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Article: Reactive oxidant species in asthma

TitleReactive oxidant species in asthma
Authors
Issue Date2006
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.co-pulmonarymedicine.com
Citation
Current Opinion In Pulmonary Medicine, 2006, v. 12 n. 1, p. 7-11 How to Cite?
AbstractPURPOSE OF REVIEW: This overview summarizes some recent studies on the balance of oxidants to antioxidants in patients with asthma. The aim of the review is to compare studies on the changes in oxidants/antioxidants in stable asthma or in acute exacerbation of asthma. RECENT FINDINGS: Our review of the recent literature in this field seems to indicate conflicting findings. Increased release of reactive oxygen species such as superoxide anion and hydrogen peroxide has been reported in exhaled breath condensates and from circulating granulocytes, and from the bronchoalveolar lavage cells of patients with asthma. In asthma, bronchial obstruction is associated with an increased spontaneous and stimulus-induced production of oxygen free radicals. The primary defense against reactive oxygen species is endogenous antioxidants, which are found to be altered in asthma. A marked decrease in plasma antioxidant capacity occurs. Superoxide dismutase activity is higher in erythrocytes and serum of asthmatic than in normal subjects and is diminished in cells from lavage and brushing samples of patients with asthma. Higher level of erythrocyte catalase activity has only been found in Chinese asthmatic patients while decreased glutathione peroxidase activity has been well documented. SUMMARY: Since there are considerable discrepancies in erythrocyte or plasma antioxidant enzyme activity in patients with asthma, the problem at this time is attempting to sort out these conflicting results and to find their roles in the pathogenesis of asthma. There is good evidence that antioxidant compounds may have a potential role in the treatment of asthma, especially of asthma exacerbation. © 2006 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/76714
ISSN
2015 Impact Factor: 3.079
2015 SCImago Journal Rankings: 1.397
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMak, JCWen_HK
dc.contributor.authorChanYeung, MMWen_HK
dc.date.accessioned2010-09-06T07:24:09Z-
dc.date.available2010-09-06T07:24:09Z-
dc.date.issued2006en_HK
dc.identifier.citationCurrent Opinion In Pulmonary Medicine, 2006, v. 12 n. 1, p. 7-11en_HK
dc.identifier.issn1070-5287en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76714-
dc.description.abstractPURPOSE OF REVIEW: This overview summarizes some recent studies on the balance of oxidants to antioxidants in patients with asthma. The aim of the review is to compare studies on the changes in oxidants/antioxidants in stable asthma or in acute exacerbation of asthma. RECENT FINDINGS: Our review of the recent literature in this field seems to indicate conflicting findings. Increased release of reactive oxygen species such as superoxide anion and hydrogen peroxide has been reported in exhaled breath condensates and from circulating granulocytes, and from the bronchoalveolar lavage cells of patients with asthma. In asthma, bronchial obstruction is associated with an increased spontaneous and stimulus-induced production of oxygen free radicals. The primary defense against reactive oxygen species is endogenous antioxidants, which are found to be altered in asthma. A marked decrease in plasma antioxidant capacity occurs. Superoxide dismutase activity is higher in erythrocytes and serum of asthmatic than in normal subjects and is diminished in cells from lavage and brushing samples of patients with asthma. Higher level of erythrocyte catalase activity has only been found in Chinese asthmatic patients while decreased glutathione peroxidase activity has been well documented. SUMMARY: Since there are considerable discrepancies in erythrocyte or plasma antioxidant enzyme activity in patients with asthma, the problem at this time is attempting to sort out these conflicting results and to find their roles in the pathogenesis of asthma. There is good evidence that antioxidant compounds may have a potential role in the treatment of asthma, especially of asthma exacerbation. © 2006 Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.co-pulmonarymedicine.comen_HK
dc.relation.ispartofCurrent Opinion in Pulmonary Medicineen_HK
dc.rightsCurrent Opinion in Pulmonary Medicine. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshAntioxidants - metabolismen_HK
dc.subject.meshAsthma - metabolismen_HK
dc.subject.meshFree Radical Scavengers - blooden_HK
dc.subject.meshHumansen_HK
dc.subject.meshOxidants - metabolismen_HK
dc.subject.meshOxidative Stressen_HK
dc.subject.meshReactive Oxygen Species - metabolismen_HK
dc.titleReactive oxidant species in asthmaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1070-5287&volume=12&issue=1&spage=7&epage=11&date=2006&atitle=Reactive+oxidant+species+in+asthma.en_HK
dc.identifier.emailMak, JCW:judymak@hku.hken_HK
dc.identifier.authorityMak, JCW=rp00352en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/01.mcp.0000198067.50457.71en_HK
dc.identifier.pmid16357572-
dc.identifier.scopuseid_2-s2.0-33646835914en_HK
dc.identifier.hkuros121764en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646835914&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue1en_HK
dc.identifier.spage7en_HK
dc.identifier.epage11en_HK
dc.identifier.isiWOS:000234383400002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMak, JCW=7103323094en_HK
dc.identifier.scopusauthoridChanYeung, MMW=54790582200en_HK

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