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Article: Leukaemic relapse of donor origin after allogeneic bone marrow transplantation from a donor who later developed bronchogenic carcinoma

TitleLeukaemic relapse of donor origin after allogeneic bone marrow transplantation from a donor who later developed bronchogenic carcinoma
Authors
Issue Date2002
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2002, v. 119 n. 3, p. 777-780 How to Cite?
AbstractDonor-derived leukaemia is exceptional after allogeneic bone marrow transplantation (BMT). A woman with chronic myeloid leukaemia received an allogeneic BMT from a human leucocyte antigen-identical brother. The donor, a 50-year-old non-smoker, died of squamous cell bronchogenic carcinoma 1 year later. At 4 years post BMT, the patient became BCR/ABL positive and relapsed with acute myeloid leukaemia, which was shown to be donor-derived cytogenetically and molecularly. Retrospective analysis showed that the donor-leukaemic clone had started to evolve as early as 6 months post BMT. Sequencing of p53 ruled out Li-Fraumeni syndrome. Predisposition to malignancy might be an underlying mechanism of donor-cell leukaemia.
Persistent Identifierhttp://hdl.handle.net/10722/76906
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorChan, ECen_HK
dc.contributor.authorSiu, LLPen_HK
dc.contributor.authorLau, TCMen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:26:11Z-
dc.date.available2010-09-06T07:26:11Z-
dc.date.issued2002en_HK
dc.identifier.citationBritish Journal Of Haematology, 2002, v. 119 n. 3, p. 777-780en_HK
dc.identifier.issn0007-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76906-
dc.description.abstractDonor-derived leukaemia is exceptional after allogeneic bone marrow transplantation (BMT). A woman with chronic myeloid leukaemia received an allogeneic BMT from a human leucocyte antigen-identical brother. The donor, a 50-year-old non-smoker, died of squamous cell bronchogenic carcinoma 1 year later. At 4 years post BMT, the patient became BCR/ABL positive and relapsed with acute myeloid leukaemia, which was shown to be donor-derived cytogenetically and molecularly. Retrospective analysis showed that the donor-leukaemic clone had started to evolve as early as 6 months post BMT. Sequencing of p53 ruled out Li-Fraumeni syndrome. Predisposition to malignancy might be an underlying mechanism of donor-cell leukaemia.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_HK
dc.relation.ispartofBritish Journal of Haematologyen_HK
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshAcute Diseaseen_HK
dc.subject.meshBone Marrow Transplantation - adverse effectsen_HK
dc.subject.meshCarcinoma, Bronchogenic - complicationsen_HK
dc.subject.meshFatal Outcomeen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive - therapyen_HK
dc.subject.meshLeukemia, Myeloid - etiology - geneticsen_HK
dc.subject.meshLung Neoplasms - complicationsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPedigreeen_HK
dc.subject.meshRecurrenceen_HK
dc.subject.meshSmoking - adverse effectsen_HK
dc.subject.meshTissue Donorsen_HK
dc.subject.meshTransplantation, Homologousen_HK
dc.titleLeukaemic relapse of donor origin after allogeneic bone marrow transplantation from a donor who later developed bronchogenic carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1048&volume=19&spage=777&epage=780&date=2002&atitle=Leukaemic+relapse+of+donor+origin+after+allogeneic+bone+marrow+transplantation+from+a+donor+who+later+developed+bronchogenic+carcinomaen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-2141.2002.03925.xen_HK
dc.identifier.pmid12437659-
dc.identifier.scopuseid_2-s2.0-0036436101en_HK
dc.identifier.hkuros77790en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036436101&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume119en_HK
dc.identifier.issue3en_HK
dc.identifier.spage777en_HK
dc.identifier.epage780en_HK
dc.identifier.isiWOS:000179283600031-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridChan, EC=7401994120en_HK
dc.identifier.scopusauthoridSiu, LLP=35574705900en_HK
dc.identifier.scopusauthoridLau, TCM=17341008600en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridMa, SK=37020910400en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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