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Article: Triple therapy with clarithromycin, omeprazole, and amoxicillin for eradication of Helicobacter pylori in duodenal ulcer patients in Asia and Africa

TitleTriple therapy with clarithromycin, omeprazole, and amoxicillin for eradication of Helicobacter pylori in duodenal ulcer patients in Asia and Africa
Authors
Issue Date2000
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 2000, v. 14 n. 11, p. 1529-1535 How to Cite?
AbstractBackground: Studies assessing the efficacy of triple therapy containing clarithromycin and amoxicillin for the eradication of Helicobacter pylori infection and healing of duodenal ulcers in Asian and African countries are limited. Aim: To determine the efficacy and safety of 1-week triple therapy with omeprazole, amoxicillin and clarithromycin for eradicating H. pylori infection in patients with active duodenal ulcer living in Asian and African regions. Methods: This was an open-label, multicentre study in 11 centres in Asia and Africa. Patients with endoscopy-proven duodenal ulcer and who were H. pylori-positive were treated with clarithromycin 500 mg, omeprazole 20 mg, and amoxicillin 1000 mg, all given twice daily for 7 days. Upper endoscopy was repeated at week 6 to check for ulcer healing and H. pylori status. Results: A total of 117 patients were recruited. H. pylori eradication rates were 85% by per protocol analysis and 80% by intention-to-treat analysis. Ulcer healing was found in 94% of subjects (per protocol analysis). Clinical success, measured by change of pre-treatment ulcer symptoms, was strongly supported by complete resolution or improvement in 100% of the evaluable patients (per protocol analysis). Since treatment-related adverse events, when present, were largely mild or moderate, the triple therapy regimen was considered safe. Conclusion: Seven-day triple therapy with omeprazole, amoxicillin, and clarithromycin was efficacious for treating Asian and African patients with duodenal ulcer disease associated with H. pylori infection, and the treatment regimen was well-tolerated.
Persistent Identifierhttp://hdl.handle.net/10722/76901
ISSN
2015 Impact Factor: 6.32
2015 SCImago Journal Rankings: 2.833
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorChang, FYen_HK
dc.contributor.authorAbid, Sen_HK
dc.contributor.authorAbbas, Zen_HK
dc.contributor.authorLin, BRen_HK
dc.contributor.authorVan Rensburg, Cen_HK
dc.contributor.authorChen, PCen_HK
dc.contributor.authorSchneider, Hen_HK
dc.contributor.authorSimjee, AEen_HK
dc.contributor.authorHamid, SSen_HK
dc.contributor.authorSeebaran, Aen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorDestefano, Men_HK
dc.contributor.authorLam, SKen_HK
dc.date.accessioned2010-09-06T07:26:08Z-
dc.date.available2010-09-06T07:26:08Z-
dc.date.issued2000en_HK
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2000, v. 14 n. 11, p. 1529-1535en_HK
dc.identifier.issn0269-2813en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76901-
dc.description.abstractBackground: Studies assessing the efficacy of triple therapy containing clarithromycin and amoxicillin for the eradication of Helicobacter pylori infection and healing of duodenal ulcers in Asian and African countries are limited. Aim: To determine the efficacy and safety of 1-week triple therapy with omeprazole, amoxicillin and clarithromycin for eradicating H. pylori infection in patients with active duodenal ulcer living in Asian and African regions. Methods: This was an open-label, multicentre study in 11 centres in Asia and Africa. Patients with endoscopy-proven duodenal ulcer and who were H. pylori-positive were treated with clarithromycin 500 mg, omeprazole 20 mg, and amoxicillin 1000 mg, all given twice daily for 7 days. Upper endoscopy was repeated at week 6 to check for ulcer healing and H. pylori status. Results: A total of 117 patients were recruited. H. pylori eradication rates were 85% by per protocol analysis and 80% by intention-to-treat analysis. Ulcer healing was found in 94% of subjects (per protocol analysis). Clinical success, measured by change of pre-treatment ulcer symptoms, was strongly supported by complete resolution or improvement in 100% of the evaluable patients (per protocol analysis). Since treatment-related adverse events, when present, were largely mild or moderate, the triple therapy regimen was considered safe. Conclusion: Seven-day triple therapy with omeprazole, amoxicillin, and clarithromycin was efficacious for treating Asian and African patients with duodenal ulcer disease associated with H. pylori infection, and the treatment regimen was well-tolerated.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_HK
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_HK
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshAmoxicillin - adverse effects - therapeutic useen_HK
dc.subject.meshAnti-Bacterial Agents - adverse effects - therapeutic useen_HK
dc.subject.meshAnti-Ulcer Agents - adverse effects - therapeutic useen_HK
dc.subject.meshClarithromycin - adverse effects - therapeutic useen_HK
dc.subject.meshDrug Therapy, Combinationen_HK
dc.subject.meshDuodenal Ulcer - complications - drug therapyen_HK
dc.subject.meshHelicobacter Infections - complications - drug therapyen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshOmeprazole - adverse effects - therapeutic useen_HK
dc.subject.meshPakistanen_HK
dc.subject.meshPenicillins - adverse effects - therapeutic useen_HK
dc.subject.meshSouth Africaen_HK
dc.subject.meshTaiwanen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleTriple therapy with clarithromycin, omeprazole, and amoxicillin for eradication of Helicobacter pylori in duodenal ulcer patients in Asia and Africaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0269-2813&volume=14&spage=1529&epage=1536&date=2000&atitle=Triple+therapy+with+clarithromycin,+omeprazole,+and+amoxicillin+for+eradication+of+Helicobacter+pylori+in+duodenal+ulcer+patients+in+Asia+and+Africaen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-2036.2000.00863.xen_HK
dc.identifier.pmid11069326en_HK
dc.identifier.scopuseid_2-s2.0-0033678775en_HK
dc.identifier.hkuros62018en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033678775&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1529en_HK
dc.identifier.epage1535en_HK
dc.identifier.isiWOS:000165274500018-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridChang, FY=7403648663en_HK
dc.identifier.scopusauthoridAbid, S=7006592817en_HK
dc.identifier.scopusauthoridAbbas, Z=35572268700en_HK
dc.identifier.scopusauthoridLin, BR=24481458100en_HK
dc.identifier.scopusauthoridVan Rensburg, C=23991405300en_HK
dc.identifier.scopusauthoridChen, PC=7408354703en_HK
dc.identifier.scopusauthoridSchneider, H=8403973500en_HK
dc.identifier.scopusauthoridSimjee, AE=7003712307en_HK
dc.identifier.scopusauthoridHamid, SS=35508866600en_HK
dc.identifier.scopusauthoridSeebaran, A=6602586354en_HK
dc.identifier.scopusauthoridZhang, J=8377949500en_HK
dc.identifier.scopusauthoridDestefano, M=6701567515en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK

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