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Article: High incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer disease

TitleHigh incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer disease
Authors
Issue Date2003
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 2003, v. 18 n. 4, p. 443-449 How to Cite?
Abstract
Background: In average-risk patients, the new antiplatelet agent, clopidogrel, causes less upper gastrointestinal adverse events than aspirin. However, there are no safety data on the use of clopidogrel in high-risk patients. Aim: To evaluate the safety of clopidogrel in patients with peptic ulcer disease in a retrospective cohort longitudinal study. Methods: During the period from January 2000 to May 2002, 70 patients who were prescribed clopidogrel (75 mg/day) for a previous history of non-aspirin-related peptic ulcer disease or a history of aspirin-related gastrointestinal complications (dyspepsia or peptic ulcer) were recruited. The occurrence of ulcer complications (bleeding/perforation/obstruction) was the primary end-point. Results: After a median follow-up of 1 year, nine patients (12%) developed gastrointestinal bleeding and one had a perforated peptic ulcer. Clopidogrel-associated gastrointestinal bleeding was significantly more common in patients with a history of gastrointestinal bleeding than in those without (22% vs. 0%; P = 0.007: odds ratio, 1.3; 95% confidence interval, 1.1-1.5). Conclusions: Clopidogrel is associated with a high incidence of upper gastrointestinal bleeding in high-risk patients. A previous history of gastrointestinal bleeding appears to be a predictor of adverse gastrointestinal events.
Persistent Identifierhttp://hdl.handle.net/10722/77236
ISSN
2013 Impact Factor: 5.478
2013 SCImago Journal Rankings: 2.609
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Ruttonjee Hospital Hong Kong
  3. Hospital Clinico Universitario Lozano Blesa
DC FieldValueLanguage
dc.contributor.authorNg, FHen_HK
dc.contributor.authorWong, SYen_HK
dc.contributor.authorChang, CMen_HK
dc.contributor.authorChen, WHen_HK
dc.contributor.authorKng, Cen_HK
dc.contributor.authorLanas, AIen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-06T07:29:44Z-
dc.date.available2010-09-06T07:29:44Z-
dc.date.issued2003en_HK
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2003, v. 18 n. 4, p. 443-449en_HK
dc.identifier.issn0269-2813en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77236-
dc.description.abstractBackground: In average-risk patients, the new antiplatelet agent, clopidogrel, causes less upper gastrointestinal adverse events than aspirin. However, there are no safety data on the use of clopidogrel in high-risk patients. Aim: To evaluate the safety of clopidogrel in patients with peptic ulcer disease in a retrospective cohort longitudinal study. Methods: During the period from January 2000 to May 2002, 70 patients who were prescribed clopidogrel (75 mg/day) for a previous history of non-aspirin-related peptic ulcer disease or a history of aspirin-related gastrointestinal complications (dyspepsia or peptic ulcer) were recruited. The occurrence of ulcer complications (bleeding/perforation/obstruction) was the primary end-point. Results: After a median follow-up of 1 year, nine patients (12%) developed gastrointestinal bleeding and one had a perforated peptic ulcer. Clopidogrel-associated gastrointestinal bleeding was significantly more common in patients with a history of gastrointestinal bleeding than in those without (22% vs. 0%; P = 0.007: odds ratio, 1.3; 95% confidence interval, 1.1-1.5). Conclusions: Clopidogrel is associated with a high incidence of upper gastrointestinal bleeding in high-risk patients. A previous history of gastrointestinal bleeding appears to be a predictor of adverse gastrointestinal events.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_HK
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_HK
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshAgeden_HK
dc.subject.meshAspirin - adverse effectsen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshGastrointestinal Hemorrhage - chemically induceden_HK
dc.subject.meshHumansen_HK
dc.subject.meshLongitudinal Studiesen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPeptic Ulcer - complications - drug therapyen_HK
dc.subject.meshPlatelet Aggregation Inhibitors - adverse effectsen_HK
dc.subject.meshRecurrenceen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshTiclopidine - adverse effects - analogs & derivativesen_HK
dc.titleHigh incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0269-2813&volume=18&issue=4&spage=443&epage=9&date=2003&atitle=High+Incidence+of+Clopidogrel-Associated+Gastrointestinal+Bleeding+in+Patients+with+Previous+Peptic+Ulcer+Diseaseen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-2036.2003.01693.xen_HK
dc.identifier.pmid12940930en_HK
dc.identifier.scopuseid_2-s2.0-0042830369en_HK
dc.identifier.hkuros86484en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0042830369&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue4en_HK
dc.identifier.spage443en_HK
dc.identifier.epage449en_HK
dc.identifier.isiWOS:000185103200010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridNg, FH=16936078000en_HK
dc.identifier.scopusauthoridWong, SY=7404590845en_HK
dc.identifier.scopusauthoridChang, CM=20833817800en_HK
dc.identifier.scopusauthoridChen, WH=7409637978en_HK
dc.identifier.scopusauthoridKng, C=7801364659en_HK
dc.identifier.scopusauthoridLanas, AI=7006589890en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK

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