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Article: Effect of environmental factors and gender on the heritability of bone mineral density and bone size

TitleEffect of environmental factors and gender on the heritability of bone mineral density and bone size
Authors
KeywordsBone density
Bone size
Environment
Gender
Heritability
Issue Date2006
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AHG
Citation
Annals Of Human Genetics, 2006, v. 70 n. 4, p. 428-438 How to Cite?
AbstractBone mineral density (BMD), a risk factor for osteoporosis, is believed to be under genetic control. The effect of environmental factors and gender on the heritability of BMD and bone size is ill-defined. In this study, heritability estimates (h2) were determined in 3,320 southern Chinese subjects from 1,019 families using the variance components model. The h2 for age, weight and height-adjusted BMD was 0.63-0.71 for females, and 0.74-0.79 for males; and for bone size, 0.44-0.64 for females and 0.32-0.86 for males. Adjustment for lifestyle factors including calcium and phytoestrogen intake, exercise, smoking and alcohol consumption altered the h2 differently in males and females. The proportion of variance in BMD and bone size explained by all covariates varied between skeletal sites, but was consistently greater in females than males. A significant gender difference was observed in the genetic variance of BMD and bone size at the hip but not the spine. In conclusion, a gender difference was observed in the degree of heritability of BMD and bone size at specific skeletal sites. Environmental influences contributed variably at different sites in the two sexes. © 2006 The Authors Journal compilation © 2006 University College London.
Persistent Identifierhttp://hdl.handle.net/10722/76848
ISSN
2015 Impact Factor: 1.889
2015 SCImago Journal Rankings: 1.191
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, MYMen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorPaterson, ADen_HK
dc.contributor.authorChan, Ven_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2010-09-06T07:25:34Z-
dc.date.available2010-09-06T07:25:34Z-
dc.date.issued2006en_HK
dc.identifier.citationAnnals Of Human Genetics, 2006, v. 70 n. 4, p. 428-438en_HK
dc.identifier.issn0003-4800en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76848-
dc.description.abstractBone mineral density (BMD), a risk factor for osteoporosis, is believed to be under genetic control. The effect of environmental factors and gender on the heritability of BMD and bone size is ill-defined. In this study, heritability estimates (h2) were determined in 3,320 southern Chinese subjects from 1,019 families using the variance components model. The h2 for age, weight and height-adjusted BMD was 0.63-0.71 for females, and 0.74-0.79 for males; and for bone size, 0.44-0.64 for females and 0.32-0.86 for males. Adjustment for lifestyle factors including calcium and phytoestrogen intake, exercise, smoking and alcohol consumption altered the h2 differently in males and females. The proportion of variance in BMD and bone size explained by all covariates varied between skeletal sites, but was consistently greater in females than males. A significant gender difference was observed in the genetic variance of BMD and bone size at the hip but not the spine. In conclusion, a gender difference was observed in the degree of heritability of BMD and bone size at specific skeletal sites. Environmental influences contributed variably at different sites in the two sexes. © 2006 The Authors Journal compilation © 2006 University College London.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AHGen_HK
dc.relation.ispartofAnnals of Human Geneticsen_HK
dc.rightsAnnals of Human Genetics. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectBone densityen_HK
dc.subjectBone sizeen_HK
dc.subjectEnvironmenten_HK
dc.subjectGenderen_HK
dc.subjectHeritabilityen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBone Density - geneticsen_HK
dc.subject.meshBone and Bones - anatomy & histologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenetic Linkageen_HK
dc.subject.meshHealth Behavioren_HK
dc.subject.meshHumansen_HK
dc.subject.meshInheritance Patternsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOsteoporosis - epidemiology - geneticsen_HK
dc.subject.meshSex Factorsen_HK
dc.titleEffect of environmental factors and gender on the heritability of bone mineral density and bone sizeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-4800&volume=70&spage=428&epage=38&date=2006&atitle=Effect+of+environmental+factors+and+gender+on+the+heritability+of+bone+mineral+density+and+bone+sizeen_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailChan, V: vnychana@hkucc.hku.hken_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityChan, V=rp00320en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1469-1809.2005.00242.xen_HK
dc.identifier.pmid16759177-
dc.identifier.scopuseid_2-s2.0-33744485242en_HK
dc.identifier.hkuros118428en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33744485242&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume70en_HK
dc.identifier.issue4en_HK
dc.identifier.spage428en_HK
dc.identifier.epage438en_HK
dc.identifier.isiWOS:000237811500002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridNg, MYM=8367886400en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridPaterson, AD=7202360951en_HK
dc.identifier.scopusauthoridChan, V=7202654865en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.citeulike671782-

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