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Article: Bcl-6 gene hypermutations in diffuse large B-cell lymphoma of primary gastric origin

TitleBcl-6 gene hypermutations in diffuse large B-cell lymphoma of primary gastric origin
Authors
Liang, RChan, WPKwong, YLChan, ACLXu, WSAu, WYSrivastava, GHo, FCS
KeywordsBcl-6 gene
Diffuse large B-cell lymphoma
Gastric lymphoma
Issue Date1997
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 1997, v. 99 n. 3, p. 668-670 How to Cite?
DOI: http://dx.doi.org/10.1046/j.1365-2141.1997.4443254.x
AbstractThe presence of the bcl-6 gene hypermutation was studied in 40 Hong Kong Chinese patients with diffuse large B-cell lymphoma. The primary sites of involvement were nodal in 18 cases and gastric in 22. Hypermutations at the E1.11 segment of bcl-6 gene were detectable in 16/22 (73%) primary gastric and 4/18 (22%) primary nodal lymphoma (P<0.01). Three of the 22 cases of primary gastric but none of the nodal lymphoma had mutations at E1.12. The proportion of hypermutated cases in the group with bcl-6 gene rearrangement was similar to that of the germ-line group (70% v 75%). High frequency of bcl-6 gene hypermutations was found in diffuse large B-cell lymphoma of the stomach and they were independent of rearrangement of the gene as detected by Southern analysis. Unlike gene rearrangement, hypermutations of the bcl-6 gene did not appear to carry any prognostic significance clinically.
Persistent Identifierhttp://hdl.handle.net/10722/77059
ISSN
0007-1048
2023 Impact Factor: 5.1
2023 SCImago Journal Rankings: 1.574
ISI Accession Number ID
WOS:A1997YK46200030
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorChan, WPen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorChan, ACLen_HK
dc.contributor.authorXu, WSen_HK
dc.contributor.authorAu, WYen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorHo, FCSen_HK
dc.date.accessioned2010-09-06T07:27:50Z-
dc.date.available2010-09-06T07:27:50Z-
dc.date.issued1997en_HK
dc.identifier.citationBritish Journal Of Haematology, 1997, v. 99 n. 3, p. 668-670en_HK
dc.identifier.issn0007-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77059-
dc.description.abstractThe presence of the bcl-6 gene hypermutation was studied in 40 Hong Kong Chinese patients with diffuse large B-cell lymphoma. The primary sites of involvement were nodal in 18 cases and gastric in 22. Hypermutations at the E1.11 segment of bcl-6 gene were detectable in 16/22 (73%) primary gastric and 4/18 (22%) primary nodal lymphoma (P<0.01). Three of the 22 cases of primary gastric but none of the nodal lymphoma had mutations at E1.12. The proportion of hypermutated cases in the group with bcl-6 gene rearrangement was similar to that of the germ-line group (70% v 75%). High frequency of bcl-6 gene hypermutations was found in diffuse large B-cell lymphoma of the stomach and they were independent of rearrangement of the gene as detected by Southern analysis. Unlike gene rearrangement, hypermutations of the bcl-6 gene did not appear to carry any prognostic significance clinically.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_HK
dc.relation.ispartofBritish Journal of Haematologyen_HK
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectBcl-6 geneen_HK
dc.subjectDiffuse large B-cell lymphomaen_HK
dc.subjectGastric lymphomaen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshBlotting, Southernen_HK
dc.subject.meshDNA-Binding Proteins - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Rearrangementen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLymphoma, B-Cell - geneticsen_HK
dc.subject.meshLymphoma, Large B-Cell, Diffuse - geneticsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMutationen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshProto-Oncogene Proteins - geneticsen_HK
dc.subject.meshProto-Oncogene Proteins c-bcl-6en_HK
dc.subject.meshStomach Neoplasms - geneticsen_HK
dc.subject.meshTranscription Factors - geneticsen_HK
dc.titleBcl-6 gene hypermutations in diffuse large B-cell lymphoma of primary gastric originen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1048&volume=99&spage=668&epage=670&date=1997&atitle=Bcl-6+gene+hypermutations+in+diffuse+large+B-cell+lymphoma+of+primary+gastric+originen_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-2141.1997.4443254.x-
dc.identifier.pmid9401082-
dc.identifier.scopuseid_2-s2.0-0030726244en_HK
dc.identifier.hkuros29763en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030726244&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume99en_HK
dc.identifier.issue3en_HK
dc.identifier.spage668en_HK
dc.identifier.epage670en_HK
dc.identifier.isiWOS:A1997YK46200030-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridChan, WP=7403918278en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridChan, ACL=16047349300en_HK
dc.identifier.scopusauthoridXu, WS=36804007100en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.scopusauthoridHo, FCS=7103408147en_HK
dc.identifier.issnl0007-1048-

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