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Article: Peripheral neuropathy in systemic lupus erythematosus

TitlePeripheral neuropathy in systemic lupus erythematosus
Authors
Issue Date1999
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.clinicalneurophys.com
Citation
Journal Of Clinical Neurophysiology, 1999, v. 16 n. 2, p. 164-168 How to Cite?
AbstractThe prevalence of clinically apparent peripheral neuropathy in systemic lupus erythematosus is reported to be between 2% to 18%. The purpose of this prospective case-control study was to determine the prevalence of peripheral neuropathy (PN) using electrodiagnostic criteria. Subgroup analysis was performed to determine whether PN correlated with disease activity, renal involvement, or serum immune markers. Fifty-four systemic lupus erythematosus patients and 30 controls were recruited in the study. The right median, ulnar, peroneal, tibial, and sural sensory and motor nerve conduction studies were obtained. PN in our study was defined as any abnormal values in motor and sensory distal latency, sensory action potential, motor action potential, or conduction velocity affecting 2 or more nerves. Of the 54 patients studied, PN was present in 15 patients (27.8%) of which 4 were symptomatic. There was a significant correlation between PN and anti-SM antibody, and there was a trend showing decreased motor and sensory action potential amplitudes in our systemic lupus erythematosus group compared to the controls. This observation was also seen in an active disease group when compared to those with inactive disease. The amplitude of the action potential was more often affected than the distal latency, and sensory nerves were more susceptible than motor nerves. The sural sensory action potential amplitude appears to be the most sensitive indicator of PN which may be used as an index to monitor disease activity.
Persistent Identifierhttp://hdl.handle.net/10722/77240
ISSN
2015 Impact Factor: 1.337
2015 SCImago Journal Rankings: 0.578
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuynh, Cen_HK
dc.contributor.authorHo, SLen_HK
dc.contributor.authorFong, KYen_HK
dc.contributor.authorCheung, RTFen_HK
dc.contributor.authorMok, CCen_HK
dc.contributor.authorLau, CSen_HK
dc.date.accessioned2010-09-06T07:29:46Z-
dc.date.available2010-09-06T07:29:46Z-
dc.date.issued1999en_HK
dc.identifier.citationJournal Of Clinical Neurophysiology, 1999, v. 16 n. 2, p. 164-168en_HK
dc.identifier.issn0736-0258en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77240-
dc.description.abstractThe prevalence of clinically apparent peripheral neuropathy in systemic lupus erythematosus is reported to be between 2% to 18%. The purpose of this prospective case-control study was to determine the prevalence of peripheral neuropathy (PN) using electrodiagnostic criteria. Subgroup analysis was performed to determine whether PN correlated with disease activity, renal involvement, or serum immune markers. Fifty-four systemic lupus erythematosus patients and 30 controls were recruited in the study. The right median, ulnar, peroneal, tibial, and sural sensory and motor nerve conduction studies were obtained. PN in our study was defined as any abnormal values in motor and sensory distal latency, sensory action potential, motor action potential, or conduction velocity affecting 2 or more nerves. Of the 54 patients studied, PN was present in 15 patients (27.8%) of which 4 were symptomatic. There was a significant correlation between PN and anti-SM antibody, and there was a trend showing decreased motor and sensory action potential amplitudes in our systemic lupus erythematosus group compared to the controls. This observation was also seen in an active disease group when compared to those with inactive disease. The amplitude of the action potential was more often affected than the distal latency, and sensory nerves were more susceptible than motor nerves. The sural sensory action potential amplitude appears to be the most sensitive indicator of PN which may be used as an index to monitor disease activity.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.clinicalneurophys.comen_HK
dc.relation.ispartofJournal of Clinical Neurophysiologyen_HK
dc.rightsJournal of Clinical Neurophysiology. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshElectromyographyen_HK
dc.subject.meshEvoked Potentials, Motor - physiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHereditary Sensory and Autonomic Neuropathies - blood - diagnosisen_HK
dc.subject.meshHereditary Sensory and Motor Neuropathy - blood - diagnosisen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLupus Erythematosus, Systemic - blood - complicationsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshProspective Studiesen_HK
dc.titlePeripheral neuropathy in systemic lupus erythematosusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0736-0258&volume=16&issue=2&spage=164&epage=168&date=1999&atitle=Peripheral+neuropathy+in+systemic+lupus+erythematosusen_HK
dc.identifier.emailHo, SL:slho@hku.hken_HK
dc.identifier.emailCheung, RTF:rtcheung@hku.hken_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.authorityHo, SL=rp00240en_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00004691-199903000-00010en_HK
dc.identifier.pmid10359503-
dc.identifier.scopuseid_2-s2.0-0032956330en_HK
dc.identifier.hkuros42997en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032956330&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue2en_HK
dc.identifier.spage164en_HK
dc.identifier.epage168en_HK
dc.identifier.isiWOS:000080527800010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHuynh, C=7005973079en_HK
dc.identifier.scopusauthoridHo, SL=25959633500en_HK
dc.identifier.scopusauthoridFong, KY=8913866800en_HK
dc.identifier.scopusauthoridCheung, RTF=7202397498en_HK
dc.identifier.scopusauthoridMok, CC=34668219600en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK

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