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Article: Comparison of digoxin versus low-dose amiodarone for ventricular rate control in patients with chronic atrial fibrillation

TitleComparison of digoxin versus low-dose amiodarone for ventricular rate control in patients with chronic atrial fibrillation
Authors
Issue Date2001
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 2001, v. 28 n. 5-6, p. 446-450 How to Cite?
Abstract1. Rapid ventricular rate (VR) and rhythm irregularity during atrial fibrillation (AF) impair cardiac performance. Although digoxin has been widely used in patients with AF, its efficacy for the control of VR and rhythm irregularity is unsatisfactory. Whether low-dose amiodarone is more effective remains unclear. 2. We randomized 16 patients (13 male, three female; mean (±SD) age 63 ± 9 years) with chronic AF to receive either digoxin or amiodarone for 24 weeks. At baseline and at 12 and 24 weeks follow up, Holter monitor recording and cardiopulmonary exercise test were performed to assess VR and rhythm irregularity control and exercise capacity. 3. Seven and nine patients received digoxin and amiodarone, respectively. After 12 and 24 weeks treatment, both digoxin and amiodarone significantly decreased the mean ambulatory VR and the VR during peak exercise compared with baseline (all P < 0.05). At 24 weeks, there were no significant differences between digoxin and amiodarone in the percentage reduction in VR during ambulatory (27 ± 13 vs 25 ± 12%, respectively; P = 0.8) and peak exercise (13 ± 12 vs 12 ± 10 % %, respectively; P = 0.6). 4. The rhythm irregularity, as measured by SD of RR intervals and the root mean square of the SD of RR intervals, and the exercise capacity, as measured by exercise workload, maximal oxygen consumption (Vo2), minute ventilation, ventilatory equivalent and oxygen pulse, were not significantly changed after treatment with digoxin or amiodarone (all P > 0.05). 5. Quality of life, determined by SF-36 questionnaire, and AF symptomatology, as measured by the AF Symptom Checklist, were also not significantly changed after treatment with digoxin or amiodarone (all P > 0.05). 6. In conclusion, digoxin and low-dose amiodarone had similar efficacy in the control of VR during ambulatory activity and exercise. However, both were less efficacious during exercise and did not significantly affect rhythm irregularity, exercise capacity, quality of life and AF symptomatology in patients with chronic AF.
Persistent Identifierhttp://hdl.handle.net/10722/77120
ISSN
2012 Impact Factor: 2.16
2015 SCImago Journal Rankings: 0.944
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, HFen_HK
dc.contributor.authorLam, YMen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorKumana, CRen_HK
dc.date.accessioned2010-09-06T07:28:29Z-
dc.date.available2010-09-06T07:28:29Z-
dc.date.issued2001en_HK
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 2001, v. 28 n. 5-6, p. 446-450en_HK
dc.identifier.issn0305-1870en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77120-
dc.description.abstract1. Rapid ventricular rate (VR) and rhythm irregularity during atrial fibrillation (AF) impair cardiac performance. Although digoxin has been widely used in patients with AF, its efficacy for the control of VR and rhythm irregularity is unsatisfactory. Whether low-dose amiodarone is more effective remains unclear. 2. We randomized 16 patients (13 male, three female; mean (±SD) age 63 ± 9 years) with chronic AF to receive either digoxin or amiodarone for 24 weeks. At baseline and at 12 and 24 weeks follow up, Holter monitor recording and cardiopulmonary exercise test were performed to assess VR and rhythm irregularity control and exercise capacity. 3. Seven and nine patients received digoxin and amiodarone, respectively. After 12 and 24 weeks treatment, both digoxin and amiodarone significantly decreased the mean ambulatory VR and the VR during peak exercise compared with baseline (all P < 0.05). At 24 weeks, there were no significant differences between digoxin and amiodarone in the percentage reduction in VR during ambulatory (27 ± 13 vs 25 ± 12%, respectively; P = 0.8) and peak exercise (13 ± 12 vs 12 ± 10 % %, respectively; P = 0.6). 4. The rhythm irregularity, as measured by SD of RR intervals and the root mean square of the SD of RR intervals, and the exercise capacity, as measured by exercise workload, maximal oxygen consumption (Vo2), minute ventilation, ventilatory equivalent and oxygen pulse, were not significantly changed after treatment with digoxin or amiodarone (all P > 0.05). 5. Quality of life, determined by SF-36 questionnaire, and AF symptomatology, as measured by the AF Symptom Checklist, were also not significantly changed after treatment with digoxin or amiodarone (all P > 0.05). 6. In conclusion, digoxin and low-dose amiodarone had similar efficacy in the control of VR during ambulatory activity and exercise. However, both were less efficacious during exercise and did not significantly affect rhythm irregularity, exercise capacity, quality of life and AF symptomatology in patients with chronic AF.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_HK
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAmiodarone - therapeutic useen_HK
dc.subject.meshAnti-Arrhythmia Agents - therapeutic useen_HK
dc.subject.meshAtrial Fibrillation - drug therapy - physiopathologyen_HK
dc.subject.meshDigoxin - therapeutic useen_HK
dc.subject.meshDouble-Blind Methoden_HK
dc.subject.meshEchocardiographyen_HK
dc.subject.meshElectrocardiography, Ambulatoryen_HK
dc.subject.meshExercise Testen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHeart Rate - drug effectsen_HK
dc.subject.meshHeart Ventricles - drug effectsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleComparison of digoxin versus low-dose amiodarone for ventricular rate control in patients with chronic atrial fibrillationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0305-1870&volume=28&issue=5-6&spage=446&epage=450&date=2001&atitle=Comparison+of+digoxin+versus+low-dose+amiodarone+for+ventricular+rate+control+in+patients+with+chronic+atrial+fibrillationen_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1440-1681.2001.03454.xen_HK
dc.identifier.pmid11380520en_HK
dc.identifier.scopuseid_2-s2.0-0034965851en_HK
dc.identifier.hkuros115125en_HK
dc.identifier.hkuros57008-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034965851&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue5-6en_HK
dc.identifier.spage446en_HK
dc.identifier.epage450en_HK
dc.identifier.isiWOS:000168966900015-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridLam, YM=35316083700en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridKumana, CR=7005112381en_HK

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