Article: Double-blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24-h oesophageal and intragastric pH in Chinese subjects with gastro-oesophageal reflux disease

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TitleDouble-blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24-h oesophageal and intragastric pH in Chinese subjects with gastro-oesophageal reflux disease
AuthorsWong, WM1
Lai, KC1
Hui, WM1
Lam, KF1
Huang, JQ1
Hu, WHC1
Wong, NYH1
Lam, CLK1
Xia, HHX1
Chan, AOO1
Lam, SK1
Wong, BCY1
Issue Date2004
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
CitationAlimentary Pharmacology And Therapeutics, 2004, v. 19 n. 4, p. 455-462 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2036.2004.01846.x
AbstractBackground: Previous studies have suggested that the acid secretory capacity of the Chinese population is lower than that of the Western population. Aim: To compare the effect of lansoprazole 30 mg and 15 mg once daily on the 24-h oesophageal and intragastric pH profiles in Chinese patients with gastro-oesophageal reflux disease. Methods: Forty-four patients (male to female ratio, 27:17; mean age, 53 years; 55% with oesophagitis) with gastro-oesophageal reflux disease were randomized to receive lansoprazole 30 mg or 15 mg once daily for 4 weeks. Measurement of the 24-h oesophageal and intragastric pH, gastro-oesophageal reflux disease symptoms and quality of life was performed at baseline and during the last week of each dosing period. Results: Lansoprazole 30 mg maintained an intragastric pH > 4 for 10.5 h vs. 9.6 h for lansoprazole 15 mg (P = 0.44). The percentage total time at oesophageal pH < 4 was similar for lansoprazole 30 mg and 15 mg (2.0% vs. 2.3%, P = 0.30). The proportion of patients with complete cure of heartburn and acid regurgitation and the quality of life assessment were similar for lansoprazole 30 mg and 15 mg. Both dosages of lansoprazole were well tolerated and the compliance was 100% in both groups. Conclusion: Lansoprazole dosages of 30 mg and 15 mg once daily provide a satisfactory decrease for oesophageal acid exposure and are equally effective for the treatment of gastro-oesophageal reflux disease in the Chinese population.
ISSN0269-2813
2011 Impact Factor: 3.769
2011 SCImago Journal Rankings: 0.338
DOIhttp://dx.doi.org/10.1046/j.1365-2036.2004.01846.x
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorWong, WM
dc.contributor.authorLai, KC
dc.contributor.authorHui, WM
dc.contributor.authorLam, KF
dc.contributor.authorHuang, JQ
dc.contributor.authorHu, WHC
dc.contributor.authorWong, NYH
dc.contributor.authorLam, CLK
dc.contributor.authorXia, HHX
dc.contributor.authorChan, AOO
dc.contributor.authorLam, SK
dc.contributor.authorWong, BCY
dc.date.accessioned2010-09-06T07:28:02Z
dc.date.available2010-09-06T07:28:02Z
dc.date.issued2004
dc.description.abstractBackground: Previous studies have suggested that the acid secretory capacity of the Chinese population is lower than that of the Western population. Aim: To compare the effect of lansoprazole 30 mg and 15 mg once daily on the 24-h oesophageal and intragastric pH profiles in Chinese patients with gastro-oesophageal reflux disease. Methods: Forty-four patients (male to female ratio, 27:17; mean age, 53 years; 55% with oesophagitis) with gastro-oesophageal reflux disease were randomized to receive lansoprazole 30 mg or 15 mg once daily for 4 weeks. Measurement of the 24-h oesophageal and intragastric pH, gastro-oesophageal reflux disease symptoms and quality of life was performed at baseline and during the last week of each dosing period. Results: Lansoprazole 30 mg maintained an intragastric pH > 4 for 10.5 h vs. 9.6 h for lansoprazole 15 mg (P = 0.44). The percentage total time at oesophageal pH < 4 was similar for lansoprazole 30 mg and 15 mg (2.0% vs. 2.3%, P = 0.30). The proportion of patients with complete cure of heartburn and acid regurgitation and the quality of life assessment were similar for lansoprazole 30 mg and 15 mg. Both dosages of lansoprazole were well tolerated and the compliance was 100% in both groups. Conclusion: Lansoprazole dosages of 30 mg and 15 mg once daily provide a satisfactory decrease for oesophageal acid exposure and are equally effective for the treatment of gastro-oesophageal reflux disease in the Chinese population.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2004, v. 19 n. 4, p. 455-462 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2036.2004.01846.x
dc.identifier.doihttp://dx.doi.org/10.1046/j.1365-2036.2004.01846.x
dc.identifier.epage462
dc.identifier.hkuros86283
dc.identifier.isiWOS:000188892300010
dc.identifier.issn0269-2813
2011 Impact Factor: 3.769
2011 SCImago Journal Rankings: 0.338
dc.identifier.issue4
dc.identifier.openurl
dc.identifier.pmid14871286
dc.identifier.scopuseid_2-s2.0-10744232346
dc.identifier.spage455
dc.identifier.urihttp://hdl.handle.net/10722/77079
dc.identifier.volume19
dc.languageeng
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
dc.publisher.placeUnited Kingdom
dc.relation.ispartofAlimentary Pharmacology and Therapeutics
dc.relation.referencesReferences in Scopus
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.
dc.subject.mesh2-Pyridinylmethylsulfinylbenzimidazoles
dc.subject.meshAnti-Ulcer Agents - administration & dosage
dc.subject.meshChina - ethnology
dc.subject.meshCross-Over Studies
dc.subject.meshDouble-Blind Method
dc.subject.meshFemale
dc.subject.meshGastric Acidity Determination
dc.subject.meshGastroesophageal Reflux - drug therapy - ethnology
dc.subject.meshHumans
dc.subject.meshHydrogen-Ion Concentration
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshOmeprazole - administration & dosage - analogs & derivatives
dc.subject.meshTreatment Outcome
dc.titleDouble-blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24-h oesophageal and intragastric pH in Chinese subjects with gastro-oesophageal reflux disease
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong