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Article: Association of IgA nephropathy with T cell receptor constant alpha chain gene polymorptism

TitleAssociation of IgA nephropathy with T cell receptor constant alpha chain gene polymorptism
Authors
KeywordsT-cell receptor Ca
Iga nephropathy
Polymorphism
Issue Date1997
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/ajkd
Citation
American Journal of Kidney Diseases, 1997, v. 30 n. 2, p. 260-264 How to Cite?
AbstractT-cell receptor (TCR) proteins recognize a complex of an antigen-derived peptide bound to the cell surface products of the major histocompatibility complex (MHC) that could be of importance in the immunopathogenesis of IgA nephropathy (IgAN). Previous studies found no difference on TCR constant β chain gene frequencies in IgAN compared with control. Yet no study on the TCR α gene in IgAN was reported. We studied the TCR Cα gene polymorphisms by restriction fragment length polymorphism (RFLP) in 53 patients with IgAN and in comparison with 67 healthy controls. The patients were also classified into different histopathological grading (I, II, and III with increasing histological severity) and renal functions. The extracted DNA were digested with Taq I enzymes and probed with a full-length TCR-α cDNA clone p1.2α probe. A 7-kb C-α Taq 1 fragment is found in 32 of 53 patients (60.3%) compared with 26 of 67 controls (38.8%) (P < 0.05). There was no association of any polymorphic fragment, including the 7-kb fragment, with either the histological grading or renal function. It is concluded that the TCR C-α gene is associated with IgAN but not with the prognosis of the disease.
Persistent Identifierhttp://hdl.handle.net/10722/77051
ISSN
2015 Impact Factor: 6.269
2015 SCImago Journal Rankings: 2.313

 

DC FieldValueLanguage
dc.contributor.authorLi, PKT-
dc.contributor.authorPoon, P-
dc.contributor.authorPoon, ASY-
dc.contributor.authorSzeto, CC-
dc.contributor.authorYu, AWY-
dc.contributor.authorLai, KN-
dc.date.accessioned2010-09-06T07:27:45Z-
dc.date.available2010-09-06T07:27:45Z-
dc.date.issued1997-
dc.identifier.citationAmerican Journal of Kidney Diseases, 1997, v. 30 n. 2, p. 260-264-
dc.identifier.issn0272-6386-
dc.identifier.urihttp://hdl.handle.net/10722/77051-
dc.description.abstractT-cell receptor (TCR) proteins recognize a complex of an antigen-derived peptide bound to the cell surface products of the major histocompatibility complex (MHC) that could be of importance in the immunopathogenesis of IgA nephropathy (IgAN). Previous studies found no difference on TCR constant β chain gene frequencies in IgAN compared with control. Yet no study on the TCR α gene in IgAN was reported. We studied the TCR Cα gene polymorphisms by restriction fragment length polymorphism (RFLP) in 53 patients with IgAN and in comparison with 67 healthy controls. The patients were also classified into different histopathological grading (I, II, and III with increasing histological severity) and renal functions. The extracted DNA were digested with Taq I enzymes and probed with a full-length TCR-α cDNA clone p1.2α probe. A 7-kb C-α Taq 1 fragment is found in 32 of 53 patients (60.3%) compared with 26 of 67 controls (38.8%) (P < 0.05). There was no association of any polymorphic fragment, including the 7-kb fragment, with either the histological grading or renal function. It is concluded that the TCR C-α gene is associated with IgAN but not with the prognosis of the disease.-
dc.languageeng-
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/ajkd-
dc.relation.ispartofAmerican Journal of Kidney Diseases-
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in [Journal title]. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI# -
dc.subjectT-cell receptor Ca-
dc.subjectIga nephropathy-
dc.subjectPolymorphism-
dc.titleAssociation of IgA nephropathy with T cell receptor constant alpha chain gene polymorptism-
dc.typeArticle-
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0272-6386&volume=30&spage=260&epage=264&date=1997&atitle=Association+of+IgA+nephropathy+with+T+cell+receptor+constant+alpha+chain+gene+polymorptismen_HK
dc.identifier.emailLai, KN: knlai@hku.hk-
dc.identifier.authorityLai, KN=rp00324-
dc.identifier.doi10.1016/S0272-6386(97)90061-5-
dc.identifier.hkuros41498-
dc.identifier.volume30-
dc.identifier.issue2-
dc.identifier.spage260-
dc.identifier.epage264-
dc.publisher.placeUnited States-

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