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Article: Factors affecting the therapeutic response of enalapril in treatment of post transplant erythrocytosis

TitleFactors affecting the therapeutic response of enalapril in treatment of post transplant erythrocytosis
Authors
KeywordsEnalapril
Erythrocytosis
Kidney transplantation
Issue Date1997
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEP
Citation
Nephrology, 1997, v. 3 n. 6, p. 569-571 How to Cite?
AbstractEnalapril was used for post transplant erythrocytosis (PTE) in 19 stable male hypertensive renal allograft recipients. Post transplant erythrocytosis was defined as haematocrit (Hct) >0.45 for 3 consecutive months. Dosage of enalapril was adjusted according to the blood pressure of individual patients and varied from 2.5 mg to 20 mg per day in divided doses. Patients' serum creatinine level, blood pressure and haematocrit were monitored. Therapeutic response was expressed as percentage drop in Hct (Δ%Hct). Factors affecting Δ%Hct was then determined. After 32 weeks of treatment, haematocrit fell from 0.495±0.021 to 0.396±0.053, which represented a 19.9% drop (paired Student's t-test, P<0.001). With multiple regression analysis, reciprocal of plasma creatinine (RCr) prior to enalapril therapy (B=3.40 ± 0.72, P<0.0005), dose of enalapril adjusted with bodyweight (B = -0.058±0.020, P<0.02, and pre-treatment haematocrit level (B = -1.90±0.71, P<0.02) were found to be independent factors affecting Δ%Hct. We concluded that the dosage of enalapril, renal allograft function and severity of erythrocytosis were the major factors affecting the therapeutic response of PTE by enalapril treatment.
Persistent Identifierhttp://hdl.handle.net/10722/76782
ISSN
2015 Impact Factor: 1.796
2015 SCImago Journal Rankings: 0.894
References

 

DC FieldValueLanguage
dc.contributor.authorSzeto, CCen_HK
dc.contributor.authorLui, SFen_HK
dc.contributor.authorWang, AYMen_HK
dc.contributor.authorLi, PKTen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-09-06T07:24:51Z-
dc.date.available2010-09-06T07:24:51Z-
dc.date.issued1997en_HK
dc.identifier.citationNephrology, 1997, v. 3 n. 6, p. 569-571en_HK
dc.identifier.issn1320-5358en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76782-
dc.description.abstractEnalapril was used for post transplant erythrocytosis (PTE) in 19 stable male hypertensive renal allograft recipients. Post transplant erythrocytosis was defined as haematocrit (Hct) >0.45 for 3 consecutive months. Dosage of enalapril was adjusted according to the blood pressure of individual patients and varied from 2.5 mg to 20 mg per day in divided doses. Patients' serum creatinine level, blood pressure and haematocrit were monitored. Therapeutic response was expressed as percentage drop in Hct (Δ%Hct). Factors affecting Δ%Hct was then determined. After 32 weeks of treatment, haematocrit fell from 0.495±0.021 to 0.396±0.053, which represented a 19.9% drop (paired Student's t-test, P<0.001). With multiple regression analysis, reciprocal of plasma creatinine (RCr) prior to enalapril therapy (B=3.40 ± 0.72, P<0.0005), dose of enalapril adjusted with bodyweight (B = -0.058±0.020, P<0.02, and pre-treatment haematocrit level (B = -1.90±0.71, P<0.02) were found to be independent factors affecting Δ%Hct. We concluded that the dosage of enalapril, renal allograft function and severity of erythrocytosis were the major factors affecting the therapeutic response of PTE by enalapril treatment.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEPen_HK
dc.relation.ispartofNephrologyen_HK
dc.subjectEnalaprilen_HK
dc.subjectErythrocytosisen_HK
dc.subjectKidney transplantationen_HK
dc.titleFactors affecting the therapeutic response of enalapril in treatment of post transplant erythrocytosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1320-5358&volume=3&spage=569&epage=572&date=1998&atitle=Factors+affecting+the+therapeutic+response+of+enalapril+in+treatment+of+post-transplant+erythrocytosisen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0031416678en_HK
dc.identifier.hkuros41503en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031416678&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issue6en_HK
dc.identifier.spage569en_HK
dc.identifier.epage571en_HK
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridSzeto, CC=35495407200en_HK
dc.identifier.scopusauthoridLui, SF=7102379144en_HK
dc.identifier.scopusauthoridWang, AYM=13606226000en_HK
dc.identifier.scopusauthoridLi, PKT=25928016800en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK

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