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Article: High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women

TitleHigh dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women
Authors
Issue Date2001
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
Citation
Journal Of Clinical Endocrinology And Metabolism, 2001, v. 86 n. 11, p. 5217-5221 How to Cite?
AbstractAnimal studies demonstrated that phytoestrogen had a protective effect against bone loss after ovariectomy. However, data on dietary phytoestrogen intake as well as its relationship with bone mineral density (BMD) in human are not available. Six hundred fifty southern Chinese women, aged 19 to 86 yr, were recruited to determine their dietary phytoestrogen intake by a food frequency questionnaire. BMDs at the lumbar spine and hip region were measured using dual energy x-ray absorptiometry. The subjects were analyzed according to various tertiles of phytoestrogen intake. Among the postmenopausal women (n = 357), significant differences in the lumbar spine (L2-4) BMD (0.820 ± 0.145 vs. 0.771 ± 0.131 g/cm2,P < 0.05) and Ward's triangle BMD (0.450 ± 0.151 vs. 0.415 ± 0.142 g/cm2; P < 0.05) were found between the highest and lowest intake of isoflavone after adjusting for age, height, weight, years since menopause, smoking, alcohol consumption, HRT usage, and daily calcium intake. Women with the highest intake of isoflavone had significantly lower levels of serum PTH (19.38 ± 14.61 vs. 26.56 ± 11.19 pg/ml; P < 0.05), osteocalcin (4.95 ± 3.61 vs. 6.69 ± 5.05 mg/liter; P = 0.05), and urinary N-telopeptide (34.18 ± 25.31 vs. 49.66 ± 41.00 nmol bone collagen equivalents/mmol creatinine; P < 0.05) when compared with those with the lowest intake of isoflavone. No association between dietary phytoestrogen intake and BMDs was seen in the premenopausal women with high endogenous E (n = 293). In conclusion, postmenopausal women with habitually high intake of dietary isoflavone are associated with higher BMD values at both the spine and hip region. Customarily high isoflavone intake may help to reverse the state of secondary hyperparathyroidism associated with E withdrawal and hence lower the rate of bone turnover in postmenopausal women.
Persistent Identifierhttp://hdl.handle.net/10722/77174
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.940
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMei, Jen_HK
dc.contributor.authorYeung, SSCen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2010-09-06T07:29:04Z-
dc.date.available2010-09-06T07:29:04Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 2001, v. 86 n. 11, p. 5217-5221en_HK
dc.identifier.issn0021-972Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/77174-
dc.description.abstractAnimal studies demonstrated that phytoestrogen had a protective effect against bone loss after ovariectomy. However, data on dietary phytoestrogen intake as well as its relationship with bone mineral density (BMD) in human are not available. Six hundred fifty southern Chinese women, aged 19 to 86 yr, were recruited to determine their dietary phytoestrogen intake by a food frequency questionnaire. BMDs at the lumbar spine and hip region were measured using dual energy x-ray absorptiometry. The subjects were analyzed according to various tertiles of phytoestrogen intake. Among the postmenopausal women (n = 357), significant differences in the lumbar spine (L2-4) BMD (0.820 ± 0.145 vs. 0.771 ± 0.131 g/cm2,P < 0.05) and Ward's triangle BMD (0.450 ± 0.151 vs. 0.415 ± 0.142 g/cm2; P < 0.05) were found between the highest and lowest intake of isoflavone after adjusting for age, height, weight, years since menopause, smoking, alcohol consumption, HRT usage, and daily calcium intake. Women with the highest intake of isoflavone had significantly lower levels of serum PTH (19.38 ± 14.61 vs. 26.56 ± 11.19 pg/ml; P < 0.05), osteocalcin (4.95 ± 3.61 vs. 6.69 ± 5.05 mg/liter; P = 0.05), and urinary N-telopeptide (34.18 ± 25.31 vs. 49.66 ± 41.00 nmol bone collagen equivalents/mmol creatinine; P < 0.05) when compared with those with the lowest intake of isoflavone. No association between dietary phytoestrogen intake and BMDs was seen in the premenopausal women with high endogenous E (n = 293). In conclusion, postmenopausal women with habitually high intake of dietary isoflavone are associated with higher BMD values at both the spine and hip region. Customarily high isoflavone intake may help to reverse the state of secondary hyperparathyroidism associated with E withdrawal and hence lower the rate of bone turnover in postmenopausal women.en_HK
dc.languageengen_HK
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.orgen_HK
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismen_HK
dc.rightsJournal of Clinical Endocrinology and Metabolism. Copyright © The Endocrine Society.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshBone Density - drug effectsen_HK
dc.subject.meshChinaen_HK
dc.subject.meshDieten_HK
dc.subject.meshEstrogens, Non-Steroidal - pharmacologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIsoflavones - administration & dosage - pharmacologyen_HK
dc.subject.meshMenopause - physiologyen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPhytoestrogensen_HK
dc.subject.meshPlant Preparationsen_HK
dc.subject.meshPostmenopause - physiologyen_HK
dc.subject.meshSoybeansen_HK
dc.titleHigh dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal womenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-972X&volume=86&issue=11&spage=5217&epage=5221&date=2001&atitle=High+dietary+phytoestrogen+intake+is+associated+with+higher+bone+mineral+density+in+postmenopausal+but+not+premenopausal+womenen_HK
dc.identifier.emailKung, AWC:awckung@hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1210/jc.86.11.5217en_HK
dc.identifier.pmid11701680-
dc.identifier.scopuseid_2-s2.0-0035181619en_HK
dc.identifier.hkuros66570en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035181619&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume86en_HK
dc.identifier.issue11en_HK
dc.identifier.spage5217en_HK
dc.identifier.epage5221en_HK
dc.identifier.isiWOS:000172137600019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMei, J=36857287900en_HK
dc.identifier.scopusauthoridYeung, SSC=7102767673en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK

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