Article: Asian multicenter trials on urinary type IV collagen in patients with diabetic nephropathy

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TitleAsian multicenter trials on urinary type IV collagen in patients with diabetic nephropathy
AuthorsTomino, Y3 5
Suzuki, S6
Azushima, C2
Shou, I1
Iijima, T4
Yagame, M3
Wang, LN5
Chen, HC6
Lai, KN2
Tan, SY1
Kim, MJ4
KeywordsAsian multicenter trials
Diabetic nephropathy
Urinary type IV collagen
Issue Date2001
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/36921
CitationJournal Of Clinical Laboratory Analysis, 2001, v. 15 n. 4, p. 188-192 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jcla.1026
AbstractTo investigate the changes of renal type IV collagen turnover in diabetic nephropathy, urinary type IV collagen was measured by a highly sensitive one-step sandwich enzyme immunoassay (EIA). Urinary samples were obtained from 698 diabetic patients and 191 healthy adults. Among the patients, 264 had urinary albumin levels of less than 29 mg/g·creatine (Cr) (Stage I: normoalbuminuric stage), 169 had microalbuminuria from 30 to 299 mg/g·Cr (Stage II: microalbuminuric stage), 84 patients had macro-albuminuria of more than 300 mg/g·Cr and serum Cr of less than 1.1 mg/dl (Stage IIIA: macroalbuminuric stage without renal dysfunction), 97 had macroalbuminuria of more than 300 mg/g·Cr and serum Cr of more than 1.2 mg/dl (Stage IIIB: macroalbuminuric stage with renal dysfunction), and 84 had renal failure (Stage IV). The levels of urinary type IV collagen in Stages II, IIIA, IIIB, and IV were significantly higher than those in Stage I (P < 0.0001). The level of urinary type IV collagen in Stage I (5.00 ± 0.23 μg/g·Cr; mean ± SE) was also higher than that in normal adults (3.44 ± 0.11 μg/ g·Cr; mean ± SE). These levels increased gradually due to progression of the clinical stage of diabetic nephropathy. It appears that the levels of urinary type IV collagen can be a useful marker for detecting renal injuries in diabetes according to our Asian multicenter trials. © 2001 Wiley-Liss, Inc.
ISSN0887-8013
2011 Impact Factor: 1.384
2011 SCImago Journal Rankings: 0.103
DOIhttp://dx.doi.org/10.1002/jcla.1026
ISI Accession Number IDWOS:000169717600007
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTomino, Y
dc.contributor.authorSuzuki, S
dc.contributor.authorAzushima, C
dc.contributor.authorShou, I
dc.contributor.authorIijima, T
dc.contributor.authorYagame, M
dc.contributor.authorWang, LN
dc.contributor.authorChen, HC
dc.contributor.authorLai, KN
dc.contributor.authorTan, SY
dc.contributor.authorKim, MJ
dc.date.accessioned2010-09-06T07:28:01Z
dc.date.available2010-09-06T07:28:01Z
dc.date.issued2001
dc.description.abstractTo investigate the changes of renal type IV collagen turnover in diabetic nephropathy, urinary type IV collagen was measured by a highly sensitive one-step sandwich enzyme immunoassay (EIA). Urinary samples were obtained from 698 diabetic patients and 191 healthy adults. Among the patients, 264 had urinary albumin levels of less than 29 mg/g·creatine (Cr) (Stage I: normoalbuminuric stage), 169 had microalbuminuria from 30 to 299 mg/g·Cr (Stage II: microalbuminuric stage), 84 patients had macro-albuminuria of more than 300 mg/g·Cr and serum Cr of less than 1.1 mg/dl (Stage IIIA: macroalbuminuric stage without renal dysfunction), 97 had macroalbuminuria of more than 300 mg/g·Cr and serum Cr of more than 1.2 mg/dl (Stage IIIB: macroalbuminuric stage with renal dysfunction), and 84 had renal failure (Stage IV). The levels of urinary type IV collagen in Stages II, IIIA, IIIB, and IV were significantly higher than those in Stage I (P < 0.0001). The level of urinary type IV collagen in Stage I (5.00 ± 0.23 μg/g·Cr; mean ± SE) was also higher than that in normal adults (3.44 ± 0.11 μg/ g·Cr; mean ± SE). These levels increased gradually due to progression of the clinical stage of diabetic nephropathy. It appears that the levels of urinary type IV collagen can be a useful marker for detecting renal injuries in diabetes according to our Asian multicenter trials. © 2001 Wiley-Liss, Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Clinical Laboratory Analysis, 2001, v. 15 n. 4, p. 188-192 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jcla.1026
dc.identifier.doihttp://dx.doi.org/10.1002/jcla.1026
dc.identifier.epage192
dc.identifier.hkuros69576
dc.identifier.isiWOS:000169717600007
dc.identifier.issn0887-8013
2011 Impact Factor: 1.384
2011 SCImago Journal Rankings: 0.103
dc.identifier.issue4
dc.identifier.openurl
dc.identifier.pmid11436201
dc.identifier.scopuseid_2-s2.0-0034939239
dc.identifier.spage188
dc.identifier.urihttp://hdl.handle.net/10722/77078
dc.identifier.volume15
dc.languageeng
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/36921
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Clinical Laboratory Analysis
dc.relation.referencesReferences in Scopus
dc.rightsJournal of Clinical Laboratory Analysis. Copyright © John Wiley & Sons, Inc.
dc.subjectAsian multicenter trials
dc.subjectDiabetic nephropathy
dc.subjectUrinary type IV collagen
dc.titleAsian multicenter trials on urinary type IV collagen in patients with diabetic nephropathy
dc.typeArticle
Author Affiliations
  1. China Medical University
  2. School of Medicine
  3. The University of Hong Kong
  4. Kaohsiung Medical University
  5. Juntendo University
  6. Juntendo University Urayasu Hospital