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Article: Mannose-binding lectin and susceptibility to infection in Chinese patients with systemic lupus erythematosus

TitleMannose-binding lectin and susceptibility to infection in Chinese patients with systemic lupus erythematosus
Authors
KeywordsComplement deficiency
Hospitalization
Immunocompromised host
Immunosuppressant
Infection
Issue Date2007
PublisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.com
Citation
Journal Of Rheumatology, 2007, v. 34 n. 6, p. 1270-1276 How to Cite?
AbstractObjective. To test the hypothesis that low serum mannose-binding lectin (MBL) levels, as a result of the single-nucleotide polymorphisms in the promoter region (-221 X/Y) and exon 1 (codon 54 A/B) of the MBL2 gene, predispose to infection in Chinese patients with systemic lupus erythematosus (SLE). Methods. Two hundred forty-five patients with SLE were prospectively followed for the development of major infective episodes that required hospitalization and antibiotic treatment during 1992-2005. MBL genotypes were determined by polymerase chain reaction and serum MBL levels were measured by ELISA. Results. In total, 254 major infections developed in 130 patients. Serum MBL levels were shown to correlate inversely with the number of bacterial infections (r = -0.13, p = 0.03). The distribution of MBL genotypes was similar in patients with and without major infection (p = 0.84). Patients with major infection also had more major lupus exacerbations that required daily prednisolone dose ≥ 15 mg. Logistic regression showed that log MBL level (odds ratio 0.516, 95% confidence interval 0.305-0.873; p = 0.01) and major lupus exacerbation (OR 1.382, 95% CI 1.154-1.654; p < 0.001) were independent risk factors to major bacterial infection after adjustment for age and disease duration. Multiple regression analysis showed an increase in risk of bacterial infection by 34.2% for every decrease in serum MBL level by one log, and by 22.8% for each increase in number of major lupus exacerbations. Conclusion. Low serum MBL level predisposes Chinese patients with SLE to more major infections, in particular bacterial ones.
Persistent Identifierhttp://hdl.handle.net/10722/76683
ISSN
2014 Impact Factor: 3.187
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMok, MYen_HK
dc.contributor.authorIp, WKEen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorLo, Yen_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T07:23:50Z-
dc.date.available2010-09-06T07:23:50Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Rheumatology, 2007, v. 34 n. 6, p. 1270-1276en_HK
dc.identifier.issn0315-162Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/76683-
dc.description.abstractObjective. To test the hypothesis that low serum mannose-binding lectin (MBL) levels, as a result of the single-nucleotide polymorphisms in the promoter region (-221 X/Y) and exon 1 (codon 54 A/B) of the MBL2 gene, predispose to infection in Chinese patients with systemic lupus erythematosus (SLE). Methods. Two hundred forty-five patients with SLE were prospectively followed for the development of major infective episodes that required hospitalization and antibiotic treatment during 1992-2005. MBL genotypes were determined by polymerase chain reaction and serum MBL levels were measured by ELISA. Results. In total, 254 major infections developed in 130 patients. Serum MBL levels were shown to correlate inversely with the number of bacterial infections (r = -0.13, p = 0.03). The distribution of MBL genotypes was similar in patients with and without major infection (p = 0.84). Patients with major infection also had more major lupus exacerbations that required daily prednisolone dose ≥ 15 mg. Logistic regression showed that log MBL level (odds ratio 0.516, 95% confidence interval 0.305-0.873; p = 0.01) and major lupus exacerbation (OR 1.382, 95% CI 1.154-1.654; p < 0.001) were independent risk factors to major bacterial infection after adjustment for age and disease duration. Multiple regression analysis showed an increase in risk of bacterial infection by 34.2% for every decrease in serum MBL level by one log, and by 22.8% for each increase in number of major lupus exacerbations. Conclusion. Low serum MBL level predisposes Chinese patients with SLE to more major infections, in particular bacterial ones.en_HK
dc.languageengen_HK
dc.publisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.comen_HK
dc.relation.ispartofJournal of Rheumatologyen_HK
dc.subjectComplement deficiencyen_HK
dc.subjectHospitalizationen_HK
dc.subjectImmunocompromised hosten_HK
dc.subjectImmunosuppressanten_HK
dc.subjectInfectionen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBacterial Infections - ethnology - immunologyen_HK
dc.subject.meshChinaen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshDisease Susceptibility - ethnology - immunologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expression Regulationen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunocompromised Host - immunologyen_HK
dc.subject.meshImmunosuppressive Agents - therapeutic useen_HK
dc.subject.meshLupus Erythematosus, Systemic - blood - complications - drug therapy - ethnologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMannose-Binding Lectin - blood - geneticsen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMutation - geneticsen_HK
dc.subject.meshOpportunistic Infections - genetics - immunologyen_HK
dc.subject.meshPhenotypeen_HK
dc.subject.meshPolymorphism, Single Nucleotideen_HK
dc.subject.meshProspective Studiesen_HK
dc.titleMannose-binding lectin and susceptibility to infection in Chinese patients with systemic lupus erythematosusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0315-162X&volume=34&spage=1270&epage=6&date=2007&atitle=Mannose-binding+lectin+and+susceptibility+to+Infection+in+Chinese+patients+with+systemic+lupus+erythematosusen_HK
dc.identifier.emailMok, MY:temy@hkucc.hku.hken_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid17552055en_HK
dc.identifier.scopuseid_2-s2.0-34250206014en_HK
dc.identifier.hkuros128415en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250206014&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1270en_HK
dc.identifier.epage1276en_HK
dc.identifier.isiWOS:000247116600012-
dc.publisher.placeCanadaen_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.scopusauthoridIp, WKE=35083568800en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridLo, Y=35148230000en_HK
dc.identifier.scopusauthoridWong, WHS=13310222200en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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