Article: Serial analysis of JAK2 mutation in a patient who developed essential thrombocythemia after orthotopic liver transplantation

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TitleSerial analysis of JAK2 mutation in a patient who developed essential thrombocythemia after orthotopic liver transplantation
AuthorsAu, WY1 2
Fung, A1
Liu, CL1
Fan, ST1
Ma, SK1
Liang, R1
Kwong, YL1
KeywordsEssential thrombocythemia
JAK2
Liver transplantation
Issue Date2006
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35105
CitationAmerican Journal Of Hematology, 2006, v. 81 n. 11, p. 880-882 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ajh.20638
AbstractA 52-year-old man developed essential thrombocythemia (ET) with JAK2 V617F mutation after orthotopic liver transplantation (OLT). Retrospective analysis showed that, despite a low platelet count, the JAK2 mutation was already found at presentation 14 months before OLT. The high platelet count that would have been typical of ET might be masked by the cirrhosis-related hypersplenism. Thrombocythemia became obvious after OLT. The patient subsequently developed blastic transformation 12 months afterward, a process probably accelerated by the immunosuppression required for the OLT. © 2006 Wiley-Liss, Inc.
ISSN0361-8609
2011 Impact Factor: 4.671
2011 SCImago Journal Rankings: 0.308
DOIhttp://dx.doi.org/10.1002/ajh.20638
ISI Accession Number IDWOS:000241906700012
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorAu, WY
dc.contributor.authorFung, A
dc.contributor.authorLiu, CL
dc.contributor.authorFan, ST
dc.contributor.authorMa, SK
dc.contributor.authorLiang, R
dc.contributor.authorKwong, YL
dc.date.accessioned2010-09-06T07:27:27Z
dc.date.available2010-09-06T07:27:27Z
dc.date.issued2006
dc.description.abstractA 52-year-old man developed essential thrombocythemia (ET) with JAK2 V617F mutation after orthotopic liver transplantation (OLT). Retrospective analysis showed that, despite a low platelet count, the JAK2 mutation was already found at presentation 14 months before OLT. The high platelet count that would have been typical of ET might be masked by the cirrhosis-related hypersplenism. Thrombocythemia became obvious after OLT. The patient subsequently developed blastic transformation 12 months afterward, a process probably accelerated by the immunosuppression required for the OLT. © 2006 Wiley-Liss, Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAmerican Journal Of Hematology, 2006, v. 81 n. 11, p. 880-882 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ajh.20638
dc.identifier.doihttp://dx.doi.org/10.1002/ajh.20638
dc.identifier.epage882
dc.identifier.hkuros136803
dc.identifier.isiWOS:000241906700012
dc.identifier.issn0361-8609
2011 Impact Factor: 4.671
2011 SCImago Journal Rankings: 0.308
dc.identifier.issue11
dc.identifier.openurl
dc.identifier.pmid16929538
dc.identifier.scopuseid_2-s2.0-33749439176
dc.identifier.spage880
dc.identifier.urihttp://hdl.handle.net/10722/77024
dc.identifier.volume81
dc.languageeng
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35105
dc.publisher.placeUnited States
dc.relation.ispartofAmerican Journal of Hematology
dc.relation.referencesReferences in Scopus
dc.rightsAmerican Journal of Hematology. Copyright © John Wiley & Sons, Inc.
dc.subject.meshAmino Acid Substitution
dc.subject.meshAutopsy
dc.subject.meshFatal Outcome
dc.subject.meshHepatitis B - surgery
dc.subject.meshHumans
dc.subject.meshJanus Kinase 2 - genetics
dc.subject.meshLiver Transplantation - adverse effects
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPostoperative Complications
dc.subject.meshThrombocytosis - genetics
dc.subjectEssential thrombocythemia
dc.subjectJAK2
dc.subjectLiver transplantation
dc.titleSerial analysis of JAK2 mutation in a patient who developed essential thrombocythemia after orthotopic liver transplantation
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong