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Article: Double-blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24-h oesophageal and intragastric pH in Chinese subjects with gastro-oesophageal reflux disease
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TitleDouble-blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24-h oesophageal and intragastric pH in Chinese subjects with gastro-oesophageal reflux disease
 
AuthorsWong, WM1
Lai, KC1
Hui, WM1
Lam, KF1
Huang, JQ1
Hu, WHC1
Wong, NYH1
Lam, CLK1
Xia, HHX1
Chan, AOO1
Lam, SK1
Wong, BCY1
 
Issue Date2004
 
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
 
CitationAlimentary Pharmacology And Therapeutics, 2004, v. 19 n. 4, p. 455-462 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2036.2004.01846.x
 
AbstractBackground: Previous studies have suggested that the acid secretory capacity of the Chinese population is lower than that of the Western population. Aim: To compare the effect of lansoprazole 30 mg and 15 mg once daily on the 24-h oesophageal and intragastric pH profiles in Chinese patients with gastro-oesophageal reflux disease. Methods: Forty-four patients (male to female ratio, 27:17; mean age, 53 years; 55% with oesophagitis) with gastro-oesophageal reflux disease were randomized to receive lansoprazole 30 mg or 15 mg once daily for 4 weeks. Measurement of the 24-h oesophageal and intragastric pH, gastro-oesophageal reflux disease symptoms and quality of life was performed at baseline and during the last week of each dosing period. Results: Lansoprazole 30 mg maintained an intragastric pH > 4 for 10.5 h vs. 9.6 h for lansoprazole 15 mg (P = 0.44). The percentage total time at oesophageal pH < 4 was similar for lansoprazole 30 mg and 15 mg (2.0% vs. 2.3%, P = 0.30). The proportion of patients with complete cure of heartburn and acid regurgitation and the quality of life assessment were similar for lansoprazole 30 mg and 15 mg. Both dosages of lansoprazole were well tolerated and the compliance was 100% in both groups. Conclusion: Lansoprazole dosages of 30 mg and 15 mg once daily provide a satisfactory decrease for oesophageal acid exposure and are equally effective for the treatment of gastro-oesophageal reflux disease in the Chinese population.
 
ISSN0269-2813
2012 Impact Factor: 4.548
2012 SCImago Journal Rankings: 1.689
 
DOIhttp://dx.doi.org/10.1046/j.1365-2036.2004.01846.x
 
ISI Accession Number IDWOS:000188892300010
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWong, WM
 
dc.contributor.authorLai, KC
 
dc.contributor.authorHui, WM
 
dc.contributor.authorLam, KF
 
dc.contributor.authorHuang, JQ
 
dc.contributor.authorHu, WHC
 
dc.contributor.authorWong, NYH
 
dc.contributor.authorLam, CLK
 
dc.contributor.authorXia, HHX
 
dc.contributor.authorChan, AOO
 
dc.contributor.authorLam, SK
 
dc.contributor.authorWong, BCY
 
dc.date.accessioned2010-09-06T07:28:02Z
 
dc.date.available2010-09-06T07:28:02Z
 
dc.date.issued2004
 
dc.description.abstractBackground: Previous studies have suggested that the acid secretory capacity of the Chinese population is lower than that of the Western population. Aim: To compare the effect of lansoprazole 30 mg and 15 mg once daily on the 24-h oesophageal and intragastric pH profiles in Chinese patients with gastro-oesophageal reflux disease. Methods: Forty-four patients (male to female ratio, 27:17; mean age, 53 years; 55% with oesophagitis) with gastro-oesophageal reflux disease were randomized to receive lansoprazole 30 mg or 15 mg once daily for 4 weeks. Measurement of the 24-h oesophageal and intragastric pH, gastro-oesophageal reflux disease symptoms and quality of life was performed at baseline and during the last week of each dosing period. Results: Lansoprazole 30 mg maintained an intragastric pH > 4 for 10.5 h vs. 9.6 h for lansoprazole 15 mg (P = 0.44). The percentage total time at oesophageal pH < 4 was similar for lansoprazole 30 mg and 15 mg (2.0% vs. 2.3%, P = 0.30). The proportion of patients with complete cure of heartburn and acid regurgitation and the quality of life assessment were similar for lansoprazole 30 mg and 15 mg. Both dosages of lansoprazole were well tolerated and the compliance was 100% in both groups. Conclusion: Lansoprazole dosages of 30 mg and 15 mg once daily provide a satisfactory decrease for oesophageal acid exposure and are equally effective for the treatment of gastro-oesophageal reflux disease in the Chinese population.
 
dc.description.natureLink_to_OA_fulltext
 
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2004, v. 19 n. 4, p. 455-462 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2036.2004.01846.x
 
dc.identifier.doihttp://dx.doi.org/10.1046/j.1365-2036.2004.01846.x
 
dc.identifier.epage462
 
dc.identifier.hkuros86283
 
dc.identifier.isiWOS:000188892300010
 
dc.identifier.issn0269-2813
2012 Impact Factor: 4.548
2012 SCImago Journal Rankings: 1.689
 
dc.identifier.issue4
 
dc.identifier.openurl
 
dc.identifier.pmid14871286
 
dc.identifier.scopuseid_2-s2.0-10744232346
 
dc.identifier.spage455
 
dc.identifier.urihttp://hdl.handle.net/10722/77079
 
dc.identifier.volume19
 
dc.languageeng
 
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofAlimentary Pharmacology and Therapeutics
 
dc.relation.referencesReferences in Scopus
 
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.
 
dc.subject.mesh2-Pyridinylmethylsulfinylbenzimidazoles
 
dc.subject.meshAnti-Ulcer Agents - administration & dosage
 
dc.subject.meshChina - ethnology
 
dc.subject.meshCross-Over Studies
 
dc.subject.meshDouble-Blind Method
 
dc.subject.meshFemale
 
dc.subject.meshGastric Acidity Determination
 
dc.subject.meshGastroesophageal Reflux - drug therapy - ethnology
 
dc.subject.meshHumans
 
dc.subject.meshHydrogen-Ion Concentration
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshOmeprazole - administration & dosage - analogs & derivatives
 
dc.subject.meshTreatment Outcome
 
dc.titleDouble-blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24-h oesophageal and intragastric pH in Chinese subjects with gastro-oesophageal reflux disease
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong