File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Large granular lymphocyte leukemia: A study of nine cases in a Chinese population

TitleLarge granular lymphocyte leukemia: A study of nine cases in a Chinese population
Authors
KeywordsCD56
Granular lymphocytes
Leukemia
Lymphoproliferative diseases
Issue Date1995
PublisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.com
Citation
American Journal Of Clinical Pathology, 1995, v. 103 n. 1, p. 76-81 How to Cite?
AbstractLarge granular lymphocyte (LGL) leukemia is a neoplastic disorder of lymphocytes that is characterized by the presence of prominent cytoplasmic granules, and involves the proliferation of at least two distinct cell types, T cells and natural killer (NK) cells. The authors report the clinical and pathologic features of 9 Chinese patients with LGL leukemia, who represented 14% of 64 cases of chronic lymphoproliferative disorders diagnosed at their centers in 3 years. Three different groups could be defined on immunophenotypic and clinical grounds. The first group of 4 cases were CD2+CD3+CD4-CD8+. With the exception of a pediatric case, these cases ran an indolent course that was similar to the T-cell LGL leukemia most common in Western patients. However, thrombocytopenia and pure red cell aplasia were more common in the patients in this study, which was similar to the experience in Japanese patients. The second group of two cases were CD2+CD3+CD4+CD8-, and appeared to have worse outcomes than the first group. The third group of 3 cases were CD2+CD3-CD4-CD8-CD56+. Although phenotypically similar to the NK-cell LGL leukemia reported in Western patients, these cases were clinically more aggressive than their Western counterparts. This study is the first to report comprehensively the different types of LGL leukemias in Chinese patients, and provides useful information on the similarities and differences of these disorders as compared to those cases in the West.
Persistent Identifierhttp://hdl.handle.net/10722/77344
ISSN
2015 Impact Factor: 2.278
2015 SCImago Journal Rankings: 1.129
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorWong, KFen_HK
dc.contributor.authorChan, LCen_HK
dc.contributor.authorLiang, RHSen_HK
dc.contributor.authorChan, JKCen_HK
dc.contributor.authorLin, CKen_HK
dc.contributor.authorChan, TKen_HK
dc.date.accessioned2010-09-06T07:30:54Z-
dc.date.available2010-09-06T07:30:54Z-
dc.date.issued1995en_HK
dc.identifier.citationAmerican Journal Of Clinical Pathology, 1995, v. 103 n. 1, p. 76-81en_HK
dc.identifier.issn0002-9173en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77344-
dc.description.abstractLarge granular lymphocyte (LGL) leukemia is a neoplastic disorder of lymphocytes that is characterized by the presence of prominent cytoplasmic granules, and involves the proliferation of at least two distinct cell types, T cells and natural killer (NK) cells. The authors report the clinical and pathologic features of 9 Chinese patients with LGL leukemia, who represented 14% of 64 cases of chronic lymphoproliferative disorders diagnosed at their centers in 3 years. Three different groups could be defined on immunophenotypic and clinical grounds. The first group of 4 cases were CD2+CD3+CD4-CD8+. With the exception of a pediatric case, these cases ran an indolent course that was similar to the T-cell LGL leukemia most common in Western patients. However, thrombocytopenia and pure red cell aplasia were more common in the patients in this study, which was similar to the experience in Japanese patients. The second group of two cases were CD2+CD3+CD4+CD8-, and appeared to have worse outcomes than the first group. The third group of 3 cases were CD2+CD3-CD4-CD8-CD56+. Although phenotypically similar to the NK-cell LGL leukemia reported in Western patients, these cases were clinically more aggressive than their Western counterparts. This study is the first to report comprehensively the different types of LGL leukemias in Chinese patients, and provides useful information on the similarities and differences of these disorders as compared to those cases in the West.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.comen_HK
dc.relation.ispartofAmerican Journal of Clinical Pathologyen_HK
dc.subjectCD56en_HK
dc.subjectGranular lymphocytesen_HK
dc.subjectLeukemiaen_HK
dc.subjectLymphoproliferative diseasesen_HK
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAsian Continental Ancestry Group-
dc.subject.meshCytoplasmic Granules - ultrastructure-
dc.subject.meshLeukemia, Lymphoid - ethnology - pathology - therapy-
dc.titleLarge granular lymphocyte leukemia: A study of nine cases in a Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9173&volume=103&issue=1&spage=76&epage=81&date=1995&atitle=Large+granular+lymphocyte+leukemia:+a+study+of+nine+cases+in+a+Chinese+populationen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.emailLiang, RHS:rliang@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.identifier.authorityLiang, RHS=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7817949en_HK
dc.identifier.scopuseid_2-s2.0-0028851244en_HK
dc.identifier.hkuros6135en_HK
dc.identifier.volume103en_HK
dc.identifier.issue1en_HK
dc.identifier.spage76en_HK
dc.identifier.epage81en_HK
dc.identifier.isiWOS:A1995QA35300016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridWong, KF=7404759860en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK
dc.identifier.scopusauthoridLiang, RHS=26643224900en_HK
dc.identifier.scopusauthoridChan, JKC=7403287069en_HK
dc.identifier.scopusauthoridLin, CK=15034856400en_HK
dc.identifier.scopusauthoridChan, TK=7402687762en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats