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Conference Paper: Age-related osteoporosis in Chinese: an evaluation of the response of intestinal calcium absorption and calcitrophic hormones to dietary calcium deprivation.

TitleAge-related osteoporosis in Chinese: an evaluation of the response of intestinal calcium absorption and calcitrophic hormones to dietary calcium deprivation.
Authors
Issue Date1998
PublisherSpringer-Verlag London Ltd. The Journal's web site is located at http://link.springer.de/link/service/journals/00198/
Citation
Osteoporosis International, 1998, v. 8 n. 3 Suppl., p. 40 Abstract no. P093 How to Cite?
AbstractLow dietary calcium is a recognised risk for osteoporotic fractures. We evaluated the pathogenesis of age-related osteoporosis in a group of Chinese women with a mean calcium intake of 561±183 mg/day. When compared to young healthy controls, the osteoporotic subjects had negative calcium balance, raised urinary calcium excretion (0.63±O.47 vs 0.27±O.16 mol/mol, p
Persistent Identifierhttp://hdl.handle.net/10722/76899
ISSN
2015 Impact Factor: 3.445
2015 SCImago Journal Rankings: 1.460

 

DC FieldValueLanguage
dc.contributor.authorKung, AWCen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorChu, LWen_HK
dc.contributor.authorChiu, PKYen_HK
dc.date.accessioned2010-09-06T07:26:07Z-
dc.date.available2010-09-06T07:26:07Z-
dc.date.issued1998en_HK
dc.identifier.citationOsteoporosis International, 1998, v. 8 n. 3 Suppl., p. 40 Abstract no. P093en_HK
dc.identifier.issn0937-941Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/76899-
dc.description.abstractLow dietary calcium is a recognised risk for osteoporotic fractures. We evaluated the pathogenesis of age-related osteoporosis in a group of Chinese women with a mean calcium intake of 561±183 mg/day. When compared to young healthy controls, the osteoporotic subjects had negative calcium balance, raised urinary calcium excretion (0.63±O.47 vs 0.27±O.16 mol/mol, p<O.05) , low calc it rio I level (74±26 vs 108±33 pmol/l, p<0.02) and secondary hyperparathyroidism (3.67±1.54 vs 2.67±1.62 pmol/l, p<O.05). The fractional 45Ca absorption was around 61 % during unmodified diet in both osteoporotic subjects and in young controls which increased to 71 % and 68% respectively during low calcium diet. When subjected to graded dietary calcium deprivation, calcitriollevels failed to increase and urinary calcium excretion perSisted in the osteoporotic subjects. Supplementation of 1200mg calcium in the osteoporotic subjects was able to lower PTH level (2.27±1.09, vs 2.84±1.19 pmol/l, vs unmodified diet, p<0.005) but further suppressed serum calcitriollevel (60±21 vs 79±19 pmol/l, p<0.01) and decreased fractional 45Ca absorption (49±11% vs 61±18%, p<0.01), suggesting thatthis level of calcium intake was excessive and offset the potent compensatory ability of the intestine to absorb calcium. Based on the response of the calcitrophic hormones and fractional 45Ca absorption, a daily intake of 1000 - 1200mg calcium is probably adequate for the Chinese population.-
dc.languageengen_HK
dc.publisherSpringer-Verlag London Ltd. The Journal's web site is located at http://link.springer.de/link/service/journals/00198/en_HK
dc.relation.ispartofOsteoporosis Internationalen_HK
dc.titleAge-related osteoporosis in Chinese: an evaluation of the response of intestinal calcium absorption and calcitrophic hormones to dietary calcium deprivation.en_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0937-941X&volume=Suppl 3&spage=P093&epage=&date=1998&atitle=Age-related+osteoporosis+in+Chinese:+an+evaluation+of+the+response+of+intestinal+calcium+absorption+and+calcitrophic+hormones+to+dietary+calcium+deprivation.en_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.emailLuk, KDK: hrmoldk@hkucc.hku.hken_HK
dc.identifier.emailChu, LW: lwchu@HKUCC.hku.hken_HK
dc.identifier.emailChiu, PKY: pkychiu@hkucc.hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityChiu, PKY=rp00379en_HK
dc.identifier.doi10.1007/BF03262413-
dc.identifier.hkuros41427en_HK

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