Article: Positive association between gastro-oesophageal reflux disease and irritable bowel syndrome in a Chinese population

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TitlePositive association between gastro-oesophageal reflux disease and irritable bowel syndrome in a Chinese population
AuthorsCheung, TK1
Lam, KF1
Hu, WHC1
Lam, CLK1
Wong, WM1
Hui, WM1
Lai, KC1
Lam, SK1
Wong, BCY1
Issue Date2007
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
CitationAlimentary Pharmacology And Therapeutics, 2007, v. 25 n. 9, p. 1099-1104 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2036.2007.03304.x
AbstractBackground: Gastro-oesophageal reflux disease and irritable bowel syndrome are common diseases which may be related. Aim: To examine the association between gastro-oesophageal reflux disease and irritable bowel syndrome in Chinese population in Hong Kong. Methods: Randomly selected ethnic Chinese were invited to participate in a telephone survey in 1996. Gastro-oesophageal reflux disease was defined as subjects having heartburn and/or acid regurgitation once weekly or more. Irritable bowel syndrome was diagnosed according to the Rome I criteria. The association between gastro-oesophageal reflux disease and irritable bowel syndrome was calculated using a statistical model which allows the odds ratio to be measured. Results: One thousand six hundred and forty-nine subjects completed the interview (response rate 62%). The population prevalence of gastro-oesophageal reflux disease and irritable bowel syndrome were 5% and 4%, respectively. Thirteen per cent of subjects with gastro-oesophageal reflux disease and 11% with irritable bowel syndrome suffered from both gastro-oesophageal reflux disease and irritable bowel syndrome. The OR of having gastro-oesophageal reflux disease and irritable bowel syndrome together was estimated to be 3 (95% CI: 1.05, 6.27) indicating a positive association between the two diseases. This association occurred predominantly in male subjects [OR = 9.3, (95% CI: 2.3, 26.2)] but not as strong in females [OR = 1.5, (95% CI: 0.3, 4.3)]. Younger subjects were statistically more prone to the two diseases. Conclusions: There is a positive association between gastro-oesophageal reflux disease and irritable bowel syndrome, and their association occurs predominantly in male subjects. © 2007 The Authors.
ISSN0269-2813
2011 Impact Factor: 3.769
2011 SCImago Journal Rankings: 0.338
DOIhttp://dx.doi.org/10.1111/j.1365-2036.2007.03304.x
ISI Accession Number IDWOS:000245602300011
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorCheung, TK
dc.contributor.authorLam, KF
dc.contributor.authorHu, WHC
dc.contributor.authorLam, CLK
dc.contributor.authorWong, WM
dc.contributor.authorHui, WM
dc.contributor.authorLai, KC
dc.contributor.authorLam, SK
dc.contributor.authorWong, BCY
dc.date.accessioned2010-09-06T07:28:48Z
dc.date.available2010-09-06T07:28:48Z
dc.date.issued2007
dc.description.abstractBackground: Gastro-oesophageal reflux disease and irritable bowel syndrome are common diseases which may be related. Aim: To examine the association between gastro-oesophageal reflux disease and irritable bowel syndrome in Chinese population in Hong Kong. Methods: Randomly selected ethnic Chinese were invited to participate in a telephone survey in 1996. Gastro-oesophageal reflux disease was defined as subjects having heartburn and/or acid regurgitation once weekly or more. Irritable bowel syndrome was diagnosed according to the Rome I criteria. The association between gastro-oesophageal reflux disease and irritable bowel syndrome was calculated using a statistical model which allows the odds ratio to be measured. Results: One thousand six hundred and forty-nine subjects completed the interview (response rate 62%). The population prevalence of gastro-oesophageal reflux disease and irritable bowel syndrome were 5% and 4%, respectively. Thirteen per cent of subjects with gastro-oesophageal reflux disease and 11% with irritable bowel syndrome suffered from both gastro-oesophageal reflux disease and irritable bowel syndrome. The OR of having gastro-oesophageal reflux disease and irritable bowel syndrome together was estimated to be 3 (95% CI: 1.05, 6.27) indicating a positive association between the two diseases. This association occurred predominantly in male subjects [OR = 9.3, (95% CI: 2.3, 26.2)] but not as strong in females [OR = 1.5, (95% CI: 0.3, 4.3)]. Younger subjects were statistically more prone to the two diseases. Conclusions: There is a positive association between gastro-oesophageal reflux disease and irritable bowel syndrome, and their association occurs predominantly in male subjects. © 2007 The Authors.
dc.description.naturelink_to_subscribed_fulltext
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2007, v. 25 n. 9, p. 1099-1104 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2036.2007.03304.x
dc.identifier.citeulike1225499
dc.identifier.doihttp://dx.doi.org/10.1111/j.1365-2036.2007.03304.x
dc.identifier.epage1104
dc.identifier.hkuros127505
dc.identifier.hkuros129260
dc.identifier.isiWOS:000245602300011
dc.identifier.issn0269-2813
2011 Impact Factor: 3.769
2011 SCImago Journal Rankings: 0.338
dc.identifier.issue9
dc.identifier.openurl
dc.identifier.pmid17439511
dc.identifier.scopuseid_2-s2.0-34247101532
dc.identifier.spage1099
dc.identifier.urihttp://hdl.handle.net/10722/77149
dc.identifier.volume25
dc.languageeng
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
dc.publisher.placeUnited Kingdom
dc.relation.ispartofAlimentary Pharmacology and Therapeutics
dc.relation.referencesReferences in Scopus
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAge Factors
dc.subject.meshAged
dc.subject.meshAnxiety - complications
dc.subject.meshChina - ethnology
dc.subject.meshDepressive Disorder - complications
dc.subject.meshFemale
dc.subject.meshGastroesophageal Reflux - ethnology - etiology
dc.subject.meshHong Kong - epidemiology
dc.subject.meshHumans
dc.subject.meshIrritable Bowel Syndrome - ethnology - etiology
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPrevalence
dc.subject.meshQuestionnaires
dc.subject.meshSex Factors
dc.subject.meshSick Leave - statistics & numerical data
dc.titlePositive association between gastro-oesophageal reflux disease and irritable bowel syndrome in a Chinese population
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong