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Article: Glucose-6-phosphate dehydrogenase deficiency and hematopoietic stem cell transplantation

TitleGlucose-6-phosphate dehydrogenase deficiency and hematopoietic stem cell transplantation
Authors
KeywordsBone marrow transplantation
Clonal
Female
Glucose 6-phosphate dehydrogenase (G6PD) deficiency
Issue Date2002
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
Citation
Bone Marrow Transplantation, 2002, v. 29 n. 5, p. 399-402 How to Cite?
AbstractGlucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked hemolytic enzymopathy affecting 3% of Southern Chinese males. Among 275 adult allogeneic hematopoietic stem cell transplantations (SCT), five cases (1.8%) each of donors and recipients were G6PD deficient. Among 107 autologous SCT, four patients (3.7%) were G6PD deficient. All subjects were male, except for two female patients with chronic myeloid leukemia (CML). The incidence of G6PD deficiency in female CML patients was significantly higher than the background female incidence (P = 0.004), but comparable with that in the males (P = 0.664). There was no significant hemolysis or delay in red cell engraftment, and all but one patient converted to donor G6PD screening status. One female patient achieved partial correction of her G6PD status and relapsed at 10 months. We suggest that G6PD deficiency should be tested for in all marrow donors and recipients in susceptible populations. From our data, there is a suggestion of increased clinical incidence of G6PD deficiency in femal patients with multi-lineage clonal marrow disorders.
Persistent Identifierhttp://hdl.handle.net/10722/77197
ISSN
2015 Impact Factor: 3.636
2015 SCImago Journal Rankings: 1.585
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorCheng, Ten_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:29:19Z-
dc.date.available2010-09-06T07:29:19Z-
dc.date.issued2002en_HK
dc.identifier.citationBone Marrow Transplantation, 2002, v. 29 n. 5, p. 399-402en_HK
dc.identifier.issn0268-3369en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77197-
dc.description.abstractGlucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked hemolytic enzymopathy affecting 3% of Southern Chinese males. Among 275 adult allogeneic hematopoietic stem cell transplantations (SCT), five cases (1.8%) each of donors and recipients were G6PD deficient. Among 107 autologous SCT, four patients (3.7%) were G6PD deficient. All subjects were male, except for two female patients with chronic myeloid leukemia (CML). The incidence of G6PD deficiency in female CML patients was significantly higher than the background female incidence (P = 0.004), but comparable with that in the males (P = 0.664). There was no significant hemolysis or delay in red cell engraftment, and all but one patient converted to donor G6PD screening status. One female patient achieved partial correction of her G6PD status and relapsed at 10 months. We suggest that G6PD deficiency should be tested for in all marrow donors and recipients in susceptible populations. From our data, there is a suggestion of increased clinical incidence of G6PD deficiency in femal patients with multi-lineage clonal marrow disorders.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmten_HK
dc.relation.ispartofBone Marrow Transplantationen_HK
dc.subjectBone marrow transplantationen_HK
dc.subjectClonalen_HK
dc.subjectFemaleen_HK
dc.subjectGlucose 6-phosphate dehydrogenase (G6PD) deficiencyen_HK
dc.titleGlucose-6-phosphate dehydrogenase deficiency and hematopoietic stem cell transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-3369&volume=29&issue=5&spage=399&epage=402&date=2002&atitle=Glucose-6-phosphate+dehydrogenase+deficiency+and+hematopoietic+stem+cell+transplantationen_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.bmt.1703369en_HK
dc.identifier.scopuseid_2-s2.0-0036210665en_HK
dc.identifier.hkuros67877en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036210665&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue5en_HK
dc.identifier.spage399en_HK
dc.identifier.epage402en_HK
dc.identifier.isiWOS:000174611400006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridMa, SK=9042504200en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridCheng, T=7404082613en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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