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Article: Changes in cytokine production during pregnancy in patients with Graves' disease

TitleChanges in cytokine production during pregnancy in patients with Graves' disease
Authors
Issue Date2000
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/thy
Citation
Thyroid, 2000, v. 10 n. 8, p. 701-707 How to Cite?
AbstractIn order to investigate the role of type 1 and type 2 cytokines in the remission of Graves' disease (GD) during pregnancy, spontaneous and mitogen-stimulated production of interleukin (IL)-4, IL-6, IL-10, IL-12, interferon-γ (IFN-γ), and tumour necrosis factor-α (TNF-α) were measured by enzyme-linked immunospot assay of peripheral blood mononuclear cells from 10 pregnant women with GD, 8 healthy pregnant women, and 10 healthy nonpregnant women. Tests were performed in the first, second, and third trimesters of pregnancy and 10-17 weeks after delivery. IL-4 production was not affected greatly by normal or GD pregnancy, whereas IFN-γ production was suppressed throughout pregnancy but returned to normal levels after delivery in both controls and patients. IL-6 and TNF-α tended to be higher in GD pregnancy than normal pregnancy, especially in the second and third trimesters. Controls had raised IL-10 in the first trimester with a return to normal levels by the third trimester, whereas patients had raised levels throughout pregnancy. IL-12 levels were suppressed to a greater extent in control than Graves' pregnancy, especially during the second and third trimesters. Ratios of IL10:IL12 in phytohemaglutinin (PHA)-stimulated cultures were much lower in GD than normal pregnancy and cross-regulation of IL-10 and IL-12 may be deficient in GD.
Persistent Identifierhttp://hdl.handle.net/10722/76921
ISSN
2015 Impact Factor: 3.784
2015 SCImago Journal Rankings: 1.458
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJones, BMen_HK
dc.contributor.authorKwok, JSYen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2010-09-06T07:26:21Z-
dc.date.available2010-09-06T07:26:21Z-
dc.date.issued2000en_HK
dc.identifier.citationThyroid, 2000, v. 10 n. 8, p. 701-707en_HK
dc.identifier.issn1050-7256en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76921-
dc.description.abstractIn order to investigate the role of type 1 and type 2 cytokines in the remission of Graves' disease (GD) during pregnancy, spontaneous and mitogen-stimulated production of interleukin (IL)-4, IL-6, IL-10, IL-12, interferon-γ (IFN-γ), and tumour necrosis factor-α (TNF-α) were measured by enzyme-linked immunospot assay of peripheral blood mononuclear cells from 10 pregnant women with GD, 8 healthy pregnant women, and 10 healthy nonpregnant women. Tests were performed in the first, second, and third trimesters of pregnancy and 10-17 weeks after delivery. IL-4 production was not affected greatly by normal or GD pregnancy, whereas IFN-γ production was suppressed throughout pregnancy but returned to normal levels after delivery in both controls and patients. IL-6 and TNF-α tended to be higher in GD pregnancy than normal pregnancy, especially in the second and third trimesters. Controls had raised IL-10 in the first trimester with a return to normal levels by the third trimester, whereas patients had raised levels throughout pregnancy. IL-12 levels were suppressed to a greater extent in control than Graves' pregnancy, especially during the second and third trimesters. Ratios of IL10:IL12 in phytohemaglutinin (PHA)-stimulated cultures were much lower in GD than normal pregnancy and cross-regulation of IL-10 and IL-12 may be deficient in GD.en_HK
dc.languageengen_HK
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/thyen_HK
dc.relation.ispartofThyroiden_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThis is a copy of an article published in the [Thyroid] © [2000] [copyright Mary Ann Liebert, Inc.]; [Thyroid] is available online at: http://www.liebertonline.com.-
dc.subject.meshAdulten_HK
dc.subject.meshCytokines - biosynthesisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGraves Disease - immunologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInterferon-gamma - biosynthesisen_HK
dc.subject.meshInterleukin-10 - biosynthesisen_HK
dc.subject.meshInterleukin-12 - biosynthesisen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshPregnancy Complications - immunologyen_HK
dc.subject.meshReceptors, Thyrotropin - analysisen_HK
dc.subject.meshTumor Necrosis Factor-alpha - biosynthesisen_HK
dc.titleChanges in cytokine production during pregnancy in patients with Graves' diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1050-7256&volume=10&spage=701&epage=707&date=2000&atitle=Changes+in+cytokine+production+during+pregnancy+in+patients+with+Graves%27+diseaseen_HK
dc.identifier.emailKung, AWC:awckung@hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1089/10507250050137798-
dc.identifier.pmid11014316-
dc.identifier.scopuseid_2-s2.0-0033834303en_HK
dc.identifier.hkuros63411en_HK
dc.identifier.hkuros57749-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033834303&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue8en_HK
dc.identifier.spage701en_HK
dc.identifier.epage707en_HK
dc.identifier.isiWOS:000089373600012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJones, BM=7404958958en_HK
dc.identifier.scopusauthoridKwok, JSY=7006208874en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK

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