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Article: Successful treatment of thrombotic microangiopathy after haematopoietic stem cell transplantation with rituximab

TitleSuccessful treatment of thrombotic microangiopathy after haematopoietic stem cell transplantation with rituximab
Authors
Issue Date2007
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2007, v. 137 n. 5, p. 475-478 How to Cite?
AbstractThrombotic microangiopathy (TMA) is a grave complication after haematopoietic stem cell transplantation (HSCT) and effective treatment is undefined. Five patients with postHSCT TMA, which was refractory to at least 1 week of plasma exchange and prednisolone, were treated with rituximab (375 mg/m 2/week × 4). Remission was achieved in four patients, of whom three remained in remission and one had died of sepsis at a median follow-up of 10 months. ADAMTS13 levels were low in all evaluable patients, and only one patient showed significant anti-ADAMTS13 antibody. The levels of ADAMTS13 and anti-ADAMTS13 antibody did not change significantly with rituximab-induced remission. © 2007 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/77287
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorMa, ESen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorFung, ATen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:30:16Z-
dc.date.available2010-09-06T07:30:16Z-
dc.date.issued2007en_HK
dc.identifier.citationBritish Journal Of Haematology, 2007, v. 137 n. 5, p. 475-478en_HK
dc.identifier.issn0007-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77287-
dc.description.abstractThrombotic microangiopathy (TMA) is a grave complication after haematopoietic stem cell transplantation (HSCT) and effective treatment is undefined. Five patients with postHSCT TMA, which was refractory to at least 1 week of plasma exchange and prednisolone, were treated with rituximab (375 mg/m 2/week × 4). Remission was achieved in four patients, of whom three remained in remission and one had died of sepsis at a median follow-up of 10 months. ADAMTS13 levels were low in all evaluable patients, and only one patient showed significant anti-ADAMTS13 antibody. The levels of ADAMTS13 and anti-ADAMTS13 antibody did not change significantly with rituximab-induced remission. © 2007 The Authors.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_HK
dc.relation.ispartofBritish Journal of Haematologyen_HK
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshADAM Proteins - immunologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAntibodies, Monoclonal - therapeutic useen_HK
dc.subject.meshAntibodies, Monoclonal, Murine-Deriveden_HK
dc.subject.meshAutoantigens - blooden_HK
dc.subject.meshBiological Markers - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGlucocorticoids - therapeutic useen_HK
dc.subject.meshHematopoietic Stem Cell Transplantation - adverse effectsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunologic Factors - therapeutic useen_HK
dc.subject.meshInfanten_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicrocirculationen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPlasma Exchangeen_HK
dc.subject.meshPrednisolone - therapeutic useen_HK
dc.subject.meshRemission Inductionen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshThrombosis - drug therapy - etiology - therapyen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleSuccessful treatment of thrombotic microangiopathy after haematopoietic stem cell transplantation with rituximaben_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1048&volume=137&spage=475&epage=478&date=2007&atitle=Successful+treatment+of+thrombotic+microangiopathy+after+haematopoietic+stem+cell+transplantation+with+rituximaben_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2141.2007.06588.xen_HK
dc.identifier.pmid17433026-
dc.identifier.scopuseid_2-s2.0-34247895387en_HK
dc.identifier.hkuros126716en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247895387&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume137en_HK
dc.identifier.issue5en_HK
dc.identifier.spage475en_HK
dc.identifier.epage478en_HK
dc.identifier.isiWOS:000246186800013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridMa, ES=7202039934en_HK
dc.identifier.scopusauthoridLee, TL=8508917400en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridFung, AT=7101926728en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.citeulike1279611-

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