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Article: Plasma phospholipid transfer protein activity and small, dense LDL in type 2 diabetes mellitus

TitlePlasma phospholipid transfer protein activity and small, dense LDL in type 2 diabetes mellitus
Authors
Issue Date2003
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ECI
Citation
European Journal Of Clinical Investigation, 2003, v. 33 n. 4, p. 301-306 How to Cite?
AbstractBackground: Phospholipid transfer protein (PLTP) and cholesteryl ester transfer protein (CETP) remodel circulating lipoproteins and play a role in the antiatherogenic reverse cholesterol transport pathway. The present study determined whether abnormalities in the LDL subfraction pattern in type 2 diabetic patients were related to changes in lipid transfer proteins. Methods: Low-density lipoprotein (LDL) subfractions were measured by density gradient ultracentrifugation and plasma PLTP and CETP activities by radiometric assays in 240 diabetic patients and 136 controls. Results: The diabetic patients had lower LDL-I (P < 0.001) and higher LDL-III concentrations than the controls (P < 0.001). Plasma PLTP activity was increased (P < 0.001) whereas no significant differences were seen in CETP activity. In the diabetic patients, small, dense LDL-III correlated with plasma triglyceride (r = 0.18, P < 0.01), HDL (r = -0.14, P < 0.05), PLTP (r = 0.29, P < 0.001) and CETP activity (r = 0.15, P < 0.05). Linear regression analysis showed that plasma PLTP activity, triglyceride and age were the major determinants of LDL-III concentration (r2 = 28%, P < 0.001). The univariate relationship between CETP and LDL-III was no longer significant after adjusting for PLTP activity. Conclusions: The increase in plasma PLTP activity was independently associated with small, dense LDL concentrations in type 2 diabetes. Hence, elevated PLTP activity might have both antiatherogenic and pro-atherogenic potential in these patients.
Persistent Identifierhttp://hdl.handle.net/10722/76771
ISSN
2015 Impact Factor: 2.687
2015 SCImago Journal Rankings: 1.255
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTan, KCBen_HK
dc.contributor.authorShiu, SWMen_HK
dc.contributor.authorWong, Yen_HK
dc.date.accessioned2010-09-06T07:24:45Z-
dc.date.available2010-09-06T07:24:45Z-
dc.date.issued2003en_HK
dc.identifier.citationEuropean Journal Of Clinical Investigation, 2003, v. 33 n. 4, p. 301-306en_HK
dc.identifier.issn0014-2972en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76771-
dc.description.abstractBackground: Phospholipid transfer protein (PLTP) and cholesteryl ester transfer protein (CETP) remodel circulating lipoproteins and play a role in the antiatherogenic reverse cholesterol transport pathway. The present study determined whether abnormalities in the LDL subfraction pattern in type 2 diabetic patients were related to changes in lipid transfer proteins. Methods: Low-density lipoprotein (LDL) subfractions were measured by density gradient ultracentrifugation and plasma PLTP and CETP activities by radiometric assays in 240 diabetic patients and 136 controls. Results: The diabetic patients had lower LDL-I (P < 0.001) and higher LDL-III concentrations than the controls (P < 0.001). Plasma PLTP activity was increased (P < 0.001) whereas no significant differences were seen in CETP activity. In the diabetic patients, small, dense LDL-III correlated with plasma triglyceride (r = 0.18, P < 0.01), HDL (r = -0.14, P < 0.05), PLTP (r = 0.29, P < 0.001) and CETP activity (r = 0.15, P < 0.05). Linear regression analysis showed that plasma PLTP activity, triglyceride and age were the major determinants of LDL-III concentration (r2 = 28%, P < 0.001). The univariate relationship between CETP and LDL-III was no longer significant after adjusting for PLTP activity. Conclusions: The increase in plasma PLTP activity was independently associated with small, dense LDL concentrations in type 2 diabetes. Hence, elevated PLTP activity might have both antiatherogenic and pro-atherogenic potential in these patients.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ECIen_HK
dc.relation.ispartofEuropean Journal of Clinical Investigationen_HK
dc.rightsEuropean Journal of Clinical Investigation. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshCarrier Proteins - blooden_HK
dc.subject.meshCholesterol Ester Transfer Proteinsen_HK
dc.subject.meshDiabetes Mellitus, Type 2 - blooden_HK
dc.subject.meshGlycoproteinsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLipoproteins, LDL - blooden_HK
dc.subject.meshMembrane Proteins - blooden_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPhospholipid Transfer Proteinsen_HK
dc.titlePlasma phospholipid transfer protein activity and small, dense LDL in type 2 diabetes mellitusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2972&volume=33&issue=4&spage=301&epage=6&date=2003&atitle=Plasma+Phospholipid+Transfer+Protein+Activity+And+Small,+Dense+Ldl+In+Type+2+Diabetes+Mellitus.en_HK
dc.identifier.emailTan, KCB:kcbtan@hku.hken_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-2362.2003.01132.xen_HK
dc.identifier.pmid12662160en_HK
dc.identifier.scopuseid_2-s2.0-0037395622en_HK
dc.identifier.hkuros78705en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037395622&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue4en_HK
dc.identifier.spage301en_HK
dc.identifier.epage306en_HK
dc.identifier.isiWOS:000181861400005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTan, KCB=8082703100en_HK
dc.identifier.scopusauthoridShiu, SWM=7005550652en_HK
dc.identifier.scopusauthoridWong, Y=24073787400en_HK

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