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Article: Asian multicenter trials on urinary type IV collagen in patients with diabetic nephropathy
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TitleAsian multicenter trials on urinary type IV collagen in patients with diabetic nephropathy
 
AuthorsTomino, Y5 3
Suzuki, S6
Azushima, C1
Shou, I2
Iijima, T4
Yagame, M3
Wang, LN5
Chen, HC6
Lai, KN1
Tan, SY2
Kim, MJ4
 
KeywordsAsian multicenter trials
Diabetic nephropathy
Urinary type IV collagen
 
Issue Date2001
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/36921
 
CitationJournal Of Clinical Laboratory Analysis, 2001, v. 15 n. 4, p. 188-192 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jcla.1026
 
AbstractTo investigate the changes of renal type IV collagen turnover in diabetic nephropathy, urinary type IV collagen was measured by a highly sensitive one-step sandwich enzyme immunoassay (EIA). Urinary samples were obtained from 698 diabetic patients and 191 healthy adults. Among the patients, 264 had urinary albumin levels of less than 29 mg/g·creatine (Cr) (Stage I: normoalbuminuric stage), 169 had microalbuminuria from 30 to 299 mg/g·Cr (Stage II: microalbuminuric stage), 84 patients had macro-albuminuria of more than 300 mg/g·Cr and serum Cr of less than 1.1 mg/dl (Stage IIIA: macroalbuminuric stage without renal dysfunction), 97 had macroalbuminuria of more than 300 mg/g·Cr and serum Cr of more than 1.2 mg/dl (Stage IIIB: macroalbuminuric stage with renal dysfunction), and 84 had renal failure (Stage IV). The levels of urinary type IV collagen in Stages II, IIIA, IIIB, and IV were significantly higher than those in Stage I (P < 0.0001). The level of urinary type IV collagen in Stage I (5.00 ± 0.23 μg/g·Cr; mean ± SE) was also higher than that in normal adults (3.44 ± 0.11 μg/ g·Cr; mean ± SE). These levels increased gradually due to progression of the clinical stage of diabetic nephropathy. It appears that the levels of urinary type IV collagen can be a useful marker for detecting renal injuries in diabetes according to our Asian multicenter trials. © 2001 Wiley-Liss, Inc.
 
ISSN0887-8013
2013 Impact Factor: 1.144
 
DOIhttp://dx.doi.org/10.1002/jcla.1026
 
ISI Accession Number IDWOS:000169717600007
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTomino, Y
 
dc.contributor.authorSuzuki, S
 
dc.contributor.authorAzushima, C
 
dc.contributor.authorShou, I
 
dc.contributor.authorIijima, T
 
dc.contributor.authorYagame, M
 
dc.contributor.authorWang, LN
 
dc.contributor.authorChen, HC
 
dc.contributor.authorLai, KN
 
dc.contributor.authorTan, SY
 
dc.contributor.authorKim, MJ
 
dc.date.accessioned2010-09-06T07:28:01Z
 
dc.date.available2010-09-06T07:28:01Z
 
dc.date.issued2001
 
dc.description.abstractTo investigate the changes of renal type IV collagen turnover in diabetic nephropathy, urinary type IV collagen was measured by a highly sensitive one-step sandwich enzyme immunoassay (EIA). Urinary samples were obtained from 698 diabetic patients and 191 healthy adults. Among the patients, 264 had urinary albumin levels of less than 29 mg/g·creatine (Cr) (Stage I: normoalbuminuric stage), 169 had microalbuminuria from 30 to 299 mg/g·Cr (Stage II: microalbuminuric stage), 84 patients had macro-albuminuria of more than 300 mg/g·Cr and serum Cr of less than 1.1 mg/dl (Stage IIIA: macroalbuminuric stage without renal dysfunction), 97 had macroalbuminuria of more than 300 mg/g·Cr and serum Cr of more than 1.2 mg/dl (Stage IIIB: macroalbuminuric stage with renal dysfunction), and 84 had renal failure (Stage IV). The levels of urinary type IV collagen in Stages II, IIIA, IIIB, and IV were significantly higher than those in Stage I (P < 0.0001). The level of urinary type IV collagen in Stage I (5.00 ± 0.23 μg/g·Cr; mean ± SE) was also higher than that in normal adults (3.44 ± 0.11 μg/ g·Cr; mean ± SE). These levels increased gradually due to progression of the clinical stage of diabetic nephropathy. It appears that the levels of urinary type IV collagen can be a useful marker for detecting renal injuries in diabetes according to our Asian multicenter trials. © 2001 Wiley-Liss, Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Clinical Laboratory Analysis, 2001, v. 15 n. 4, p. 188-192 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jcla.1026
 
dc.identifier.doihttp://dx.doi.org/10.1002/jcla.1026
 
dc.identifier.epage192
 
dc.identifier.hkuros69576
 
dc.identifier.isiWOS:000169717600007
 
dc.identifier.issn0887-8013
2013 Impact Factor: 1.144
 
dc.identifier.issue4
 
dc.identifier.openurl
 
dc.identifier.pmid11436201
 
dc.identifier.scopuseid_2-s2.0-0034939239
 
dc.identifier.spage188
 
dc.identifier.urihttp://hdl.handle.net/10722/77078
 
dc.identifier.volume15
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/36921
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Clinical Laboratory Analysis
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Clinical Laboratory Analysis. Copyright © John Wiley & Sons, Inc.
 
dc.subjectAsian multicenter trials
 
dc.subjectDiabetic nephropathy
 
dc.subjectUrinary type IV collagen
 
dc.titleAsian multicenter trials on urinary type IV collagen in patients with diabetic nephropathy
 
dc.typeArticle
 
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Author Affiliations
  1. School of Medicine
  2. China Medical University Shenyang
  3. The University of Hong Kong
  4. Kaohsiung Medical University
  5. Juntendo University
  6. Juntendo University Urayasu Hospital