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Article: T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation

TitleT-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation
Authors
Issue Date2003
PublisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.com
Citation
American Journal Of Clinical Pathology, 2003, v. 120 n. 4, p. 626-630 How to Cite?
AbstractA 39-year-old man with chronic myeloid leukemia in accelerated phase underwent allogeneic bone marrow transplantation (BMT). At 6 months after BMT, lymphocytosis (WBC count, 23,100/μL [23.1 × 109/L]; 80% (0.80) large granular lymphocytes [LGLs]) occurred. The LGLs were CD3+CD4-CD8+, with clonally rearranged T-cell receptor γ gene, and of donor origin, as shown by analysis of polymorphic microsatellite markers. Epstein-Barr virus was not present. The diagnosis, therefore, was consistent with T-cell large granular lymphocytic (T-LGL) leukemia. Corticosteroids controlled the LGL count, but progressive pancytopenia led to death 4 months later. Retrospective analysis showed that the T-LGL leukemia apparently had arisen as early as 3 months after BMT. The distinguishing features of this case included donor origin, neoplastic nature, and the aggressive fatal outcome.
Persistent Identifierhttp://hdl.handle.net/10722/76835
ISSN
2015 Impact Factor: 2.278
2015 SCImago Journal Rankings: 1.129
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorLam, CCKen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorPang, Aen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:25:25Z-
dc.date.available2010-09-06T07:25:25Z-
dc.date.issued2003en_HK
dc.identifier.citationAmerican Journal Of Clinical Pathology, 2003, v. 120 n. 4, p. 626-630en_HK
dc.identifier.issn0002-9173en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76835-
dc.description.abstractA 39-year-old man with chronic myeloid leukemia in accelerated phase underwent allogeneic bone marrow transplantation (BMT). At 6 months after BMT, lymphocytosis (WBC count, 23,100/μL [23.1 × 109/L]; 80% (0.80) large granular lymphocytes [LGLs]) occurred. The LGLs were CD3+CD4-CD8+, with clonally rearranged T-cell receptor γ gene, and of donor origin, as shown by analysis of polymorphic microsatellite markers. Epstein-Barr virus was not present. The diagnosis, therefore, was consistent with T-cell large granular lymphocytic (T-LGL) leukemia. Corticosteroids controlled the LGL count, but progressive pancytopenia led to death 4 months later. Retrospective analysis showed that the T-LGL leukemia apparently had arisen as early as 3 months after BMT. The distinguishing features of this case included donor origin, neoplastic nature, and the aggressive fatal outcome.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.comen_HK
dc.relation.ispartofAmerican Journal of Clinical Pathologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshBase Sequenceen_HK
dc.subject.meshBone Marrow Transplantation - adverse effectsen_HK
dc.subject.meshClone Cellsen_HK
dc.subject.meshDNA Mutational Analysisen_HK
dc.subject.meshDNA, Neoplasm - analysisen_HK
dc.subject.meshFatal Outcomeen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology - therapyen_HK
dc.subject.meshLeukemia, Prolymphocytic, T-Cell - etiology - genetics - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicrosatellite Repeatsen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshReceptors, Antigen, T-Cell, gamma-delta - geneticsen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshT-Lymphocyte Subsetsen_HK
dc.subject.meshTissue Donorsen_HK
dc.subject.meshTransplantation Chimeraen_HK
dc.subject.meshTransplantation, Homologousen_HK
dc.titleT-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9173&volume=120&spage=626&epage=30&date=2003&atitle=T-cell+large+granular+lymphocyte+leukemia+of+donor+origin+after+allogeneic+bone+marrow+transplantationen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1309/VA75-5A03-PVRV-9XDTen_HK
dc.identifier.pmid14560574-
dc.identifier.scopuseid_2-s2.0-0141655263en_HK
dc.identifier.hkuros87925en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141655263&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume120en_HK
dc.identifier.issue4en_HK
dc.identifier.spage626en_HK
dc.identifier.epage630en_HK
dc.identifier.isiWOS:000185585100016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridLam, CCK=16947291300en_HK
dc.identifier.scopusauthoridLie, AKW=7004510870en_HK
dc.identifier.scopusauthoridPang, A=7007044165en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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