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Article: A prospective study of respiratory ciliary structure and function after stem cell transplantation

TitleA prospective study of respiratory ciliary structure and function after stem cell transplantation
Authors
Issue Date2006
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
Citation
Bone Marrow Transplantation, 2006, v. 38 n. 3, p. 243-248 How to Cite?
AbstractWe prospectively investigated the morphological and ciliary function abnormalities in 19 consecutive Chinese patients undergoing hemopoietic stem cell transplantation (HSCT) and studied their relationship with pulmonary complications. The percentage of structural ciliary abnormalities preceding HSCT was comparable to normal controls, but increased up to 1-year post-HSCT. However, the abnormalities did not correlate with ciliary or pulmonary function. Ciliary beat frequency (CBF) for patients undergoing autologous and allogeneic SCT was lower than that of matched controls, with a further decline at one year. There was, however, no significant change in pulmonary function for the whole cohort. There was considerable variation in CBF and ciliary abnormalities in all cases during 3-month interval assessments. Regular ciliary assessment did not predict the only two patients who eventually suffered from bronchiolitis obliterans (BO). We conclude that structural and functional ciliary abnormalities are common in recipients of HSCT, and predict post-HSCT deterioration. However, there is no evidence to show that CBF monitoring may be of prospective benefit. © Nature Publishing Group. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/77335
ISSN
2014 Impact Factor: 3.570
2013 SCImago Journal Rankings: 1.441
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorHo, JCen_HK
dc.contributor.authorLie, AKen_HK
dc.contributor.authorSun, Jen_HK
dc.contributor.authorZheng, Len_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorTsang, KWen_HK
dc.date.accessioned2010-09-06T07:30:48Z-
dc.date.available2010-09-06T07:30:48Z-
dc.date.issued2006en_HK
dc.identifier.citationBone Marrow Transplantation, 2006, v. 38 n. 3, p. 243-248en_HK
dc.identifier.issn0268-3369en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77335-
dc.description.abstractWe prospectively investigated the morphological and ciliary function abnormalities in 19 consecutive Chinese patients undergoing hemopoietic stem cell transplantation (HSCT) and studied their relationship with pulmonary complications. The percentage of structural ciliary abnormalities preceding HSCT was comparable to normal controls, but increased up to 1-year post-HSCT. However, the abnormalities did not correlate with ciliary or pulmonary function. Ciliary beat frequency (CBF) for patients undergoing autologous and allogeneic SCT was lower than that of matched controls, with a further decline at one year. There was, however, no significant change in pulmonary function for the whole cohort. There was considerable variation in CBF and ciliary abnormalities in all cases during 3-month interval assessments. Regular ciliary assessment did not predict the only two patients who eventually suffered from bronchiolitis obliterans (BO). We conclude that structural and functional ciliary abnormalities are common in recipients of HSCT, and predict post-HSCT deterioration. However, there is no evidence to show that CBF monitoring may be of prospective benefit. © Nature Publishing Group. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmten_HK
dc.relation.ispartofBone Marrow Transplantationen_HK
dc.subject.meshAdulten_HK
dc.subject.meshBronchiolitis Obliterans - pathology - physiopathologyen_HK
dc.subject.meshCilia - physiology - ultrastructureen_HK
dc.subject.meshCiliary Motility Disorders - drug therapy - pathology - physiopathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGraft vs Host Diseaseen_HK
dc.subject.meshHematopoietic Stem Cell Transplantation - adverse effectsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicroscopy, Electron, Transmissionen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshRespiratory Function Tests - methodsen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleA prospective study of respiratory ciliary structure and function after stem cell transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-3369&volume=38&spage=243&epage=248&date=2006&atitle=A+prospective+study+of+respiratory+ciliary+structure+and+function+after+stem+cell+transplantationen_HK
dc.identifier.emailHo, JC:jhocm@hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authorityHo, JC=rp00258en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.bmt.1705430en_HK
dc.identifier.pmid16850034en_HK
dc.identifier.scopuseid_2-s2.0-33746284258en_HK
dc.identifier.hkuros131113en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746284258&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue3en_HK
dc.identifier.spage243en_HK
dc.identifier.epage248en_HK
dc.identifier.isiWOS:000239118600012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridHo, JC=7402649981en_HK
dc.identifier.scopusauthoridLie, AK=24284842400en_HK
dc.identifier.scopusauthoridSun, J=7410371598en_HK
dc.identifier.scopusauthoridZheng, L=7403404086en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridTsang, KW=7201555024en_HK

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