File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Mechanism of apoptosis induced by specific COX-2 inhibitor SC236 in gastric cancer cells

TitleMechanism of apoptosis induced by specific COX-2 inhibitor SC236 in gastric cancer cells
Authors
Issue Date2005
Citation
Zhonghua Zhong Liu Za Zhi [Chinese Journal Of Oncology]., 2005, v. 27 n. 3, p. 145-147 How to Cite?
AbstractOBJECTIVE: To investigate the underlying mechanism of apoptosis-inducing effect of a specific COX-2 inhibitor SC236 in gastric cancer cells. METHODS: Western blot analysis was used to measure apoptosis-related proteins, cytochrome c, and caspase-3. The catalytic activity of the caspases was measured using a colorimetric assay. RESULTS: Treatment of AGS gastric cancer cells with SC236 caused a significant elevation of the pro-apoptotic protein Bak, release of cytochrome c to the cytosol, and activation of caspase-3. A specific caspase-3 inhibitor, z-DEVD-fmk, blocked SC236-induced apoptosis. CONCLUSION: SC236 inhibits cell growth and induces apoptosis in gastric cancer cells at least partly through the up-regulation of Bak, stimulation of cytochrome c release, and activation of caspase-3.
Persistent Identifierhttp://hdl.handle.net/10722/76917
ISSN
2015 SCImago Journal Rankings: 0.190

 

DC FieldValueLanguage
dc.contributor.authorFan, XMen_HK
dc.contributor.authorZheng, FSen_HK
dc.contributor.authorLiu, HYen_HK
dc.contributor.authorMa, YHen_HK
dc.contributor.authorWong, BCen_HK
dc.date.accessioned2010-09-06T07:26:18Z-
dc.date.available2010-09-06T07:26:18Z-
dc.date.issued2005en_HK
dc.identifier.citationZhonghua Zhong Liu Za Zhi [Chinese Journal Of Oncology]., 2005, v. 27 n. 3, p. 145-147en_HK
dc.identifier.issn0253-3766en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76917-
dc.description.abstractOBJECTIVE: To investigate the underlying mechanism of apoptosis-inducing effect of a specific COX-2 inhibitor SC236 in gastric cancer cells. METHODS: Western blot analysis was used to measure apoptosis-related proteins, cytochrome c, and caspase-3. The catalytic activity of the caspases was measured using a colorimetric assay. RESULTS: Treatment of AGS gastric cancer cells with SC236 caused a significant elevation of the pro-apoptotic protein Bak, release of cytochrome c to the cytosol, and activation of caspase-3. A specific caspase-3 inhibitor, z-DEVD-fmk, blocked SC236-induced apoptosis. CONCLUSION: SC236 inhibits cell growth and induces apoptosis in gastric cancer cells at least partly through the up-regulation of Bak, stimulation of cytochrome c release, and activation of caspase-3.en_HK
dc.languageengen_HK
dc.relation.ispartofZhonghua zhong liu za zhi [Chinese journal of oncology].en_HK
dc.subject.meshAdenocarcinoma - metabolism - pathologyen_HK
dc.subject.meshApoptosis - drug effectsen_HK
dc.subject.meshCaspase 3en_HK
dc.subject.meshCaspases - metabolismen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshCyclooxygenase 2 Inhibitors - pharmacologyen_HK
dc.subject.meshCytochromes c - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshOligopeptides - pharmacologyen_HK
dc.subject.meshPoly(ADP-ribose) Polymerases - metabolismen_HK
dc.subject.meshPyrazoles - pharmacologyen_HK
dc.subject.meshStomach Neoplasms - metabolism - pathologyen_HK
dc.subject.meshSulfonamides - pharmacologyen_HK
dc.subject.meshbcl-2 Homologous Antagonist-Killer Protein - metabolismen_HK
dc.titleMechanism of apoptosis induced by specific COX-2 inhibitor SC236 in gastric cancer cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, BC:bcywong@hku.hken_HK
dc.identifier.authorityWong, BC=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid15946562-
dc.identifier.scopuseid_2-s2.0-33644563708en_HK
dc.identifier.hkuros99102en_HK
dc.identifier.volume27en_HK
dc.identifier.issue3en_HK
dc.identifier.spage145en_HK
dc.identifier.epage147en_HK
dc.identifier.scopusauthoridFan, XM=35187111100en_HK
dc.identifier.scopusauthoridZheng, FS=13403229100en_HK
dc.identifier.scopusauthoridLiu, HY=36072243300en_HK
dc.identifier.scopusauthoridMa, YH=13402622100en_HK
dc.identifier.scopusauthoridWong, BC=7402023340en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats