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Article: Burden of carotid atherosclerosis in patients with stroke: Relationships with circulating endothelial progenitor cells and hypertension

TitleBurden of carotid atherosclerosis in patients with stroke: Relationships with circulating endothelial progenitor cells and hypertension
Authors
Issue Date2007
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
Citation
Journal Of Human Hypertension, 2007, v. 21 n. 6, p. 445-451 How to Cite?
AbstractRecent studies suggest that reductions in circulating endothelial progenitor cells (EPCs) may contribute to the development of atherosclerosis. However, whether reduced circulating EPCs contribute to cerebrovascular disease remains undefined. We tested the hypothesis that reduced circulating EPCs was associated with an increased burden of carotid atherosclerosis. The level of circulating CD34+/ KDR+ EPCs and the extent of carotid atherosclerosis were determined in 30 patients with a history of atherothrombotic ischaemic stroke and 30 age- and sex-matched controls (mean age: 63 ± 2 years; 63% men). Stroke patients, compared with controls, had significantly higher carotid mean maximum intima-media thickness (mmIMT) (1.08 ± .05 versus 0.90 ± 0.02mm, P = 0.002), prevalence of carotid plaque (60.0 versus 23.3%, P = 0.004) and a lower number of circulating CD34+/KDR+ EPCs (235.7 ± 45.5 versus 400.4 ± 56.8 cells/μl, P = 0.027). The circulating CD34+/KDR+ EPC count correlated negatively with carotid mmIMT (r = -0.50, P < 0.001), and was an independent risk factor for increased carotid mmIMT>1mm (odds ratio (OR): 7.71; 95% confidence interval (CI): 1.62-36.74, P = 0.010) and the presence of carotid plaque (OR: 7.04; 95% CI: 1.95-25.43, P = 0.003). Furthermore, stroke patients with low (<25th percentile of controls) as compared to those with normal CD34+/KDR+ EPC count had a significantly greater carotid mmIMT (1.21 ± 0.07 versus 0.93 ± 0.05 mm, P = 0.005) and a significantly higher prevalence of carotid plaque (87.5% versus 28.6%; P = 0.001). Our observations suggested that reduced circulating EPC may contribute to the progression of carotid atherosclerosis. Circulating EPC count may provide a novel marker for the burden of carotid atherosclerosis.
Persistent Identifierhttp://hdl.handle.net/10722/77143
ISSN
2015 Impact Factor: 2.833
2015 SCImago Journal Rankings: 1.167
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, KKen_HK
dc.contributor.authorChan, YHen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorLi, SWen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-09-06T07:28:44Z-
dc.date.available2010-09-06T07:28:44Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Human Hypertension, 2007, v. 21 n. 6, p. 445-451en_HK
dc.identifier.issn0950-9240en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77143-
dc.description.abstractRecent studies suggest that reductions in circulating endothelial progenitor cells (EPCs) may contribute to the development of atherosclerosis. However, whether reduced circulating EPCs contribute to cerebrovascular disease remains undefined. We tested the hypothesis that reduced circulating EPCs was associated with an increased burden of carotid atherosclerosis. The level of circulating CD34+/ KDR+ EPCs and the extent of carotid atherosclerosis were determined in 30 patients with a history of atherothrombotic ischaemic stroke and 30 age- and sex-matched controls (mean age: 63 ± 2 years; 63% men). Stroke patients, compared with controls, had significantly higher carotid mean maximum intima-media thickness (mmIMT) (1.08 ± .05 versus 0.90 ± 0.02mm, P = 0.002), prevalence of carotid plaque (60.0 versus 23.3%, P = 0.004) and a lower number of circulating CD34+/KDR+ EPCs (235.7 ± 45.5 versus 400.4 ± 56.8 cells/μl, P = 0.027). The circulating CD34+/KDR+ EPC count correlated negatively with carotid mmIMT (r = -0.50, P < 0.001), and was an independent risk factor for increased carotid mmIMT>1mm (odds ratio (OR): 7.71; 95% confidence interval (CI): 1.62-36.74, P = 0.010) and the presence of carotid plaque (OR: 7.04; 95% CI: 1.95-25.43, P = 0.003). Furthermore, stroke patients with low (<25th percentile of controls) as compared to those with normal CD34+/KDR+ EPC count had a significantly greater carotid mmIMT (1.21 ± 0.07 versus 0.93 ± 0.05 mm, P = 0.005) and a significantly higher prevalence of carotid plaque (87.5% versus 28.6%; P = 0.001). Our observations suggested that reduced circulating EPC may contribute to the progression of carotid atherosclerosis. Circulating EPC count may provide a novel marker for the burden of carotid atherosclerosis.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhhen_HK
dc.relation.ispartofJournal of Human Hypertensionen_HK
dc.subject.meshAntigens, CD34 - analysisen_HK
dc.subject.meshArteriosclerosis - etiology - pathology - ultrasonographyen_HK
dc.subject.meshCarotid Arteries - pathology - ultrasonographyen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshCell Counten_HK
dc.subject.meshEndothelial Cells - pathologyen_HK
dc.subject.meshEndothelium, Vascular - pathology - ultrastructureen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshStem Cells - pathologyen_HK
dc.subject.meshStroke - pathologyen_HK
dc.subject.meshTunica Intima - ultrasonographyen_HK
dc.subject.meshTunica Media - ultrasonographyen_HK
dc.titleBurden of carotid atherosclerosis in patients with stroke: Relationships with circulating endothelial progenitor cells and hypertensionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0950-9240&volume=21&issue=6&spage=445&epage=451&date=2007&atitle=Burden+of+carotid+atherosclerosis+in+patients+with+stroke:+relationships+with+circulating+endothelial+progenitor+cells+and+hypertensionen_HK
dc.identifier.emailLau, KK:gkklau@hku.hken_HK
dc.identifier.emailChan, YH:chanwill@hku.hken_HK
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityLau, KK=rp01499en_HK
dc.identifier.authorityChan, YH=rp01313en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.jhh.1002178en_HK
dc.identifier.pmid17361211-
dc.identifier.scopuseid_2-s2.0-34249318066en_HK
dc.identifier.hkuros126516en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34249318066&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue6en_HK
dc.identifier.spage445en_HK
dc.identifier.epage451en_HK
dc.identifier.eissn1476-5527-
dc.identifier.isiWOS:000246799500005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLau, KK=22635159600en_HK
dc.identifier.scopusauthoridChan, YH=22633700600en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridLi, SW=13807028100en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.citeulike1166597-

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