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Article: Revisiting the natural history of chronic hepatitis B: Impact of new concepts on clinical management

TitleRevisiting the natural history of chronic hepatitis B: Impact of new concepts on clinical management
Authors
Issue Date2007
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal Of Gastroenterology And Hepatology, 2007, v. 22 n. 7, p. 973-976 How to Cite?
AbstractAppropriate treatment for chronic hepatitis B (CHB) to prevent disease progression and clinical complications requires an accurate knowledge of the natural history of this disorder. In patients who acquire the disease in early life, as is the situation in Asian CHB patients, complications of CHB continue to develop because of the prolonged insidious damage to the liver, even in the low viremic phase. Hepatitis B e antigen seroconversion with hepatitis B virus (HBV) DNA levels just below 105 copies/mL may not be an adequate treatment endpoint for Asian CHB patients. Furthermore, it has been shown that patients with mild elevation of alanine aminotransferase (ALT) levels are already at considerable risk of development of complications. More recent studies have shown that in order to move towards a better disease outcome, CHB patients should have HBV DNA levels at least less than 103 copies/mL, with ALT levels preferably in the range of less than 0.5 times the upper limit of the normal range. Therefore, prolonged, adequate suppression of viral replication should be the practical goal for the treatment of CHB disease in the Asian population. © 2007 The Author.
Persistent Identifierhttp://hdl.handle.net/10722/77005
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, MFen_HK
dc.date.accessioned2010-09-06T07:27:14Z-
dc.date.available2010-09-06T07:27:14Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2007, v. 22 n. 7, p. 973-976en_HK
dc.identifier.issn0815-9319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77005-
dc.description.abstractAppropriate treatment for chronic hepatitis B (CHB) to prevent disease progression and clinical complications requires an accurate knowledge of the natural history of this disorder. In patients who acquire the disease in early life, as is the situation in Asian CHB patients, complications of CHB continue to develop because of the prolonged insidious damage to the liver, even in the low viremic phase. Hepatitis B e antigen seroconversion with hepatitis B virus (HBV) DNA levels just below 105 copies/mL may not be an adequate treatment endpoint for Asian CHB patients. Furthermore, it has been shown that patients with mild elevation of alanine aminotransferase (ALT) levels are already at considerable risk of development of complications. More recent studies have shown that in order to move towards a better disease outcome, CHB patients should have HBV DNA levels at least less than 103 copies/mL, with ALT levels preferably in the range of less than 0.5 times the upper limit of the normal range. Therefore, prolonged, adequate suppression of viral replication should be the practical goal for the treatment of CHB disease in the Asian population. © 2007 The Author.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_HK
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshHepatitis B, Chronic - blood - complications - immunology - virologyen_HK
dc.subject.meshHumansen_HK
dc.titleRevisiting the natural history of chronic hepatitis B: Impact of new concepts on clinical managementen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0815-9319&volume=22&issue=7&spage=973&epage=6&date=2007&atitle=Revisiting+the+natural+history+of+chronic+hepatitis+B:+Impact+of+new+concepts+on+clinical+management.en_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1746.2007.04938.xen_HK
dc.identifier.pmid17489961-
dc.identifier.scopuseid_2-s2.0-34347379602en_HK
dc.identifier.hkuros130660en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34347379602&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue7en_HK
dc.identifier.spage973en_HK
dc.identifier.epage976en_HK
dc.identifier.isiWOS:000247606700007-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.citeulike1425826-

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