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Article: Electrophysiologic actions of dl-sotalol in patients with persistent atrial fibrillation

TitleElectrophysiologic actions of dl-sotalol in patients with persistent atrial fibrillation
Authors
Issue Date2002
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jac
Citation
Journal Of The American College Of Cardiology, 2002, v. 40 n. 12, p. 2150-2155 How to Cite?
AbstractOBJECTIVES: We sought to determine the electrophysiologic actions of sotalol in the remodeled atrium of humans. BACKGROUND: In experimental studies, sotalol has limited class III action in the electrically remodeled atrium and did not prevent atrial fibrillation (AF) induction. METHODS: We determined the effective refractory periods (ERPs) at three pacing cycle lengths (400, 500, and 600 ms) in the high right atrium (HRA) and distal coronary sinus (DCS) before and after intravenous infusion of dl-sotalol in 10 patients with persistent AF who underwent internal cardioversion. The same protocols were performed in 10 control subjects in sinus rhythm. RESULTS: In the HRA and DCS, the atrial ERPs at different drive cycle lengths were significantly shorter in patients with AF than in control subjects (p < 0.05). In patients with AF, the atrial ERP's adaptation to rate was nearly normal in the HRA, but was poor in the DCS. In both groups, dl-sotalol significantly increased the atrial ERPs at both the HRA and DCS, as compared with baseline (p < 0.05). However, the prolongation of atrial ERPs was significantly less at a drive cycle length of 600 ms in patients with AF versus control subjects (p < 0.05). After infusion of dl-sotalol, the atrial ERP's adaptation to rate at both the HRA and DCS was poor in patients with AF, and AF was still easily inducible in the majority of them, but not in control subjects. CONCLUSIONS: The results of the present study demonstrate that the electrophysiologic actions of dl-sotalol are significantly attenuated in the chronically remodeled human atrium, and these changes might represent a probable explanation for the low efficacy of dl-sotalol to prevent early AF recurrence after electrical cardioversion. © 2002 by the American College of Cardiology Foundation.
Persistent Identifierhttp://hdl.handle.net/10722/77291
ISSN
2015 Impact Factor: 17.759
2015 SCImago Journal Rankings: 10.097
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, HFen_HK
dc.contributor.authorLau, CPen_HK
dc.date.accessioned2010-09-06T07:30:19Z-
dc.date.available2010-09-06T07:30:19Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of The American College Of Cardiology, 2002, v. 40 n. 12, p. 2150-2155en_HK
dc.identifier.issn0735-1097en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77291-
dc.description.abstractOBJECTIVES: We sought to determine the electrophysiologic actions of sotalol in the remodeled atrium of humans. BACKGROUND: In experimental studies, sotalol has limited class III action in the electrically remodeled atrium and did not prevent atrial fibrillation (AF) induction. METHODS: We determined the effective refractory periods (ERPs) at three pacing cycle lengths (400, 500, and 600 ms) in the high right atrium (HRA) and distal coronary sinus (DCS) before and after intravenous infusion of dl-sotalol in 10 patients with persistent AF who underwent internal cardioversion. The same protocols were performed in 10 control subjects in sinus rhythm. RESULTS: In the HRA and DCS, the atrial ERPs at different drive cycle lengths were significantly shorter in patients with AF than in control subjects (p < 0.05). In patients with AF, the atrial ERP's adaptation to rate was nearly normal in the HRA, but was poor in the DCS. In both groups, dl-sotalol significantly increased the atrial ERPs at both the HRA and DCS, as compared with baseline (p < 0.05). However, the prolongation of atrial ERPs was significantly less at a drive cycle length of 600 ms in patients with AF versus control subjects (p < 0.05). After infusion of dl-sotalol, the atrial ERP's adaptation to rate at both the HRA and DCS was poor in patients with AF, and AF was still easily inducible in the majority of them, but not in control subjects. CONCLUSIONS: The results of the present study demonstrate that the electrophysiologic actions of dl-sotalol are significantly attenuated in the chronically remodeled human atrium, and these changes might represent a probable explanation for the low efficacy of dl-sotalol to prevent early AF recurrence after electrical cardioversion. © 2002 by the American College of Cardiology Foundation.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jacen_HK
dc.relation.ispartofJournal of the American College of Cardiologyen_HK
dc.rightsJournal of American College of Cardiology. Copyright © Elsevier Inc.en_HK
dc.subject.meshAgeden_HK
dc.subject.meshAnti-Arrhythmia Agents - pharmacology - therapeutic useen_HK
dc.subject.meshAtrial Fibrillation - drug therapy - physiopathologyen_HK
dc.subject.meshAtrial Function - drug effectsen_HK
dc.subject.meshCardiac Pacing, Artificialen_HK
dc.subject.meshElectric Countershocken_HK
dc.subject.meshElectrophysiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHeart Atria - drug effects - physiopathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshSotalol - pharmacology - therapeutic useen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleElectrophysiologic actions of dl-sotalol in patients with persistent atrial fibrillationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0735-1097&volume=40 &issue=12&spage=2150&epage=5&date=2002&atitle=Electrophysiologic+Actions+of+dl-sotalol+in+Patients+with+Persistent+Atrial+Fibrillation.en_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0735-1097(02)02592-5en_HK
dc.identifier.pmid12505228-
dc.identifier.scopuseid_2-s2.0-0037132680en_HK
dc.identifier.hkuros81899en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037132680&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue12en_HK
dc.identifier.spage2150en_HK
dc.identifier.epage2155en_HK
dc.identifier.isiWOS:000179834600014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK

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