unaffected pregnancies. Copyright © 2004 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/77364
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, KYen_HK
dc.contributor.authorLee, CPen_HK
dc.contributor.authorTang, MHYen_HK
dc.contributor.authorLau, ETen_HK
dc.contributor.authorNg, LKLen_HK
dc.contributor.authorLee, YPen_HK
dc.contributor.authorChan, HYen_HK
dc.contributor.authorMa, ESKen_HK
dc.contributor.authorChan, Ven_HK
dc.date.accessioned2010-09-06T07:31:06Z-
dc.date.available2010-09-06T07:31:06Z-
dc.date.issued2004en_HK
dc.identifier.citationPrenatal Diagnosis, 2004, v. 24 n. 11, p. 899-907en_HK
dc.identifier.issn0197-3851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77364-
dc.description.abstractObjectives: To determine the cost effectiveness of a universal prenatal screening program for α- and β-thalassaemia. Methods: We retrospectively reviewed our program from 1998 to 2002, and calculated the direct and indirect costs of various components. Results 18 936 women were screened at our prenatal clinic and 153 couples were subsequently referred to our Prenatal Diagnostic Centre for counselling and further investigations. In addition, there were 238 tertiary referrals and 157 self-referrals. After investigations, 84 fetuses were at risk of β-thalassaemia major/β-E thalassaemia, 19 of them were affected and 18 were aborted. The total expenditure on our program (HK$ 10.0 million) would be less than the postnatal service costs (HK$ 40.4 million) for 18β-thalassaemia major fetuses if they were born. Of 361 women at risk of carrying a homozygous α0-thalassaemia fetus, 311 (86.2%) opted for the indirect approach (using serial ultrasound examinations to exclude Hb Bart's disease), and 76 (24.5%) subsequently underwent an invasive test for a definitive diagnosis. The sensitivity and false positive rate of this indirect approach was 100.0% and 2.9% respectively. Conclusion It is cost effective to run a universal prenatal screening program in an area where both thalassaemia and α-thalassaemia are prevalent. The indirect approach can effectively avoid an invasive test in unaffected pregnancies. Copyright © 2004 John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_HK
dc.relation.ispartofPrenatal Diagnosisen_HK
dc.rightsPrenatal Diagnosis. Copyright © John Wiley & Sons Ltd.en_HK
dc.subjectCost effectivenessen_HK
dc.subjectHong Kongen_HK
dc.subjectPrenatal screeningen_HK
dc.subjectThalassaemiaen_HK
dc.subject.meshCost-Benefit Analysisen_HK
dc.subject.meshDecision Treesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMedical Recordsen_HK
dc.subject.meshOutcome Assessment (Health Care)en_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshPrenatal Diagnosis - economics - methodsen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshThalassemia - blood - diagnosisen_HK
dc.subject.meshalpha-Thalassemia - blood - diagnosisen_HK
dc.subject.meshbeta-Thalassemia - blood - diagnosisen_HK
dc.titleCost-effectiveness of prenatal screening for thalassaemia in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0197-3851&volume=24&spage=899&epage=907&date=2004&atitle=Cost-effectiveness+of+prenatal+screening+for+thalassaemia+in+Hong+Kongen_HK
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_HK
dc.identifier.emailChan, V: vnychana@hkucc.hku.hken_HK
dc.identifier.authorityTang, MHY=rp01701en_HK
dc.identifier.authorityChan, V=rp00320en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/pd.1035en_HK
dc.identifier.pmid15565640-
dc.identifier.scopuseid_2-s2.0-9644252847en_HK
dc.identifier.hkuros96836en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-9644252847&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue11en_HK
dc.identifier.spage899en_HK
dc.identifier.epage907en_HK
dc.identifier.isiWOS:000225455800011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLeung, KY=8247106900en_HK
dc.identifier.scopusauthoridLee, CP=7410149538en_HK
dc.identifier.scopusauthoridTang, MHY=8943401300en_HK
dc.identifier.scopusauthoridLau, ET=7103086081en_HK
dc.identifier.scopusauthoridNg, LKL=25630698100en_HK
dc.identifier.scopusauthoridLee, YP=15033545100en_HK
dc.identifier.scopusauthoridChan, HY=7403402562en_HK
dc.identifier.scopusauthoridMa, ESK=7202039934en_HK
dc.identifier.scopusauthoridChan, V=7202654865en_HK

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