File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Long-term effect of right ventricular pacing on myocardial perfusion and function

TitleLong-term effect of right ventricular pacing on myocardial perfusion and function
Authors
Issue Date1997
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jac
Citation
Journal Of The American College Of Cardiology, 1997, v. 29 n. 4, p. 744-749 How to Cite?
AbstractObjectives. The purpose of this study was to investigate the effect of long-term ventricular pacing on myocardial perfusion and function in patients receiving such pacing. Background. The long-term effect of ventricular pacing on myocardial perfusion and function in humans is unclear, although animal studies have suggested that it may be adverse. Methods. Forty-three patients with complete heart block and dual-chamber rate-adaptive (DDDR) pacing were studied. All underwent thallium-201 (Tl-201) exercise myocardial scintigraphy to assess myocardial perfusion and radionuclide ventriculography to determine left ventricular function and regional wall motion. Coronary angiography was also performed in patients with abnormal findings on Tl-201 study. Results. There was no significant difference in mean age, gender, percent ventricular pacing, pacing threshold, ventricular pacing output and metabolic equivalents on exercise testing between patients with or without perfusion defects on exercise Tl-201 scintigraphy. However, the duration of pacing tended to be longer in patients with than in those without perfusion defects (43.9 ± 49.7 vs. 20.1 ± 9.8 months, p = 0.05). Tl-201 perfusion defects were noted in 28 (65%) of 43 of patients (inferior 78% [n = 22], apical 67% [n = 17], septal 21% [n = 6], anterior 7% [n = 2], lateral 3% [n = 1]). Of 16 of 28 patients with abnormal Tl-201 findings who underwent coronary angiography, only 3 (19%) had significant coronary artery disease. Patients with an abnormal perfusion defect had a significantly lower left ventricular ejection fraction (48.5 ± 9.9% vs. 59.6 ± 8.9%, p < 0.001) and a higher percent of wall motion abnormalities (57% vs. 20%, p = 0.026), mainly over apical regions. Conclusions. Long-term right ventricular apical pacing resulted in a high incidence of myocardial perfusion defects that increased with the duration of pacing. These myocardial perfusion abnormalities were associated with apical wall motion abnormalities and impaired global left ventricular function.
Persistent Identifierhttp://hdl.handle.net/10722/76819
ISSN
2015 Impact Factor: 17.759
2015 SCImago Journal Rankings: 10.097
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, HFen_HK
dc.contributor.authorLau, CPen_HK
dc.date.accessioned2010-09-06T07:25:15Z-
dc.date.available2010-09-06T07:25:15Z-
dc.date.issued1997en_HK
dc.identifier.citationJournal Of The American College Of Cardiology, 1997, v. 29 n. 4, p. 744-749en_HK
dc.identifier.issn0735-1097en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76819-
dc.description.abstractObjectives. The purpose of this study was to investigate the effect of long-term ventricular pacing on myocardial perfusion and function in patients receiving such pacing. Background. The long-term effect of ventricular pacing on myocardial perfusion and function in humans is unclear, although animal studies have suggested that it may be adverse. Methods. Forty-three patients with complete heart block and dual-chamber rate-adaptive (DDDR) pacing were studied. All underwent thallium-201 (Tl-201) exercise myocardial scintigraphy to assess myocardial perfusion and radionuclide ventriculography to determine left ventricular function and regional wall motion. Coronary angiography was also performed in patients with abnormal findings on Tl-201 study. Results. There was no significant difference in mean age, gender, percent ventricular pacing, pacing threshold, ventricular pacing output and metabolic equivalents on exercise testing between patients with or without perfusion defects on exercise Tl-201 scintigraphy. However, the duration of pacing tended to be longer in patients with than in those without perfusion defects (43.9 ± 49.7 vs. 20.1 ± 9.8 months, p = 0.05). Tl-201 perfusion defects were noted in 28 (65%) of 43 of patients (inferior 78% [n = 22], apical 67% [n = 17], septal 21% [n = 6], anterior 7% [n = 2], lateral 3% [n = 1]). Of 16 of 28 patients with abnormal Tl-201 findings who underwent coronary angiography, only 3 (19%) had significant coronary artery disease. Patients with an abnormal perfusion defect had a significantly lower left ventricular ejection fraction (48.5 ± 9.9% vs. 59.6 ± 8.9%, p < 0.001) and a higher percent of wall motion abnormalities (57% vs. 20%, p = 0.026), mainly over apical regions. Conclusions. Long-term right ventricular apical pacing resulted in a high incidence of myocardial perfusion defects that increased with the duration of pacing. These myocardial perfusion abnormalities were associated with apical wall motion abnormalities and impaired global left ventricular function.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jacen_HK
dc.relation.ispartofJournal of the American College of Cardiologyen_HK
dc.rightsJournal of American College of Cardiology. Copyright © Elsevier Inc.en_HK
dc.subject.meshAgeden_HK
dc.subject.meshCardiac Pacing, Artificialen_HK
dc.subject.meshConstriction, Pathologicen_HK
dc.subject.meshCoronary Vessels - pathology - physiopathologyen_HK
dc.subject.meshExercise Testen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGated Blood-Pool Imagingen_HK
dc.subject.meshHeart - radionuclide imagingen_HK
dc.subject.meshHeart Block - pathology - physiopathology - radionuclide imaging - therapyen_HK
dc.subject.meshHeart Ventriclesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRegional Blood Flowen_HK
dc.subject.meshThallium Radioisotopes - diagnostic useen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshVentricular Function, Leften_HK
dc.titleLong-term effect of right ventricular pacing on myocardial perfusion and functionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0735-1097&volume=29&spage=744&epage=749&date=1997&atitle=Long-term+effect+of+right+ventricular+pacing+on+myocardial+perfusion+and+functionen_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0735-1097(96)00586-4en_HK
dc.identifier.pmid9091519en_HK
dc.identifier.scopuseid_2-s2.0-0030970211en_HK
dc.identifier.hkuros22916en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030970211&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue4en_HK
dc.identifier.spage744en_HK
dc.identifier.epage749en_HK
dc.identifier.isiWOS:A1997WN40500006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats