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Article: Update on medical and surgical management of intracerebral hemorrhage

TitleUpdate on medical and surgical management of intracerebral hemorrhage
Authors
Issue Date2007
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/rrct/index.htm
Citation
Reviews On Recent Clinical Trials, 2007, v. 2 n. 3, p. 174-181 How to Cite?
AbstractIntracerebral hemorrhage (ICH) accounts for 15% of all strokes in the US and Europe and 20% to 30% in Asian populations. ICH is associated with a higher morbidity, disability and mortality than ischemic strokes. Primary ICH originates from spontaneous rupture of small arteries and arterioles previously damaged by chronic hypertension or amyloid angiopathy. Secondary ICH is associated with underlying vascular abnormalities or other pathologies. Manifestation is acute with focal neurological signs and features of raised intracranial pressure. Despite our improved understanding of the pathophysiology of hematoma expansion and edema formation, management is primarily supportive, and outcomes remain poor. A recently published report has confirmed that there is no overall benefit from early surgery when compared with initial conservative treatment. In contrast, treatment with recombinant activated factor VII within 4 hours of onset limits hematoma growth at 24 hours, and reduces mortality and improves functional outcomes at 90 days. Several ICH scoring methods have recently been proposed for better prediction of outcome. These scoring methods may be useful in selecting suitable patients for clinical trials. Microbleeds are commonly seen on magnetic resonance imaging. Further studies are awaited to clarify the association between microbleeds and the future risk of ICH. © 2007 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/76695
ISSN
2015 SCImago Journal Rankings: 0.366
References

 

DC FieldValueLanguage
dc.contributor.authorTak Fai Cheung, Ren_HK
dc.date.accessioned2010-09-06T07:23:57Z-
dc.date.available2010-09-06T07:23:57Z-
dc.date.issued2007en_HK
dc.identifier.citationReviews On Recent Clinical Trials, 2007, v. 2 n. 3, p. 174-181en_HK
dc.identifier.issn1574-8871en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76695-
dc.description.abstractIntracerebral hemorrhage (ICH) accounts for 15% of all strokes in the US and Europe and 20% to 30% in Asian populations. ICH is associated with a higher morbidity, disability and mortality than ischemic strokes. Primary ICH originates from spontaneous rupture of small arteries and arterioles previously damaged by chronic hypertension or amyloid angiopathy. Secondary ICH is associated with underlying vascular abnormalities or other pathologies. Manifestation is acute with focal neurological signs and features of raised intracranial pressure. Despite our improved understanding of the pathophysiology of hematoma expansion and edema formation, management is primarily supportive, and outcomes remain poor. A recently published report has confirmed that there is no overall benefit from early surgery when compared with initial conservative treatment. In contrast, treatment with recombinant activated factor VII within 4 hours of onset limits hematoma growth at 24 hours, and reduces mortality and improves functional outcomes at 90 days. Several ICH scoring methods have recently been proposed for better prediction of outcome. These scoring methods may be useful in selecting suitable patients for clinical trials. Microbleeds are commonly seen on magnetic resonance imaging. Further studies are awaited to clarify the association between microbleeds and the future risk of ICH. © 2007 Bentham Science Publishers Ltd.en_HK
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/rrct/index.htmen_HK
dc.relation.ispartofReviews on Recent Clinical Trialsen_HK
dc.subject.meshBrain Edema - etiologyen_HK
dc.subject.meshCerebral Hemorrhage - drug therapy - etiology - surgeryen_HK
dc.subject.meshClinical Protocolsen_HK
dc.subject.meshCoagulants - therapeutic useen_HK
dc.subject.meshFactor VIIa - therapeutic useen_HK
dc.subject.meshHematoma - etiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIntracranial Hypertension - diagnosis - prevention & controlen_HK
dc.subject.meshNeurologic Examinationen_HK
dc.subject.meshRecombinant Proteinsen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleUpdate on medical and surgical management of intracerebral hemorrhageen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1574-8871&volume=2&spage=174&epage=181&date=2007&atitle=Update+on+medical+and+surgical+management+of+intracerebral+hemorrhageen_HK
dc.identifier.emailTak Fai Cheung, R:rtcheung@hku.hken_HK
dc.identifier.authorityTak Fai Cheung, R=rp00434en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/157488707781662751en_HK
dc.identifier.pmid18474003-
dc.identifier.scopuseid_2-s2.0-35048839665en_HK
dc.identifier.hkuros146907en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35048839665&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.issue3en_HK
dc.identifier.spage174en_HK
dc.identifier.epage181en_HK
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridTak Fai Cheung, R=7202397498en_HK

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