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Article: Predicting the outcome in non-Hodgkin lymphoma with molecular markers

TitlePredicting the outcome in non-Hodgkin lymphoma with molecular markers
Authors
Issue Date2007
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2007, v. 137 n. 4, p. 273-287 How to Cite?
AbstractThe World Health Organization classification divides non-Hodgkin lymphomas into B-cell, T-cell and natural killer-cell lymphomas. They are heterogeneous in epidemiology, histopathology and outcome. Clinical prognostic indices rely only on patient factors and staging. Molecular prognostic markers reflect the intrinsic lymphoma biology, measure tumour load and may provide novel therapeutic targets. Lymphomagenesis involves mutations, deletions or dysregulations of genes critical in the control of cell cycle and apoptosis, which are in turn prognostically important. Genome-wide gene expression profiling, either by allowing lymphomas to be classified according to different stages of lymphoid maturation, or by defining specific gene expression signatures, is also of prognostic significance. In lymphomas where viral infections of the neoplastic cells occur, quantification of viral copies is a surrogate marker for tumour load and hence prognosis. Molecular markers together with patient and clinicopathological features will provide more accurate prognostic models for risk stratification, in order to improve treatment outcome. © 2007 The Author.
Persistent Identifierhttp://hdl.handle.net/10722/76761
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:24:38Z-
dc.date.available2010-09-06T07:24:38Z-
dc.date.issued2007en_HK
dc.identifier.citationBritish Journal Of Haematology, 2007, v. 137 n. 4, p. 273-287en_HK
dc.identifier.issn0007-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76761-
dc.description.abstractThe World Health Organization classification divides non-Hodgkin lymphomas into B-cell, T-cell and natural killer-cell lymphomas. They are heterogeneous in epidemiology, histopathology and outcome. Clinical prognostic indices rely only on patient factors and staging. Molecular prognostic markers reflect the intrinsic lymphoma biology, measure tumour load and may provide novel therapeutic targets. Lymphomagenesis involves mutations, deletions or dysregulations of genes critical in the control of cell cycle and apoptosis, which are in turn prognostically important. Genome-wide gene expression profiling, either by allowing lymphomas to be classified according to different stages of lymphoid maturation, or by defining specific gene expression signatures, is also of prognostic significance. In lymphomas where viral infections of the neoplastic cells occur, quantification of viral copies is a surrogate marker for tumour load and hence prognosis. Molecular markers together with patient and clinicopathological features will provide more accurate prognostic models for risk stratification, in order to improve treatment outcome. © 2007 The Author.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_HK
dc.relation.ispartofBritish Journal of Haematologyen_HK
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshAntineoplastic Agents - therapeutic useen_HK
dc.subject.meshGene Expression Profilingen_HK
dc.subject.meshGenetic Markersen_HK
dc.subject.meshGenomeen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLymphoma, Non-Hodgkin - diagnosis - drug therapy - geneticsen_HK
dc.subject.meshRisk Assessmenten_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titlePredicting the outcome in non-Hodgkin lymphoma with molecular markersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1048&volume=137&issue=4&spage=273&epage=287&date=2007&atitle=Predicting+the+outcome+in+non-Hodgkin+lymphoma+with+molecular+markersen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2141.2007.06571.xen_HK
dc.identifier.pmid17408399-
dc.identifier.scopuseid_2-s2.0-34247549369en_HK
dc.identifier.hkuros137534en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247549369&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume137en_HK
dc.identifier.issue4en_HK
dc.identifier.spage273en_HK
dc.identifier.epage287en_HK
dc.identifier.isiWOS:000245938900001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.citeulike1256920-

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