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Article: Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease

TitleIncidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease
Authors
KeywordsAspirin
Coronary artery disease
Gastrointestinal bleeding
Issue Date2006
PublisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
Citation
World Journal Of Gastroenterology, 2006, v. 12 n. 19, p. 2923-2927 How to Cite?
AbstractAim: The use of low-dose aspirin to prevent cardiovascular disease events is well established. However, the incidence and predictors of upper gastrointestinal bleeding (UGIB) with its use are unknown. We studied prospectively the incidence and outcome of peptic ulceration in low-dose aspirin users. Methods: A total of 991 patients with coronary artery disease (CAD) on low-dose aspirin were prospectively followed-up for two years for the occurrence and clinical features of first hospitalized episode of UGIB. Results: UGIB had a bimodal presentation with 45% occurring within four months of aspirin initiation and had an overall prevalence of 1.5% per year. There was no UGIB-related death. Hypertension (OR = 4.6, 95%CI 1.5 - 14.7, P = 0.009), history of peptic ulceration (OR = 3.1, 95%CI 1.1 - 9.0, P = 0.039), tertiary education (OR = 3.08, 95%CI 1.1 - 9.0, P = 0.039) and higher lean body mass (P = 0.016) were independent factors associated with UGIB. Use of nitrate did not reduce UGIB. Conclusion: The incidence of UGIB in patients with CAD on long-term low-dose aspirin is low, but is accompanied with significant morbidity. With prolonged use of aspirin, UGIB continues to be a problem for those with risk factors and especially in patients with a history of peptic ulcers, in which UGIB tends to occur early after aspirin therapy. © 2006 The WJG Press. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/76950
ISSN
2015 Impact Factor: 2.787
2015 SCImago Journal Rankings: 1.076
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, Wen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorChen, WHen_HK
dc.contributor.authorTse, HFen_HK
dc.contributor.authorLee, PYen_HK
dc.contributor.authorLai, KCen_HK
dc.contributor.authorLi, SWen_HK
dc.contributor.authorNg, Men_HK
dc.contributor.authorLam, KFen_HK
dc.contributor.authorCheng, Xen_HK
dc.contributor.authorLau, CPen_HK
dc.date.accessioned2010-09-06T07:26:40Z-
dc.date.available2010-09-06T07:26:40Z-
dc.date.issued2006en_HK
dc.identifier.citationWorld Journal Of Gastroenterology, 2006, v. 12 n. 19, p. 2923-2927en_HK
dc.identifier.issn1007-9327en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76950-
dc.description.abstractAim: The use of low-dose aspirin to prevent cardiovascular disease events is well established. However, the incidence and predictors of upper gastrointestinal bleeding (UGIB) with its use are unknown. We studied prospectively the incidence and outcome of peptic ulceration in low-dose aspirin users. Methods: A total of 991 patients with coronary artery disease (CAD) on low-dose aspirin were prospectively followed-up for two years for the occurrence and clinical features of first hospitalized episode of UGIB. Results: UGIB had a bimodal presentation with 45% occurring within four months of aspirin initiation and had an overall prevalence of 1.5% per year. There was no UGIB-related death. Hypertension (OR = 4.6, 95%CI 1.5 - 14.7, P = 0.009), history of peptic ulceration (OR = 3.1, 95%CI 1.1 - 9.0, P = 0.039), tertiary education (OR = 3.08, 95%CI 1.1 - 9.0, P = 0.039) and higher lean body mass (P = 0.016) were independent factors associated with UGIB. Use of nitrate did not reduce UGIB. Conclusion: The incidence of UGIB in patients with CAD on long-term low-dose aspirin is low, but is accompanied with significant morbidity. With prolonged use of aspirin, UGIB continues to be a problem for those with risk factors and especially in patients with a history of peptic ulcers, in which UGIB tends to occur early after aspirin therapy. © 2006 The WJG Press. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htmen_HK
dc.relation.ispartofWorld Journal of Gastroenterologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAspirinen_HK
dc.subjectCoronary artery diseaseen_HK
dc.subjectGastrointestinal bleedingen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAspirin - adverse effects - therapeutic useen_HK
dc.subject.meshBody Mass Indexen_HK
dc.subject.meshComorbidityen_HK
dc.subject.meshCoronary Artery Disease - epidemiology - prevention & controlen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGastrointestinal Hemorrhage - chemically induced - epidemiology - physiopathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - complicationsen_HK
dc.subject.meshIncidenceen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMultivariate Analysisen_HK
dc.subject.meshOdds Ratioen_HK
dc.subject.meshPeptic Ulcer - complicationsen_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshRecurrence - prevention & controlen_HK
dc.subject.meshRisk Factorsen_HK
dc.titleIncidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1007-9327&volume=12&issue=18&spage=2923&epage=2927&date=2006&atitle=Incidence+and+predictors+of+upper+gastrointestinal+bleeding+in+patients+receiving+low-dose+aspirin+for+secondary+prevention+of+cardiovascular+events+in+patients+with+coronary+artery+diseaseen_HK
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_HK
dc.identifier.emailLam, KF: hrntlkf@hkucc.hku.hken_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.identifier.authorityLam, KF=rp00718en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3748/wjg.v12.i18.2923-
dc.identifier.pmid16718820-
dc.identifier.pmcidPMC4087812-
dc.identifier.scopuseid_2-s2.0-33744496293en_HK
dc.identifier.hkuros115898en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33744496293&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue19en_HK
dc.identifier.spage2923en_HK
dc.identifier.epage2927en_HK
dc.identifier.isiWOS:000239996900019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNg, W=7401613562en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridChen, WH=7409637978en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridLee, PY=8933949600en_HK
dc.identifier.scopusauthoridLai, KC=7402135595en_HK
dc.identifier.scopusauthoridLi, SW=13807028100en_HK
dc.identifier.scopusauthoridNg, M=7202076310en_HK
dc.identifier.scopusauthoridLam, KF=8948421200en_HK
dc.identifier.scopusauthoridCheng, X=37044433500en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK

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