Article: A prospective study of respiratory ciliary structure and function after stem cell transplantation

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TitleA prospective study of respiratory ciliary structure and function after stem cell transplantation
AuthorsAu, WY1
Ho, JC1
Lie, AK1
Sun, J1
Zheng, L1
Liang, R1
Lam, WK1
Tsang, KW1
Issue Date2006
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
CitationBone Marrow Transplantation, 2006, v. 38 n. 3, p. 243-248 [How to Cite?]
DOI: http://dx.doi.org/10.1038/sj.bmt.1705430
AbstractWe prospectively investigated the morphological and ciliary function abnormalities in 19 consecutive Chinese patients undergoing hemopoietic stem cell transplantation (HSCT) and studied their relationship with pulmonary complications. The percentage of structural ciliary abnormalities preceding HSCT was comparable to normal controls, but increased up to 1-year post-HSCT. However, the abnormalities did not correlate with ciliary or pulmonary function. Ciliary beat frequency (CBF) for patients undergoing autologous and allogeneic SCT was lower than that of matched controls, with a further decline at one year. There was, however, no significant change in pulmonary function for the whole cohort. There was considerable variation in CBF and ciliary abnormalities in all cases during 3-month interval assessments. Regular ciliary assessment did not predict the only two patients who eventually suffered from bronchiolitis obliterans (BO). We conclude that structural and functional ciliary abnormalities are common in recipients of HSCT, and predict post-HSCT deterioration. However, there is no evidence to show that CBF monitoring may be of prospective benefit. © Nature Publishing Group. All rights reserved.
ISSN0268-3369
2011 Impact Factor: 3.746
2011 SCImago Journal Rankings: 0.315
DOIhttp://dx.doi.org/10.1038/sj.bmt.1705430
ISI Accession Number IDWOS:000239118600012
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorAu, WY
dc.contributor.authorHo, JC
dc.contributor.authorLie, AK
dc.contributor.authorSun, J
dc.contributor.authorZheng, L
dc.contributor.authorLiang, R
dc.contributor.authorLam, WK
dc.contributor.authorTsang, KW
dc.date.accessioned2010-09-06T07:30:48Z
dc.date.available2010-09-06T07:30:48Z
dc.date.issued2006
dc.description.abstractWe prospectively investigated the morphological and ciliary function abnormalities in 19 consecutive Chinese patients undergoing hemopoietic stem cell transplantation (HSCT) and studied their relationship with pulmonary complications. The percentage of structural ciliary abnormalities preceding HSCT was comparable to normal controls, but increased up to 1-year post-HSCT. However, the abnormalities did not correlate with ciliary or pulmonary function. Ciliary beat frequency (CBF) for patients undergoing autologous and allogeneic SCT was lower than that of matched controls, with a further decline at one year. There was, however, no significant change in pulmonary function for the whole cohort. There was considerable variation in CBF and ciliary abnormalities in all cases during 3-month interval assessments. Regular ciliary assessment did not predict the only two patients who eventually suffered from bronchiolitis obliterans (BO). We conclude that structural and functional ciliary abnormalities are common in recipients of HSCT, and predict post-HSCT deterioration. However, there is no evidence to show that CBF monitoring may be of prospective benefit. © Nature Publishing Group. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationBone Marrow Transplantation, 2006, v. 38 n. 3, p. 243-248 [How to Cite?]
DOI: http://dx.doi.org/10.1038/sj.bmt.1705430
dc.identifier.doihttp://dx.doi.org/10.1038/sj.bmt.1705430
dc.identifier.epage248
dc.identifier.hkuros131113
dc.identifier.isiWOS:000239118600012
dc.identifier.issn0268-3369
2011 Impact Factor: 3.746
2011 SCImago Journal Rankings: 0.315
dc.identifier.issue3
dc.identifier.openurl
dc.identifier.pmid16850034
dc.identifier.scopuseid_2-s2.0-33746284258
dc.identifier.spage243
dc.identifier.urihttp://hdl.handle.net/10722/77335
dc.identifier.volume38
dc.languageeng
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
dc.publisher.placeUnited Kingdom
dc.relation.ispartofBone Marrow Transplantation
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshBronchiolitis Obliterans - pathology - physiopathology
dc.subject.meshCilia - physiology - ultrastructure
dc.subject.meshCiliary Motility Disorders - drug therapy - pathology - physiopathology
dc.subject.meshFemale
dc.subject.meshGraft vs Host Disease
dc.subject.meshHematopoietic Stem Cell Transplantation - adverse effects
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMicroscopy, Electron, Transmission
dc.subject.meshMiddle Aged
dc.subject.meshProspective Studies
dc.subject.meshRespiratory Function Tests - methods
dc.subject.meshTreatment Outcome
dc.titleA prospective study of respiratory ciliary structure and function after stem cell transplantation
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong