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Article: An update on obstructive sleep apnea and the metabolic syndrome

TitleAn update on obstructive sleep apnea and the metabolic syndrome
Authors
Issue Date2007
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.co-pulmonarymedicine.com
Citation
Current Opinion In Pulmonary Medicine, 2007, v. 13 n. 6, p. 484-489 How to Cite?
AbstractPURPOSE OF REVIEW: Patients with obstructive sleep apnea are often overweight or obese, and they frequently exhibit metabolic aberrations, collectively known as the metabolic syndrome, an established cardiovascular risk factor. We review recent data on the relationship between obstructive sleep apnea and metabolic syndrome or its components, including abdominal obesity, insulin resistance, hypertension, and dyslipidemia. RECENT FINDINGS: There is accumulating evidence for an independent association between obstructive sleep apnea and metabolic syndrome or its components. Recent epidemiologic and clinical data suggest a causal role of severe obstructive sleep apnea in development of hypertension, but findings for insulin resistance and dyslipidemia are controversial. Visceral obesity remains a confounding issue in analyses. Animal models and translational studies indicate that obstructive sleep apnea may promote metabolic dysfunction through cycles of intermittent hypoxia; proposed underlying pathophysiologic mechanisms include oxidative stress, sympathetic activation, and inflammation. SUMMARY: There is suggestive evidence, but independent associations between obstructive sleep apnea and metabolic syndrome or its components are not fully established because of the confounding effect of obesity. Large randomized interventional trials are needed to identify any cause-effect relationship. Long-term follow-up studies would help to clarify the role of treatment of sleep apnea in reducing cardio-metabolic morbidity. © 2007 Lippincott Williams & Wilkins, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/76931
ISSN
2015 Impact Factor: 3.079
2015 SCImago Journal Rankings: 1.397
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, JCen_HK
dc.contributor.authorIp, MSen_HK
dc.date.accessioned2010-09-06T07:26:27Z-
dc.date.available2010-09-06T07:26:27Z-
dc.date.issued2007en_HK
dc.identifier.citationCurrent Opinion In Pulmonary Medicine, 2007, v. 13 n. 6, p. 484-489en_HK
dc.identifier.issn1070-5287en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76931-
dc.description.abstractPURPOSE OF REVIEW: Patients with obstructive sleep apnea are often overweight or obese, and they frequently exhibit metabolic aberrations, collectively known as the metabolic syndrome, an established cardiovascular risk factor. We review recent data on the relationship between obstructive sleep apnea and metabolic syndrome or its components, including abdominal obesity, insulin resistance, hypertension, and dyslipidemia. RECENT FINDINGS: There is accumulating evidence for an independent association between obstructive sleep apnea and metabolic syndrome or its components. Recent epidemiologic and clinical data suggest a causal role of severe obstructive sleep apnea in development of hypertension, but findings for insulin resistance and dyslipidemia are controversial. Visceral obesity remains a confounding issue in analyses. Animal models and translational studies indicate that obstructive sleep apnea may promote metabolic dysfunction through cycles of intermittent hypoxia; proposed underlying pathophysiologic mechanisms include oxidative stress, sympathetic activation, and inflammation. SUMMARY: There is suggestive evidence, but independent associations between obstructive sleep apnea and metabolic syndrome or its components are not fully established because of the confounding effect of obesity. Large randomized interventional trials are needed to identify any cause-effect relationship. Long-term follow-up studies would help to clarify the role of treatment of sleep apnea in reducing cardio-metabolic morbidity. © 2007 Lippincott Williams & Wilkins, Inc.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.co-pulmonarymedicine.comen_HK
dc.relation.ispartofCurrent Opinion in Pulmonary Medicineen_HK
dc.rightsCurrent Opinion in Pulmonary Medicine. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - epidemiology - etiologyen_HK
dc.subject.meshMetabolic Syndrome X - epidemiology - etiology - metabolismen_HK
dc.subject.meshObesity - complications - epidemiologyen_HK
dc.subject.meshOxidative Stressen_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSleep Apnea, Obstructive - complications - epidemiology - metabolismen_HK
dc.subject.meshWorld Healthen_HK
dc.titleAn update on obstructive sleep apnea and the metabolic syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1070-5287&volume=13&spage=484&epage=489&date=2007&atitle=An+update+on+obstructive+sleep+apnea+and+the+metabolic+syndromeen_HK
dc.identifier.emailIp, MS:msmip@hku.hken_HK
dc.identifier.authorityIp, MS=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/MCP.0b013e3282efae9cen_HK
dc.identifier.pmid17901753-
dc.identifier.scopuseid_2-s2.0-34848898167en_HK
dc.identifier.hkuros149904en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34848898167&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue6en_HK
dc.identifier.spage484en_HK
dc.identifier.epage489en_HK
dc.identifier.isiWOS:000250363400004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLam, JC=25923453500en_HK
dc.identifier.scopusauthoridIp, MS=7102423259en_HK

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