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Article: The spectrum of chronic lymphoproliferative disorders in Chinese people: An analysis of 64 cases

TitleThe spectrum of chronic lymphoproliferative disorders in Chinese people: An analysis of 64 cases
Authors
KeywordsChinese people
chronic lymphocytic leukemia
chronic lymphoproliferative disorders
large granular lymphocytic leukemia
Issue Date1994
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 1994, v. 74 n. 1, p. 174-181 How to Cite?
AbstractBackground. Chronic lymphoproliferative disorders are considered rare in Oriental patients and are thought to constitute only 2% of all leukemias in these patients, compared to 20-30% in Western patients. We conducted a retrospective analysis of Chinese patients with chronic lymphoproliferative disorders to define the frequency and spectrum of these disorders. Methods. A consecutive series of Chinese patients with leukemia and lymphoproliferative disorders seen at two regional hospitals in Hong Kong were analyzed retrospectively. The diagnosis of chronic lymphoproliferative disorders was based on morphologic and immunologic criteria proposed by the French- American-British Cooperative Study Group. Results. Sixty-four Chinese patients with chronic lymphoproliferative disorders were identified, and these patients constituted 19% of a total of 342 cases of leukemia diagnosed in 3 years. Chronic lymphocytic leukemia was the most common form, occurring at a frequency of 12.5% of all leukemias. The clinicopathologic features of these patients were similar to those of Western patients, except that Chinese patients tended to present with more advanced (Rai's Stages III and IV; Binet's Stage C) and bulky (splenomegaly >9 cm) disease, and expressed λ light chain about six times more frequently. Other chronic lymphoproliferative disorders identified in this study included prolymphocytic leukemia, mantle zone lymphoma, hairy cell leukemia, splenic lymphoma with villous lymphocytes, large granular lymphocyte leukemia, and Sezary syndrome. The authors did not identify any case of human T-cell lymphotropic virus-I-related lymphoproliferative disorders within the study period. Conclusion. In addition to providing the frequencies of various chronic lymphoproliferative disorders in southern Chinese people, this study also showed that these disorders no longer should be considered rare in this population. Inherent biologic differences between lymphoproliferative disorders in Chinese and Western patients also may exist.
Persistent Identifierhttp://hdl.handle.net/10722/76997
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorWong, KFen_HK
dc.contributor.authorChan, LCen_HK
dc.contributor.authorLiang, RHSen_HK
dc.contributor.authorChan, JKCen_HK
dc.contributor.authorWei, Den_HK
dc.contributor.authorChiu, EKWen_HK
dc.contributor.authorChan, CHen_HK
dc.contributor.authorTodd, Den_HK
dc.contributor.authorChan, TKen_HK
dc.date.accessioned2010-09-06T07:27:09Z-
dc.date.available2010-09-06T07:27:09Z-
dc.date.issued1994en_HK
dc.identifier.citationCancer, 1994, v. 74 n. 1, p. 174-181en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/76997-
dc.description.abstractBackground. Chronic lymphoproliferative disorders are considered rare in Oriental patients and are thought to constitute only 2% of all leukemias in these patients, compared to 20-30% in Western patients. We conducted a retrospective analysis of Chinese patients with chronic lymphoproliferative disorders to define the frequency and spectrum of these disorders. Methods. A consecutive series of Chinese patients with leukemia and lymphoproliferative disorders seen at two regional hospitals in Hong Kong were analyzed retrospectively. The diagnosis of chronic lymphoproliferative disorders was based on morphologic and immunologic criteria proposed by the French- American-British Cooperative Study Group. Results. Sixty-four Chinese patients with chronic lymphoproliferative disorders were identified, and these patients constituted 19% of a total of 342 cases of leukemia diagnosed in 3 years. Chronic lymphocytic leukemia was the most common form, occurring at a frequency of 12.5% of all leukemias. The clinicopathologic features of these patients were similar to those of Western patients, except that Chinese patients tended to present with more advanced (Rai's Stages III and IV; Binet's Stage C) and bulky (splenomegaly >9 cm) disease, and expressed λ light chain about six times more frequently. Other chronic lymphoproliferative disorders identified in this study included prolymphocytic leukemia, mantle zone lymphoma, hairy cell leukemia, splenic lymphoma with villous lymphocytes, large granular lymphocyte leukemia, and Sezary syndrome. The authors did not identify any case of human T-cell lymphotropic virus-I-related lymphoproliferative disorders within the study period. Conclusion. In addition to providing the frequencies of various chronic lymphoproliferative disorders in southern Chinese people, this study also showed that these disorders no longer should be considered rare in this population. Inherent biologic differences between lymphoproliferative disorders in Chinese and Western patients also may exist.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.subjectChinese peopleen_HK
dc.subjectchronic lymphocytic leukemiaen_HK
dc.subjectchronic lymphoproliferative disordersen_HK
dc.subjectlarge granular lymphocytic leukemiaen_HK
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshChina - ethnology-
dc.subject.meshLymphoproliferative Disorders - epidemiology - pathology-
dc.titleThe spectrum of chronic lymphoproliferative disorders in Chinese people: An analysis of 64 casesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=74&issue=1&spage=174&epage=181&date=1994&atitle=The+spectrum+of+chronic+lymphoproliferative+disorders+in+Chinese+people:+an+analysis+of+64+casesen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.emailLiang, RHS:rliang@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.identifier.authorityLiang, RHS=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/1097-0142(19940701)74:1<174::AID-CNCR2820740128>3.0.CO;2-0en_HK
dc.identifier.pmid8004573-
dc.identifier.scopuseid_2-s2.0-0028304725en_HK
dc.identifier.hkuros5606en_HK
dc.identifier.volume74en_HK
dc.identifier.issue1en_HK
dc.identifier.spage174en_HK
dc.identifier.epage181en_HK
dc.identifier.isiWOS:A1994NT71500027-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridWong, KF=7404759860en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK
dc.identifier.scopusauthoridLiang, RHS=26643224900en_HK
dc.identifier.scopusauthoridChan, JKC=7403287069en_HK
dc.identifier.scopusauthoridWei, D=7202909037en_HK
dc.identifier.scopusauthoridChiu, EKW=24827833600en_HK
dc.identifier.scopusauthoridChan, CH=8700345500en_HK
dc.identifier.scopusauthoridTodd, D=7201388182en_HK
dc.identifier.scopusauthoridChan, TK=7402687762en_HK

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