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Article: Thyroid dysfunction in ambulatory elderly Chinese subjects in an area of borderline iodine intake

TitleThyroid dysfunction in ambulatory elderly Chinese subjects in an area of borderline iodine intake
Authors
Issue Date1996
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/thy
Citation
Thyroid, 1996, v. 6 n. 2, p. 111-114 How to Cite?
AbstractThyroid dysfunction has been reported to occur in 10% of the elderly population in Caucasians. As the nature and prevalence vary tremendously between ethnic groups, and no data are available for Chinese, a primary thyrotropin (TSH) screening program using a supersensitive TSH assay was performed on 1880 ambulatory elderly southern Chinese aged above 60 in Hong Kong, an area of borderline iodine intake. Full thyroid function testing was performed on 600 randomly selected samples with normal TSH values and also on subjects with abnormal TSH levels. The results showed that TSH decreased with age in women (p < 0.05) but not in men. The median values for TSH for women 60-69, 70-79, and >80 years old were 1.40, 1.30, and 1.20, respectively, while for men it was 1.30 mIU/L. Elevated TSH values (>5.0 mIU/L) were found in 19 (1.0%) while suppressed TSH values (<0.1 mIU/L) were present in 28 (1.5%) subjects. Biochemical hypothyroidism and hyperthyroidism were present in 3 and 12 subjects, respectively. Two-thirds of the subjects with abnormal TSH values had antithyroid antibodies. Full assessment of the 600 subjects revealed the prevalence rates for antithyroglobulin and antithyroid peroxidase antibody of 10.2 and 11.2%, respectively. Those who were positive for antithyroid antibodies had significantly higher TSH levels (p < 0.005). Free T4 decreased (p < 0.01) while free T3 increased (p < 0.001) with age in the females resulting in higher free T3/free T4 ratio with aging (p < 0.001). This, however, was not seen in the males. In conclusion, thyroid dysfunction in elderly Chinese occurs predominantly in the female. The cause could be explained by both autoimmune thyroid disease as well as iodine insufficiency.
Persistent Identifierhttp://hdl.handle.net/10722/77181
ISSN
2015 Impact Factor: 3.784
2015 SCImago Journal Rankings: 1.458
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKung, AWCen_HK
dc.contributor.authorJanus, EDen_HK
dc.date.accessioned2010-09-06T07:29:08Z-
dc.date.available2010-09-06T07:29:08Z-
dc.date.issued1996en_HK
dc.identifier.citationThyroid, 1996, v. 6 n. 2, p. 111-114en_HK
dc.identifier.issn1050-7256en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77181-
dc.description.abstractThyroid dysfunction has been reported to occur in 10% of the elderly population in Caucasians. As the nature and prevalence vary tremendously between ethnic groups, and no data are available for Chinese, a primary thyrotropin (TSH) screening program using a supersensitive TSH assay was performed on 1880 ambulatory elderly southern Chinese aged above 60 in Hong Kong, an area of borderline iodine intake. Full thyroid function testing was performed on 600 randomly selected samples with normal TSH values and also on subjects with abnormal TSH levels. The results showed that TSH decreased with age in women (p < 0.05) but not in men. The median values for TSH for women 60-69, 70-79, and >80 years old were 1.40, 1.30, and 1.20, respectively, while for men it was 1.30 mIU/L. Elevated TSH values (>5.0 mIU/L) were found in 19 (1.0%) while suppressed TSH values (<0.1 mIU/L) were present in 28 (1.5%) subjects. Biochemical hypothyroidism and hyperthyroidism were present in 3 and 12 subjects, respectively. Two-thirds of the subjects with abnormal TSH values had antithyroid antibodies. Full assessment of the 600 subjects revealed the prevalence rates for antithyroglobulin and antithyroid peroxidase antibody of 10.2 and 11.2%, respectively. Those who were positive for antithyroid antibodies had significantly higher TSH levels (p < 0.005). Free T4 decreased (p < 0.01) while free T3 increased (p < 0.001) with age in the females resulting in higher free T3/free T4 ratio with aging (p < 0.001). This, however, was not seen in the males. In conclusion, thyroid dysfunction in elderly Chinese occurs predominantly in the female. The cause could be explained by both autoimmune thyroid disease as well as iodine insufficiency.en_HK
dc.languageengen_HK
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/thyen_HK
dc.relation.ispartofThyroiden_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAging - metabolismen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshDieten_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIodide Peroxidase - metabolismen_HK
dc.subject.meshIodine - administration & dosage - urineen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshThyroglobulin - analysisen_HK
dc.subject.meshThyroid Diseases - epidemiologyen_HK
dc.subject.meshThyroid Function Testsen_HK
dc.subject.meshThyrotropin - blooden_HK
dc.subject.meshThyroxine - blooden_HK
dc.subject.meshTriiodothyronine - blooden_HK
dc.titleThyroid dysfunction in ambulatory elderly Chinese subjects in an area of borderline iodine intakeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1050-7256&volume=6&spage=111&epage=114&date=1996&atitle=Thyroid+dysfunction+in+ambulatory+elderly+Chinese+subjects+in+an+area+of+borderline+iodine+intakeen_HK
dc.identifier.emailKung, AWC:awckung@hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8733881-
dc.identifier.scopuseid_2-s2.0-0029937994en_HK
dc.identifier.hkuros10880en_HK
dc.identifier.hkuros25893-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029937994&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue2en_HK
dc.identifier.spage111en_HK
dc.identifier.epage114en_HK
dc.identifier.isiWOS:A1996UJ98900008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK

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