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Article: Antralization of gastric incisura is topographically associated with increased gastric epithelial apoptosis and proliferation, but not with CagA seropositivity

TitleAntralization of gastric incisura is topographically associated with increased gastric epithelial apoptosis and proliferation, but not with CagA seropositivity
Authors
Issue Date2004
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal Of Gastroenterology And Hepatology, 2004, v. 19 n. 11, p. 1257-1263 How to Cite?
AbstractBackground and Aims: Helicobacter pylori infection is linked with increased antralization at the gastric incisura. The present study aimed to determine if antralization is associated with altered gastric epithelial apoptosis and proliferation and with seropositivity of the cytotoxin-associated gene product A (CagA) of H. pylori. Methods: Gastric biopsies taken from the antrum, incisura, body and fundus of 75 patients (34 male, 41 female; mean age 59.5 years) were used for diagnosis of H. pylori infection and assessments of histological changes. Apoptosis and Ki-67 expression in epithelial cells were determined for the antral, incisura and body biopsies by immunohistochemistry. Serum samples were tested by enzyme-linked immunosorbent assays for anti-H. pylori and anti-CagA IgG antibodies. Results: Apoptotic index (AI) and Ki-67 proliferation index (PI) were greater in the presence (vs absence) H. pylori infection at the antrum, incisura and body (all P < 0.001), and topographically associated with chronic gastritis and gastric atrophy/intestinal metaplasia at the antrum and incisura (all P < 0.001). Moreover, AI and PI were greater in the presence (vs absence) of antralization at the incisura (20.2 ± 0.9 vs 11.4 ± 0.1.1 and 48.9 ± 2.5 vs 29.9 ± 2.5, both P < 0.001). CagA seroprevalence was 41% in the 39 infected patients. CagA seropositivity was associated with gastric atrophy/intestinal metaplasia at the antrum (χ2 = 4.67,P = 0.03) and incisura (χ2 = 4.88, P = 0.03), but not associated with gastric epithelial apoptosis and Ki-67 expression, nor with antralization at the incisura. Conclusions: Antralization of gastric incisura is topographically associated with increased gastric epithelial apoptosis and proliferation, but not with CagA seropositivity. © 2004 Blackwell Publishing Asia Pty Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/77210
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXia, HHXen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorZhang, GSen_HK
dc.contributor.authorYang, Yen_HK
dc.contributor.authorWyatt, JMen_HK
dc.contributor.authorAdams, Sen_HK
dc.contributor.authorCheung, Ken_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorTalley, NJen_HK
dc.date.accessioned2010-09-06T07:29:27Z-
dc.date.available2010-09-06T07:29:27Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2004, v. 19 n. 11, p. 1257-1263en_HK
dc.identifier.issn0815-9319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77210-
dc.description.abstractBackground and Aims: Helicobacter pylori infection is linked with increased antralization at the gastric incisura. The present study aimed to determine if antralization is associated with altered gastric epithelial apoptosis and proliferation and with seropositivity of the cytotoxin-associated gene product A (CagA) of H. pylori. Methods: Gastric biopsies taken from the antrum, incisura, body and fundus of 75 patients (34 male, 41 female; mean age 59.5 years) were used for diagnosis of H. pylori infection and assessments of histological changes. Apoptosis and Ki-67 expression in epithelial cells were determined for the antral, incisura and body biopsies by immunohistochemistry. Serum samples were tested by enzyme-linked immunosorbent assays for anti-H. pylori and anti-CagA IgG antibodies. Results: Apoptotic index (AI) and Ki-67 proliferation index (PI) were greater in the presence (vs absence) H. pylori infection at the antrum, incisura and body (all P < 0.001), and topographically associated with chronic gastritis and gastric atrophy/intestinal metaplasia at the antrum and incisura (all P < 0.001). Moreover, AI and PI were greater in the presence (vs absence) of antralization at the incisura (20.2 ± 0.9 vs 11.4 ± 0.1.1 and 48.9 ± 2.5 vs 29.9 ± 2.5, both P < 0.001). CagA seroprevalence was 41% in the 39 infected patients. CagA seropositivity was associated with gastric atrophy/intestinal metaplasia at the antrum (χ2 = 4.67,P = 0.03) and incisura (χ2 = 4.88, P = 0.03), but not associated with gastric epithelial apoptosis and Ki-67 expression, nor with antralization at the incisura. Conclusions: Antralization of gastric incisura is topographically associated with increased gastric epithelial apoptosis and proliferation, but not with CagA seropositivity. © 2004 Blackwell Publishing Asia Pty Ltd.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_HK
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAntibodies, Bacterial - blooden_HK
dc.subject.meshAntigens, Bacterial - immunologyen_HK
dc.subject.meshApoptosis - physiologyen_HK
dc.subject.meshBacterial Proteins - immunologyen_HK
dc.subject.meshCell Proliferationen_HK
dc.subject.meshEpithelial Cells - physiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGastrointestinal Diseases - blood - microbiology - pathologyen_HK
dc.subject.meshHelicobacter Infections - complications - pathologyen_HK
dc.subject.meshHelicobacter pylori - immunologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKi-67 Antigen - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshStomach - microbiology - pathologyen_HK
dc.titleAntralization of gastric incisura is topographically associated with increased gastric epithelial apoptosis and proliferation, but not with CagA seropositivityen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0815-9319&volume=19&spage=1257&epage=1263&date=2004&atitle=Antralization+of+Gastric+Incisura+is+Topographically+Associated+with+Increased+Gastric+Epithelial+Apoptosis+and+Proliferation,+but+not+with+CagA+Seropositivityen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1746.2004.03489.xen_HK
dc.identifier.pmid15482532en_HK
dc.identifier.scopuseid_2-s2.0-8344285089en_HK
dc.identifier.hkuros96173en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-8344285089&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1257en_HK
dc.identifier.epage1263en_HK
dc.identifier.isiWOS:000225063000006-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridXia, HHX=8757161400en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridZhang, GS=7405267915en_HK
dc.identifier.scopusauthoridYang, Y=8675011000en_HK
dc.identifier.scopusauthoridWyatt, JM=7202561816en_HK
dc.identifier.scopusauthoridAdams, S=7402058282en_HK
dc.identifier.scopusauthoridCheung, K=7402406545en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridTalley, NJ=36045241200en_HK

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