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Article: Effect of buyang huanwu decoction drug serum on expression of p53 and p21 genes in cultured rat's cerebral cortical neuron after hypoxia in vitro

TitleEffect of buyang huanwu decoction drug serum on expression of p53 and p21 genes in cultured rat's cerebral cortical neuron after hypoxia in vitro
Authors
Issue Date2004
PublisherZhongguo Zhong-Xiyi Jiehe Zazhi. The Journal's web site is located at http://zxyjh.periodicals.net.cn/
Citation
Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal Of Integrated Traditional And Western Medicine / Zhongguo Zhong Xi Yi Jie He Xue Hui, Zhongguo Zhong Yi Yan Jiu Yuan Zhu Ban, 2004, v. 24 n. 2, p. 133-135 How to Cite?
AbstractOBJECTIVE: To explore the effect of Buyang Huanwu decoction (BHD) drug serum on rat's in vitro cultured cerebral cortical neuron apoptosis induced by hypoxia, and on the expression of p53 and p21 genes in hypoxia process. METHODS: The model of hypoxia neuron apoptosis was established adopting Daniel method and treated with BHD drug serum. The neuron apoptosis rate was determined by flow cytometry with propidium iodide staining, the p53 and p21 gene expression was tested by immunohistochemical method with flow cytometry. RESULTS: BHD could significantly inhibit the neuron apoptosis induced by hypoxia and down-regulate the expressions of p53 and p21 genes. CONCLUSION: BHD shows inhibition on neuron hypoxia apoptosis and down-regulating of the p53 and p21 gene expression is one of its mechanisms.
Persistent Identifierhttp://hdl.handle.net/10722/76996
ISSN
2015 SCImago Journal Rankings: 0.140

 

DC FieldValueLanguage
dc.contributor.authorQu, HDen_HK
dc.contributor.authorTong, Len_HK
dc.contributor.authorShen, JGen_HK
dc.date.accessioned2010-09-06T07:27:09Z-
dc.date.available2010-09-06T07:27:09Z-
dc.date.issued2004en_HK
dc.identifier.citationZhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal Of Integrated Traditional And Western Medicine / Zhongguo Zhong Xi Yi Jie He Xue Hui, Zhongguo Zhong Yi Yan Jiu Yuan Zhu Ban, 2004, v. 24 n. 2, p. 133-135en_HK
dc.identifier.issn1003-5370en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76996-
dc.description.abstractOBJECTIVE: To explore the effect of Buyang Huanwu decoction (BHD) drug serum on rat's in vitro cultured cerebral cortical neuron apoptosis induced by hypoxia, and on the expression of p53 and p21 genes in hypoxia process. METHODS: The model of hypoxia neuron apoptosis was established adopting Daniel method and treated with BHD drug serum. The neuron apoptosis rate was determined by flow cytometry with propidium iodide staining, the p53 and p21 gene expression was tested by immunohistochemical method with flow cytometry. RESULTS: BHD could significantly inhibit the neuron apoptosis induced by hypoxia and down-regulate the expressions of p53 and p21 genes. CONCLUSION: BHD shows inhibition on neuron hypoxia apoptosis and down-regulating of the p53 and p21 gene expression is one of its mechanisms.en_HK
dc.languageengen_HK
dc.publisherZhongguo Zhong-Xiyi Jiehe Zazhi. The Journal's web site is located at http://zxyjh.periodicals.net.cn/en_HK
dc.relation.ispartofZhongguo zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu banen_HK
dc.subject.meshAnimals-
dc.subject.meshCerebral Cortex - pathology-
dc.subject.meshDrugs, Chinese Herbal - pharmacology-
dc.subject.meshOncogene Protein p21(ras) - biosynthesis - genetics-
dc.subject.meshTumor Suppressor Protein p53 - biosynthesis - genetics-
dc.titleEffect of buyang huanwu decoction drug serum on expression of p53 and p21 genes in cultured rat's cerebral cortical neuron after hypoxia in vitroen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1003-5370&volume=24&issue=2&spage=133&epage=135&date=2004&atitle=Effect+of+buyang+huanwu+decoction+drug+serum+on+expression+of+p53+and+p21+genes+in+cultured+rat%27s+cerebral+cortical+neuron+after+hypoxia+in+vitro-
dc.identifier.emailShen, JG: shenjg@hku.hken_HK
dc.identifier.authorityShen, JG=rp00487en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid15015447-
dc.identifier.scopuseid_2-s2.0-3042820900en_HK
dc.identifier.hkuros88466en_HK
dc.identifier.volume24en_HK
dc.identifier.issue2en_HK
dc.identifier.spage133en_HK
dc.identifier.epage135en_HK
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridQu, HD=7101947180en_HK
dc.identifier.scopusauthoridTong, L=7201891650en_HK
dc.identifier.scopusauthoridShen, JG=7404929947en_HK

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