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Article: Serial analysis of JAK2 mutation in a patient who developed essential thrombocythemia after orthotopic liver transplantation

TitleSerial analysis of JAK2 mutation in a patient who developed essential thrombocythemia after orthotopic liver transplantation
Authors
KeywordsEssential thrombocythemia
JAK2
Liver transplantation
Issue Date2006
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35105
Citation
American Journal Of Hematology, 2006, v. 81 n. 11, p. 880-882 How to Cite?
Abstract
A 52-year-old man developed essential thrombocythemia (ET) with JAK2 V617F mutation after orthotopic liver transplantation (OLT). Retrospective analysis showed that, despite a low platelet count, the JAK2 mutation was already found at presentation 14 months before OLT. The high platelet count that would have been typical of ET might be masked by the cirrhosis-related hypersplenism. Thrombocythemia became obvious after OLT. The patient subsequently developed blastic transformation 12 months afterward, a process probably accelerated by the immunosuppression required for the OLT. © 2006 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/77024
ISSN
2013 Impact Factor: 3.477
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong
DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorFung, Aen_HK
dc.contributor.authorLiu, CLen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:27:27Z-
dc.date.available2010-09-06T07:27:27Z-
dc.date.issued2006en_HK
dc.identifier.citationAmerican Journal Of Hematology, 2006, v. 81 n. 11, p. 880-882en_HK
dc.identifier.issn0361-8609en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77024-
dc.description.abstractA 52-year-old man developed essential thrombocythemia (ET) with JAK2 V617F mutation after orthotopic liver transplantation (OLT). Retrospective analysis showed that, despite a low platelet count, the JAK2 mutation was already found at presentation 14 months before OLT. The high platelet count that would have been typical of ET might be masked by the cirrhosis-related hypersplenism. Thrombocythemia became obvious after OLT. The patient subsequently developed blastic transformation 12 months afterward, a process probably accelerated by the immunosuppression required for the OLT. © 2006 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35105en_HK
dc.relation.ispartofAmerican Journal of Hematologyen_HK
dc.rightsAmerican Journal of Hematology. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectEssential thrombocythemiaen_HK
dc.subjectJAK2en_HK
dc.subjectLiver transplantationen_HK
dc.subject.meshAmino Acid Substitutionen_HK
dc.subject.meshAutopsyen_HK
dc.subject.meshFatal Outcomeen_HK
dc.subject.meshHepatitis B - surgeryen_HK
dc.subject.meshHumansen_HK
dc.subject.meshJanus Kinase 2 - geneticsen_HK
dc.subject.meshLiver Transplantation - adverse effectsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPostoperative Complicationsen_HK
dc.subject.meshThrombocytosis - geneticsen_HK
dc.titleSerial analysis of JAK2 mutation in a patient who developed essential thrombocythemia after orthotopic liver transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0361-8609&volume=81&issue=1&spage=880&epage=882&date=2006&atitle=Serial+analysis+of+JAK2+mutation+in+a+patient+who+developed+essential+thrombocythemia+after+orthotopic+liver+transplantationen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailLiang, R: rliang@hku.hken_HK
dc.identifier.emailKwong, YL: ylkwong@hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/ajh.20638en_HK
dc.identifier.pmid16929538en_HK
dc.identifier.scopuseid_2-s2.0-33749439176en_HK
dc.identifier.hkuros136803en_HK
dc.identifier.hkuros124840-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33749439176&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume81en_HK
dc.identifier.issue11en_HK
dc.identifier.spage880en_HK
dc.identifier.epage882en_HK
dc.identifier.isiWOS:000241906700012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridFung, A=7101926728en_HK
dc.identifier.scopusauthoridLiu, CL=7409789712en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridMa, SK=9042504200en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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