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Article: Ethanol reduces p38 kinase activation and cyclin D1 protein expression after partial hepatectomy in rats

TitleEthanol reduces p38 kinase activation and cyclin D1 protein expression after partial hepatectomy in rats
Authors
KeywordsCyclin D1
Ethanol
Liver regeneration
MAPK
p38 kinase
PCNA
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
Citation
Journal Of Hepatology, 2006, v. 44 n. 2, p. 375-382 How to Cite?
AbstractBackground/Aims: Chronic ethanol consumption inhibits liver regeneration. We examined the effects of chronic ethanol consumption on two mitogen-activated protein kinases in relation to induction of cell cycle proteins after partial hepatectomy (PH). Methods: Male Wistar rats were ethanol-fed (EF) or pair-fed (PF) for 16 weeks before PH. Hepatic activation of extracellular signal regulated kinase (ERK)1/2, p38 kinase and expression of cyclinD1, cyclin-dependent kinase-4 (cdk4) and proliferating cell nuclear antigen (PCNA) were studied. Results: In PF rats, PH-induced p38 activation was evident at 2 h and was maximal at 12 h. There was a close temporal relationship between p38 activation, cyclin D1 and PCNA expression. Alcohol exposure reduced p38 activation, cyclin D1 and PCNA, each by ∼50%. ERK1/2 activation occurred during the first 2 h post-PH in both EF and PF rats, and there was no later increase in PF rats. In vivo inhibition of p38 suppressed PCNA expression whereas the effect of ERK1/2 inhibition was inconsistent. Conclusions: p38 kinase activation is linked temporally with cyclin D1 expression after PH and appears to exert cell cycle control in the adult liver. p38 signaling also appears to be a target for the inhibitory effect of chronic alcohol on liver regeneration. © 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/76934
ISSN
2015 Impact Factor: 10.59
2015 SCImago Journal Rankings: 4.570
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHsu, MKHen_HK
dc.contributor.authorQiao, Len_HK
dc.contributor.authorHo, Ven_HK
dc.contributor.authorZhang, BHen_HK
dc.contributor.authorZhang, Hen_HK
dc.contributor.authorTeoh, Nen_HK
dc.contributor.authorDent, Pen_HK
dc.contributor.authorFarrell, GCen_HK
dc.date.accessioned2010-09-06T07:26:29Z-
dc.date.available2010-09-06T07:26:29Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Hepatology, 2006, v. 44 n. 2, p. 375-382en_HK
dc.identifier.issn0168-8278en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76934-
dc.description.abstractBackground/Aims: Chronic ethanol consumption inhibits liver regeneration. We examined the effects of chronic ethanol consumption on two mitogen-activated protein kinases in relation to induction of cell cycle proteins after partial hepatectomy (PH). Methods: Male Wistar rats were ethanol-fed (EF) or pair-fed (PF) for 16 weeks before PH. Hepatic activation of extracellular signal regulated kinase (ERK)1/2, p38 kinase and expression of cyclinD1, cyclin-dependent kinase-4 (cdk4) and proliferating cell nuclear antigen (PCNA) were studied. Results: In PF rats, PH-induced p38 activation was evident at 2 h and was maximal at 12 h. There was a close temporal relationship between p38 activation, cyclin D1 and PCNA expression. Alcohol exposure reduced p38 activation, cyclin D1 and PCNA, each by ∼50%. ERK1/2 activation occurred during the first 2 h post-PH in both EF and PF rats, and there was no later increase in PF rats. In vivo inhibition of p38 suppressed PCNA expression whereas the effect of ERK1/2 inhibition was inconsistent. Conclusions: p38 kinase activation is linked temporally with cyclin D1 expression after PH and appears to exert cell cycle control in the adult liver. p38 signaling also appears to be a target for the inhibitory effect of chronic alcohol on liver regeneration. © 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhepen_HK
dc.relation.ispartofJournal of Hepatologyen_HK
dc.rightsJournal of Hepatology. Copyright © Elsevier BV.en_HK
dc.subjectCyclin D1en_HK
dc.subjectEthanolen_HK
dc.subjectLiver regenerationen_HK
dc.subjectMAPKen_HK
dc.subjectp38 kinaseen_HK
dc.subjectPCNAen_HK
dc.titleEthanol reduces p38 kinase activation and cyclin D1 protein expression after partial hepatectomy in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0168-8278&volume=44&spage=375&epage=82&date=2006&atitle=Ethanol+reduces+p38+kinase+activation+and+cyclin+D1+protein+expression+after+partial+hepatectomy+in+ratsen_HK
dc.identifier.emailQiao, L: lq8688@hotmail.comen_HK
dc.identifier.authorityQiao, L=rp00513en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jhep.2005.07.031en_HK
dc.identifier.pmid16226824-
dc.identifier.scopuseid_2-s2.0-30344445363en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-30344445363&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue2en_HK
dc.identifier.spage375en_HK
dc.identifier.epage382en_HK
dc.identifier.isiWOS:000235291000018-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridHsu, MKH=11139926700en_HK
dc.identifier.scopusauthoridQiao, L=7202151719en_HK
dc.identifier.scopusauthoridHo, V=11139709300en_HK
dc.identifier.scopusauthoridZhang, BH=7406904271en_HK
dc.identifier.scopusauthoridZhang, H=7409191451en_HK
dc.identifier.scopusauthoridTeoh, N=6603270763en_HK
dc.identifier.scopusauthoridDent, P=7102148976en_HK
dc.identifier.scopusauthoridFarrell, GC=7102979833en_HK

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