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Article: Asian multicenter trials on urinary type IV collagen in patients with diabetic nephropathy

TitleAsian multicenter trials on urinary type IV collagen in patients with diabetic nephropathy
Authors
KeywordsAsian multicenter trials
Diabetic nephropathy
Urinary type IV collagen
Issue Date2001
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/36921
Citation
Journal Of Clinical Laboratory Analysis, 2001, v. 15 n. 4, p. 188-192 How to Cite?
Abstract
To investigate the changes of renal type IV collagen turnover in diabetic nephropathy, urinary type IV collagen was measured by a highly sensitive one-step sandwich enzyme immunoassay (EIA). Urinary samples were obtained from 698 diabetic patients and 191 healthy adults. Among the patients, 264 had urinary albumin levels of less than 29 mg/g·creatine (Cr) (Stage I: normoalbuminuric stage), 169 had microalbuminuria from 30 to 299 mg/g·Cr (Stage II: microalbuminuric stage), 84 patients had macro-albuminuria of more than 300 mg/g·Cr and serum Cr of less than 1.1 mg/dl (Stage IIIA: macroalbuminuric stage without renal dysfunction), 97 had macroalbuminuria of more than 300 mg/g·Cr and serum Cr of more than 1.2 mg/dl (Stage IIIB: macroalbuminuric stage with renal dysfunction), and 84 had renal failure (Stage IV). The levels of urinary type IV collagen in Stages II, IIIA, IIIB, and IV were significantly higher than those in Stage I (P < 0.0001). The level of urinary type IV collagen in Stage I (5.00 ± 0.23 μg/g·Cr; mean ± SE) was also higher than that in normal adults (3.44 ± 0.11 μg/ g·Cr; mean ± SE). These levels increased gradually due to progression of the clinical stage of diabetic nephropathy. It appears that the levels of urinary type IV collagen can be a useful marker for detecting renal injuries in diabetes according to our Asian multicenter trials. © 2001 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/77078
ISSN
2013 Impact Factor: 1.144
ISI Accession Number ID
References

 

Author Affiliations
  1. School of Medicine
  2. China Medical University Shenyang
  3. The University of Hong Kong
  4. Kaohsiung Medical University
  5. Juntendo University
  6. Juntendo University Urayasu Hospital
DC FieldValueLanguage
dc.contributor.authorTomino, Yen_HK
dc.contributor.authorSuzuki, Sen_HK
dc.contributor.authorAzushima, Cen_HK
dc.contributor.authorShou, Ien_HK
dc.contributor.authorIijima, Ten_HK
dc.contributor.authorYagame, Men_HK
dc.contributor.authorWang, LNen_HK
dc.contributor.authorChen, HCen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorTan, SYen_HK
dc.contributor.authorKim, MJen_HK
dc.date.accessioned2010-09-06T07:28:01Z-
dc.date.available2010-09-06T07:28:01Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Clinical Laboratory Analysis, 2001, v. 15 n. 4, p. 188-192en_HK
dc.identifier.issn0887-8013en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77078-
dc.description.abstractTo investigate the changes of renal type IV collagen turnover in diabetic nephropathy, urinary type IV collagen was measured by a highly sensitive one-step sandwich enzyme immunoassay (EIA). Urinary samples were obtained from 698 diabetic patients and 191 healthy adults. Among the patients, 264 had urinary albumin levels of less than 29 mg/g·creatine (Cr) (Stage I: normoalbuminuric stage), 169 had microalbuminuria from 30 to 299 mg/g·Cr (Stage II: microalbuminuric stage), 84 patients had macro-albuminuria of more than 300 mg/g·Cr and serum Cr of less than 1.1 mg/dl (Stage IIIA: macroalbuminuric stage without renal dysfunction), 97 had macroalbuminuria of more than 300 mg/g·Cr and serum Cr of more than 1.2 mg/dl (Stage IIIB: macroalbuminuric stage with renal dysfunction), and 84 had renal failure (Stage IV). The levels of urinary type IV collagen in Stages II, IIIA, IIIB, and IV were significantly higher than those in Stage I (P < 0.0001). The level of urinary type IV collagen in Stage I (5.00 ± 0.23 μg/g·Cr; mean ± SE) was also higher than that in normal adults (3.44 ± 0.11 μg/ g·Cr; mean ± SE). These levels increased gradually due to progression of the clinical stage of diabetic nephropathy. It appears that the levels of urinary type IV collagen can be a useful marker for detecting renal injuries in diabetes according to our Asian multicenter trials. © 2001 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/36921en_HK
dc.relation.ispartofJournal of Clinical Laboratory Analysisen_HK
dc.rightsJournal of Clinical Laboratory Analysis. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectAsian multicenter trialsen_HK
dc.subjectDiabetic nephropathyen_HK
dc.subjectUrinary type IV collagenen_HK
dc.titleAsian multicenter trials on urinary type IV collagen in patients with diabetic nephropathyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0887-8013&volume=15&spage=188&epage=192&date=2001&atitle=Asian+multicenter+trials+on+urinary+type+IV+collagen+in+patients+with+diabetic+nephropathyen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jcla.1026en_HK
dc.identifier.pmid11436201en_HK
dc.identifier.scopuseid_2-s2.0-0034939239en_HK
dc.identifier.hkuros69576en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034939239&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue4en_HK
dc.identifier.spage188en_HK
dc.identifier.epage192en_HK
dc.identifier.isiWOS:000169717600007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTomino, Y=35352121900en_HK
dc.identifier.scopusauthoridSuzuki, S=7405348898en_HK
dc.identifier.scopusauthoridAzushima, C=19641097400en_HK
dc.identifier.scopusauthoridShou, I=6602107414en_HK
dc.identifier.scopusauthoridIijima, T=16740064700en_HK
dc.identifier.scopusauthoridYagame, M=7004626854en_HK
dc.identifier.scopusauthoridWang, LN=36106515700en_HK
dc.identifier.scopusauthoridChen, HC=16229243500en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridTan, SY=22235263900en_HK
dc.identifier.scopusauthoridKim, MJ=36064811500en_HK

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