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Article: Acute myeloid leukemia relapsing as gynecomastia

TitleAcute myeloid leukemia relapsing as gynecomastia
Authors
Issue Date1999
PublisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lal
Citation
Leukemia And Lymphoma, 1999, v. 36 n. 1-2, p. 191-194 How to Cite?
AbstractGranulocytic sarcoma (GS) is an increasingly common relapse feature of acute myeloid leukemia (AML), late in the disease course or post bone marrow transplantation (BMT). Any solid organ can be affected, and there have been a number of reports of GS in breast tissue in female patients. We present a unique case of GS in a male AML patient, presenting as painless gynecomastia immediately before BMT at advanced disease. Aberrant expression of CD56 was found in the relapsed GS tissue but not in the original AML clone. Twelve months after allogeneic BMT, leukemia relapsed again in the same breast, with normal marrow morphology and full donor chimerism. The lesion failed to respond to donor lymphocyte infusion, chemotherapy and radiotherapy, and disseminated to other subcutaneous tissues.
Persistent Identifierhttp://hdl.handle.net/10722/76872
ISSN
2015 Impact Factor: 3.093
2015 SCImago Journal Rankings: 1.202
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorShek, WHen_HK
dc.contributor.authorChow, WCen_HK
dc.contributor.authorLiang, Ren_HK
dc.date.accessioned2010-09-06T07:25:49Z-
dc.date.available2010-09-06T07:25:49Z-
dc.date.issued1999en_HK
dc.identifier.citationLeukemia And Lymphoma, 1999, v. 36 n. 1-2, p. 191-194en_HK
dc.identifier.issn1042-8194en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76872-
dc.description.abstractGranulocytic sarcoma (GS) is an increasingly common relapse feature of acute myeloid leukemia (AML), late in the disease course or post bone marrow transplantation (BMT). Any solid organ can be affected, and there have been a number of reports of GS in breast tissue in female patients. We present a unique case of GS in a male AML patient, presenting as painless gynecomastia immediately before BMT at advanced disease. Aberrant expression of CD56 was found in the relapsed GS tissue but not in the original AML clone. Twelve months after allogeneic BMT, leukemia relapsed again in the same breast, with normal marrow morphology and full donor chimerism. The lesion failed to respond to donor lymphocyte infusion, chemotherapy and radiotherapy, and disseminated to other subcutaneous tissues.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lalen_HK
dc.relation.ispartofLeukemia and Lymphomaen_HK
dc.rightsLeukemia and Lymphoma. Copyright © Informa Healthcare.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAntigens, CD56 - analysisen_HK
dc.subject.meshBone Marrow Transplantationen_HK
dc.subject.meshGynecomastia - etiology - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukemia, Myeloid, Acute - complications - pathology - therapyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshRecurrenceen_HK
dc.titleAcute myeloid leukemia relapsing as gynecomastiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1042-8194&volume=36&spage=191&epage=194&date=2000&atitle=Acute+myeloid+leukemia+relapsing+as+gynecomastiaen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3109/10428199909145963-
dc.identifier.pmid10613464-
dc.identifier.scopuseid_2-s2.0-0033453257en_HK
dc.identifier.hkuros49592en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033453257&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage191en_HK
dc.identifier.epage194en_HK
dc.identifier.isiWOS:000084235400021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridMa, SK=37020910400en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridShek, WH=6701476327en_HK
dc.identifier.scopusauthoridChow, WC=21645013100en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK

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