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Article: Tumor necrosis factor alpha promoter polymorphism and the risk of chronic lymphocytic leukemia and myeloma in the Chinese population

TitleTumor necrosis factor alpha promoter polymorphism and the risk of chronic lymphocytic leukemia and myeloma in the Chinese population
Authors
Issue Date2006
PublisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lal
Citation
Leukemia And Lymphoma, 2006, v. 47 n. 10, p. 2189-2193 How to Cite?
AbstractThe - 308 GA promoter polymorphism of tumor necrosis factor alpha (TNFα) has been reported to be associated with an increased risk of lymphoid malignancies in Caucasians. We studied the incidence and prognostic significance of this polymorphism in Chinese patients with plasma cell myeloma (PCM), chronic lymphocytic leukemia (CLL) and lymphomas. Despite a far lower incidence of PCM and CLL in the Chinese population compared with Caucasians, the rates of TNFα - 308A were similar to those in Caucasians, both in the study and control populations. Similarly, there was no increased rate of TNFα - 308A in all the lymphomas studied, irrespective of lineage. However, TNFα - 308A is significantly associated with female CLL cases and confers a strong negative prognostic impact for Chinese CLL. These argue for a possible biological role for increased TNFα production in CLL progression in low-risk individuals.
Persistent Identifierhttp://hdl.handle.net/10722/76954
ISSN
2015 Impact Factor: 3.093
2015 SCImago Journal Rankings: 1.202
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorFung, Aen_HK
dc.contributor.authorWong, KFen_HK
dc.contributor.authorChan, CHen_HK
dc.contributor.authorLiang, Ren_HK
dc.date.accessioned2010-09-06T07:26:42Z-
dc.date.available2010-09-06T07:26:42Z-
dc.date.issued2006en_HK
dc.identifier.citationLeukemia And Lymphoma, 2006, v. 47 n. 10, p. 2189-2193en_HK
dc.identifier.issn1042-8194en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76954-
dc.description.abstractThe - 308 GA promoter polymorphism of tumor necrosis factor alpha (TNFα) has been reported to be associated with an increased risk of lymphoid malignancies in Caucasians. We studied the incidence and prognostic significance of this polymorphism in Chinese patients with plasma cell myeloma (PCM), chronic lymphocytic leukemia (CLL) and lymphomas. Despite a far lower incidence of PCM and CLL in the Chinese population compared with Caucasians, the rates of TNFα - 308A were similar to those in Caucasians, both in the study and control populations. Similarly, there was no increased rate of TNFα - 308A in all the lymphomas studied, irrespective of lineage. However, TNFα - 308A is significantly associated with female CLL cases and confers a strong negative prognostic impact for Chinese CLL. These argue for a possible biological role for increased TNFα production in CLL progression in low-risk individuals.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lalen_HK
dc.relation.ispartofLeukemia and Lymphomaen_HK
dc.rightsLeukemia and Lymphoma. Copyright © Informa Healthcare.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCell Lineageen_HK
dc.subject.meshChinaen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell - genetics - metabolism - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMultiple Myeloma - genetics - metabolism - pathologyen_HK
dc.subject.meshPolymorphism, Geneticen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshPromoter Regions, Geneticen_HK
dc.subject.meshTumor Necrosis Factor-alpha - genetics - physiologyen_HK
dc.titleTumor necrosis factor alpha promoter polymorphism and the risk of chronic lymphocytic leukemia and myeloma in the Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1042-8194&volume=47&issue=10&spage=2189&epage=2193&date=2006&atitle=Tumor+necrosis+factor+alpha+promoter+polymorphism+and+the+risk+of+chronic+lymphocytic+leukemia+and+myeloma+in+the+Chinese+populationen_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/10428190600758645en_HK
dc.identifier.pmid17071494-
dc.identifier.scopuseid_2-s2.0-33750471622en_HK
dc.identifier.hkuros136883en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750471622&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47en_HK
dc.identifier.issue10en_HK
dc.identifier.spage2189en_HK
dc.identifier.epage2193en_HK
dc.identifier.isiWOS:000241581800031-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridFung, A=7101926728en_HK
dc.identifier.scopusauthoridWong, KF=7404759860en_HK
dc.identifier.scopusauthoridChan, CH=8700345500en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK

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