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Article: A clinical evaluation of the International Lymphoma Study Group Classification of non-Hodgkin's lymphoma: a report of the Non-Hodgkin's Lymphoma Classification Project

TitleA clinical evaluation of the International Lymphoma Study Group Classification of non-Hodgkin's lymphoma: a report of the Non-Hodgkin's Lymphoma Classification Project
Authors
Issue Date1997
PublisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/
Citation
Blood, 1997, v. 88 n. 11, p. 3909-3918 How to Cite?
AbstractThe recognition of several new types of non-Hodgkin's lymphoma (NHL) in recent years has led to proposals for changing lymphoma classifications, including a new proposal put forth by the International Lymphoma Study Group (ILSG). However, the clinical significance of the new entities and the practical utility of this new proposal have not been studied. Therefore, we performed a clinical evaluation of the ILSG classification. A cohort of 1,403 cases of NHL was organized at nine study sites around the world and consisted of consecutive patients seen between 1988 and 1990 who were previously untreated. A detailed protocol for histologic and clinical analysis was followed at each site, and immunologic characterization as to T- or B-cell phenotype was required. Five expert hematopathologists visited the sites and each classified each case using the ILSG classification. A consensus diagnosis was also reached in each case, and each expert rereviewed a 20% random sample of the cases. Clinical correlations and survival analyses were then performed. A diagnosis of NHL was confirmed in 1,378 (98.2%) of the cases. The most common lymphoma types were diffuse large B-cell lymphoma (31%) and follicular lymphoma (22%), whereas the new entities comprised 21% of the cases. Diagnostic accuracy was at least 85% for most of the major lymphoma types, and reproducibility of the diagnosis was 85%. Immunophenotyping improved the diagnostic accuracy by 10% to 45% for a number of the major types. The clinical features of the new entities were distinctive. Both the histologic types and the patient characteristics as defined by the International Prognostic Index predicted for patient survival. In conclusion we found that the ILSG classification can be readily applied and identifies clinically distinctive types of NHL. However, for clinical application, prognostic factors as defined by the International Prognostic Index must be combined with the histologic diagnosis for appropriate clinical decisions.
Persistent Identifierhttp://hdl.handle.net/10722/76891
ISSN
2015 Impact Factor: 11.841
2015 SCImago Journal Rankings: 6.395

 

DC FieldValueLanguage
dc.contributor.authorAnderson, Jen_HK
dc.contributor.authorArmitage, JOen_HK
dc.contributor.authorBerger, Fen_HK
dc.contributor.authorCavalli, Fen_HK
dc.contributor.authorChan, WCen_HK
dc.contributor.authorClose, Jen_HK
dc.contributor.authorCoiffier, Ben_HK
dc.contributor.authorConnors, Jen_HK
dc.contributor.authorDiebold, Jen_HK
dc.contributor.authorGascoyne, Ren_HK
dc.contributor.authorHarris, Nen_HK
dc.contributor.authorHiddemann, Wen_HK
dc.contributor.authorHo, FCSen_HK
dc.contributor.authorJacobs, Pen_HK
dc.contributor.authorLiang, RHSen_HK
dc.contributor.authorLister, TAen_HK
dc.contributor.authorMacLennan, Ken_HK
dc.contributor.authorMuller-Hermelink, HKen_HK
dc.contributor.authorNathwani, BNen_HK
dc.contributor.authorNorton, Aen_HK
dc.contributor.authorOtt, Gen_HK
dc.contributor.authorPedrinis, Een_HK
dc.contributor.authorRoy, Pen_HK
dc.contributor.authorSchauer, Aen_HK
dc.contributor.authorWeisenburger, DDen_HK
dc.date.accessioned2010-09-06T07:26:02Z-
dc.date.available2010-09-06T07:26:02Z-
dc.date.issued1997en_HK
dc.identifier.citationBlood, 1997, v. 88 n. 11, p. 3909-3918en_HK
dc.identifier.issn0006-4971en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76891-
dc.description.abstractThe recognition of several new types of non-Hodgkin's lymphoma (NHL) in recent years has led to proposals for changing lymphoma classifications, including a new proposal put forth by the International Lymphoma Study Group (ILSG). However, the clinical significance of the new entities and the practical utility of this new proposal have not been studied. Therefore, we performed a clinical evaluation of the ILSG classification. A cohort of 1,403 cases of NHL was organized at nine study sites around the world and consisted of consecutive patients seen between 1988 and 1990 who were previously untreated. A detailed protocol for histologic and clinical analysis was followed at each site, and immunologic characterization as to T- or B-cell phenotype was required. Five expert hematopathologists visited the sites and each classified each case using the ILSG classification. A consensus diagnosis was also reached in each case, and each expert rereviewed a 20% random sample of the cases. Clinical correlations and survival analyses were then performed. A diagnosis of NHL was confirmed in 1,378 (98.2%) of the cases. The most common lymphoma types were diffuse large B-cell lymphoma (31%) and follicular lymphoma (22%), whereas the new entities comprised 21% of the cases. Diagnostic accuracy was at least 85% for most of the major lymphoma types, and reproducibility of the diagnosis was 85%. Immunophenotyping improved the diagnostic accuracy by 10% to 45% for a number of the major types. The clinical features of the new entities were distinctive. Both the histologic types and the patient characteristics as defined by the International Prognostic Index predicted for patient survival. In conclusion we found that the ILSG classification can be readily applied and identifies clinically distinctive types of NHL. However, for clinical application, prognostic factors as defined by the International Prognostic Index must be combined with the histologic diagnosis for appropriate clinical decisions.-
dc.languageengen_HK
dc.publisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/en_HK
dc.relation.ispartofBlooden_HK
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshEvaluation Studies as Topic-
dc.subject.meshLymphoma, Non-Hodgkin - classification-
dc.subject.meshMiddle Aged-
dc.titleA clinical evaluation of the International Lymphoma Study Group Classification of non-Hodgkin's lymphoma: a report of the Non-Hodgkin's Lymphoma Classification Projecten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-4971&volume=88&spage=3909&epage=3918&date=1997&atitle=A+clinical+evaluation+of+the+International+Lymphoma+Study+Group+Classification+of+non-Hodgkin%27s+lymphoma:+a+report+of+the+Non-Hodgkin%27s+Lymphoma+Classification+Projecten_HK
dc.identifier.emailHo, FCS: faithho@hkucc.hku.hken_HK
dc.identifier.emailLiang, RHS: rliang@hku.hken_HK
dc.identifier.authorityLiang, RHS=rp00345en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid9166827-
dc.identifier.scopuseid_2-s2.0-1842413105-
dc.identifier.hkuros23207en_HK

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