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Article: Interaction of cigarette smoking with cyclooxygenase-2 on ulcerative colitis-associated neoplasia in mice

TitleInteraction of cigarette smoking with cyclooxygenase-2 on ulcerative colitis-associated neoplasia in mice
Authors
Issue Date2007
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.asp
Citation
Cancer Investigation, 2007, v. 25 n. 8, p. 750-757 How to Cite?
AbstractThe interactions of cigarette smoking with COX-2 on colitis and colitis-associated adenoma formation were studied. Mice were induced with colitis and exposed to cigarette smoke (CS) and/or SC236 (a COX-2 inhibitor). Results indicated that CS did not alter acute colonic inflammation. Addition of SC236 abolished the induction of proliferation and oxidative damage by colitis. Chronic SC236 treatment abolished the promoting effect of CS on colonic adenoma formation, via suppression of COX-2- and VEGF-mediated proliferation and angiogenesis, and reversed bcl-2-mediated inhibition of apoptosis by CS. To conclude, COX-2 inhibitor could be an implication on cancer prevention in smokers with chronic colitis. Copyright © Informa Healthcare USA, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/76976
ISSN
2015 Impact Factor: 2.231
2015 SCImago Journal Rankings: 0.991
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, ESLen_HK
dc.contributor.authorYe, YNen_HK
dc.contributor.authorShin, VYen_HK
dc.contributor.authorWu, WKKen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2010-09-06T07:26:56Z-
dc.date.available2010-09-06T07:26:56Z-
dc.date.issued2007en_HK
dc.identifier.citationCancer Investigation, 2007, v. 25 n. 8, p. 750-757en_HK
dc.identifier.issn0735-7907en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76976-
dc.description.abstractThe interactions of cigarette smoking with COX-2 on colitis and colitis-associated adenoma formation were studied. Mice were induced with colitis and exposed to cigarette smoke (CS) and/or SC236 (a COX-2 inhibitor). Results indicated that CS did not alter acute colonic inflammation. Addition of SC236 abolished the induction of proliferation and oxidative damage by colitis. Chronic SC236 treatment abolished the promoting effect of CS on colonic adenoma formation, via suppression of COX-2- and VEGF-mediated proliferation and angiogenesis, and reversed bcl-2-mediated inhibition of apoptosis by CS. To conclude, COX-2 inhibitor could be an implication on cancer prevention in smokers with chronic colitis. Copyright © Informa Healthcare USA, Inc.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.aspen_HK
dc.relation.ispartofCancer Investigationen_HK
dc.rightsCancer Investigation. Copyright © Informa Healthcare.en_HK
dc.subject.meshAdenoma - etiology - prevention & controlen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshApoptosisen_HK
dc.subject.meshCell Proliferationen_HK
dc.subject.meshColitis, Ulcerative - complicationsen_HK
dc.subject.meshColonic Neoplasms - etiology - prevention & controlen_HK
dc.subject.meshCyclooxygenase 2 - physiologyen_HK
dc.subject.meshDextran Sulfateen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred BALB Cen_HK
dc.subject.meshPyrazoles - therapeutic useen_HK
dc.subject.meshSmoking - adverse effectsen_HK
dc.subject.meshSulfonamides - therapeutic useen_HK
dc.titleInteraction of cigarette smoking with cyclooxygenase-2 on ulcerative colitis-associated neoplasia in miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0735-7907&volume=25&issue=8&spage=750&epage=7&date=2007&atitle=Interaction+of+cigarette+smoking+with+cyclooxygenase-2+on+ulcerative+colitis-associated+neoplasia+in+mice.en_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/07357900701563897en_HK
dc.identifier.pmid18058473-
dc.identifier.scopuseid_2-s2.0-36849013083en_HK
dc.identifier.hkuros150066en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-36849013083&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue8en_HK
dc.identifier.spage750en_HK
dc.identifier.epage757en_HK
dc.identifier.isiWOS:000252151800016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, ESL=7202240071en_HK
dc.identifier.scopusauthoridYe, YN=7401627402en_HK
dc.identifier.scopusauthoridShin, VY=7003491170en_HK
dc.identifier.scopusauthoridWu, WKK=18345422600en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridCho, CH=14067000400en_HK

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