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Article: Thyrotoxic periodic paralysis and polymorphisms of sodium-potassium ATPase genes

TitleThyrotoxic periodic paralysis and polymorphisms of sodium-potassium ATPase genes
Authors
Issue Date2006
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664
Citation
Clinical Endocrinology, 2006, v. 64 n. 2, p. 158-161 How to Cite?
AbstractObjective: Thyrotoxic periodic paralysis (TPP) is a complication of hyperthyroidism association with recurrent, reversible episodes of muscle weakness. Increased sodium-potassium ATPase (Na/K-ATPase) pump activity is postulated to contribute to the hypokalaemic paralytic attacks in TPP. The aim of this study was to determine the genetic predisposition to TPP in relation to Na/K-ATPase genes. Design: A case-control association study. Patients: Ninety-nine male Chinese TPP patients were compared to 84 male Graves' disease (GD) patients without TPP and 100 normal male controls. Measurement: A total of 1500 base pairs upstream of the transcriptional start site of the five Na/K-ATPase genes that are expressed in the skeletal muscles, namely ATP1A1, ATP1A2, ATP1B1, ATP1B2 and ATP1B4, were sequenced in all subjects for mutations or polymorphisms. The single nucleotide polymorphisms (SNPs) of the coding regions of the five genes were also studied for association with TPP. Results: No mutations were detected in the 5′ regions of the five genes in any of the patients studied. There was no difference in the distribution of SNPs and SNP haplotypes in the upstream and coding region of these genes between the three groups of subjects. Conclusion: No association between the polymorphisms of ATP1A1, ATP1A2, ATP1B1, ATP1B2 and ATP1B4 genes and TPP could be detected. © 2006 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/76780
ISSN
2014 Impact Factor: 3.457
2014 SCImago Journal Rankings: 1.136
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKung, AWCen_HK
dc.contributor.authorLau, KSen_HK
dc.contributor.authorCheung, WMWen_HK
dc.contributor.authorChan, Ven_HK
dc.date.accessioned2010-09-06T07:24:50Z-
dc.date.available2010-09-06T07:24:50Z-
dc.date.issued2006en_HK
dc.identifier.citationClinical Endocrinology, 2006, v. 64 n. 2, p. 158-161en_HK
dc.identifier.issn0300-0664en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76780-
dc.description.abstractObjective: Thyrotoxic periodic paralysis (TPP) is a complication of hyperthyroidism association with recurrent, reversible episodes of muscle weakness. Increased sodium-potassium ATPase (Na/K-ATPase) pump activity is postulated to contribute to the hypokalaemic paralytic attacks in TPP. The aim of this study was to determine the genetic predisposition to TPP in relation to Na/K-ATPase genes. Design: A case-control association study. Patients: Ninety-nine male Chinese TPP patients were compared to 84 male Graves' disease (GD) patients without TPP and 100 normal male controls. Measurement: A total of 1500 base pairs upstream of the transcriptional start site of the five Na/K-ATPase genes that are expressed in the skeletal muscles, namely ATP1A1, ATP1A2, ATP1B1, ATP1B2 and ATP1B4, were sequenced in all subjects for mutations or polymorphisms. The single nucleotide polymorphisms (SNPs) of the coding regions of the five genes were also studied for association with TPP. Results: No mutations were detected in the 5′ regions of the five genes in any of the patients studied. There was no difference in the distribution of SNPs and SNP haplotypes in the upstream and coding region of these genes between the three groups of subjects. Conclusion: No association between the polymorphisms of ATP1A1, ATP1A2, ATP1B1, ATP1B2 and ATP1B4 genes and TPP could be detected. © 2006 Blackwell Publishing Ltd.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664en_HK
dc.relation.ispartofClinical Endocrinologyen_HK
dc.rightsClinical Endocrinology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshAdenosine Triphosphatases - geneticsen_HK
dc.subject.meshAdulten_HK
dc.subject.meshBase Sequenceen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshCation Transport Proteins - geneticsen_HK
dc.subject.meshCell Adhesion Molecules, Neuronal - geneticsen_HK
dc.subject.meshGene Frequencyen_HK
dc.subject.meshGraves Disease - geneticsen_HK
dc.subject.meshHaplotypesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypokalemic Periodic Paralysis - enzymology - geneticsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMutationen_HK
dc.subject.meshPolymorphism, Single Nucleotide - geneticsen_HK
dc.subject.meshProtein Subunits - geneticsen_HK
dc.subject.meshSodium-Potassium-Exchanging ATPase - geneticsen_HK
dc.titleThyrotoxic periodic paralysis and polymorphisms of sodium-potassium ATPase genesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-0664&volume=64&spage=158&epage=61&date=2006&atitle=Thyrotoxic+periodic+paralysis+and+polymorphisms+of+sodium-potassium+ATPase+genesen_HK
dc.identifier.emailKung, AWC:awckung@hku.hken_HK
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.identifier.authorityChan, V=rp00320en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2265.2005.02442.xen_HK
dc.identifier.pmid16430714en_HK
dc.identifier.scopuseid_2-s2.0-33645024086en_HK
dc.identifier.hkuros114783en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645024086&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume64en_HK
dc.identifier.issue2en_HK
dc.identifier.spage158en_HK
dc.identifier.epage161en_HK
dc.identifier.isiWOS:000234737300009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.scopusauthoridLau, KS=35205833900en_HK
dc.identifier.scopusauthoridCheung, WMW=7202743069en_HK
dc.identifier.scopusauthoridChan, V=7202654865en_HK
dc.identifier.citeulike472414-

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