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Article: Transformation of diffuse large B-cell lymphoma into pre-B acute lymphoblastic leukemia: Clinicopathologic features and clonal relationship

TitleTransformation of diffuse large B-cell lymphoma into pre-B acute lymphoblastic leukemia: Clinicopathologic features and clonal relationship
Authors
Keywordsacute lymphoblastic leukemia
ALL
clonal evolution
diffuse large B-cell lymphoma
DLBC
EBER
Epstein-Barr virus-expressed RNA
IgH
immunoglobulin heavy chain
PCR
polymerase chain reaction
Tdt
Issue Date2004
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 2004, v. 35 n. 7, p. 900-903 How to Cite?
AbstractA patient with fibrosing alveolitis developed a diffuse large B-cell (DLBC) lymphoma that expressed CD20 and CD30. After an initial response, the lymphoma relapsed and was salvaged with further chemotherapy. After another remission of 3 years, a pre-B-cell acute lymphoblastic leukemia (ALL), which expressed CD10, CD19, CD22, CD79a, CD34 and terminal deoxyribonucleotidyl transferase, developed and led to death. Molecular analysis of the immunoglobulin heavy-chain gene showed that the initial lymphoma and its relapse were clonally related. At leukemic relapse, 2 clones related to the initial and relapsed lymphoma clones were present. DLBC lymphomas arise from post-follicle center B cells, whereas ALL arises from pregerminal B cells. Therefore, a direct transformation of DLBC lymphoma to ALL appears unlikely. The overall features suggest instead separate lymphoma and leukemic evolution from a common mutated B-cell precursor rather than transformation of DLBC lymphoma to ALL. © 2004 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/77072
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorWong, KYen_HK
dc.contributor.authorChung, LPen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorWan, TSen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:27:58Z-
dc.date.available2010-09-06T07:27:58Z-
dc.date.issued2004en_HK
dc.identifier.citationHuman Pathology, 2004, v. 35 n. 7, p. 900-903en_HK
dc.identifier.issn0046-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77072-
dc.description.abstractA patient with fibrosing alveolitis developed a diffuse large B-cell (DLBC) lymphoma that expressed CD20 and CD30. After an initial response, the lymphoma relapsed and was salvaged with further chemotherapy. After another remission of 3 years, a pre-B-cell acute lymphoblastic leukemia (ALL), which expressed CD10, CD19, CD22, CD79a, CD34 and terminal deoxyribonucleotidyl transferase, developed and led to death. Molecular analysis of the immunoglobulin heavy-chain gene showed that the initial lymphoma and its relapse were clonally related. At leukemic relapse, 2 clones related to the initial and relapsed lymphoma clones were present. DLBC lymphomas arise from post-follicle center B cells, whereas ALL arises from pregerminal B cells. Therefore, a direct transformation of DLBC lymphoma to ALL appears unlikely. The overall features suggest instead separate lymphoma and leukemic evolution from a common mutated B-cell precursor rather than transformation of DLBC lymphoma to ALL. © 2004 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_HK
dc.relation.ispartofHuman Pathologyen_HK
dc.subjectacute lymphoblastic leukemiaen_HK
dc.subjectALLen_HK
dc.subjectclonal evolutionen_HK
dc.subjectdiffuse large B-cell lymphomaen_HK
dc.subjectDLBCen_HK
dc.subjectEBERen_HK
dc.subjectEpstein-Barr virus-expressed RNAen_HK
dc.subjectIgHen_HK
dc.subjectimmunoglobulin heavy chainen_HK
dc.subjectPCRen_HK
dc.subjectpolymerase chain reactionen_HK
dc.subjectTdten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - therapeutic useen_HK
dc.subject.meshBase Sequenceen_HK
dc.subject.meshBurkitt Lymphoma - drug therapy - genetics - pathologyen_HK
dc.subject.meshCell Transformation, Neoplastic - genetics - pathologyen_HK
dc.subject.meshClone Cellsen_HK
dc.subject.meshDNA, Neoplasm - analysisen_HK
dc.subject.meshFatal Outcomeen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunophenotypingen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshLymphoma, B-Cell - drug therapy - genetics - pathologyen_HK
dc.subject.meshLymphoma, Large B-Cell, Diffuse - drug therapy - genetics - pathologyen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshNeoplasms, Second Primaryen_HK
dc.subject.meshRNA, Neoplasm - analysisen_HK
dc.subject.meshRNA, Viral - analysisen_HK
dc.subject.meshRNA-Binding Proteins - analysisen_HK
dc.subject.meshRibosomal Proteins - analysisen_HK
dc.titleTransformation of diffuse large B-cell lymphoma into pre-B acute lymphoblastic leukemia: Clinicopathologic features and clonal relationshipen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=35&issue=7&spage=900&epage=903&date=2004&atitle=Transformation+of+diffuse+large+B-cell+lymphoma+into+pre-B+acute+lymphoblastic+leukemia:+clinicopathologic+features+and+clonal+relationshipen_HK
dc.identifier.emailSrivastava, G: sgopesh@hkucc.hku.hken_HK
dc.identifier.emailChung, LP: lpchung@hkucc.hku.hken_HK
dc.identifier.emailKwong, YL: ylkwong@hku.hken_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.identifier.authorityChung, LP=rp00249en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.humpath.2004.04.002en_HK
dc.identifier.pmid15257558-
dc.identifier.scopuseid_2-s2.0-3142634593en_HK
dc.identifier.hkuros94891en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3142634593&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue7en_HK
dc.identifier.spage900en_HK
dc.identifier.epage903en_HK
dc.identifier.isiWOS:000223052900021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.scopusauthoridWong, KY=7404758500en_HK
dc.identifier.scopusauthoridChung, LP=24315879100en_HK
dc.identifier.scopusauthoridMa, SK=37020910400en_HK
dc.identifier.scopusauthoridWan, TS=25623981600en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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