Article: Mannose-binding lectin and susceptibility to infection in Chinese patients with systemic lupus erythematosus

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TitleMannose-binding lectin and susceptibility to infection in Chinese patients with systemic lupus erythematosus
AuthorsMok, MY2 3
Ip, WKE1 2
Lau, CS2
Lo, Y2 4
Wong, WHS2 3
Lau, YL2 3
KeywordsComplement deficiency
Hospitalization
Immunocompromised host
Immunosuppressant
Infection
Issue Date2007
PublisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.com
CitationJournal Of Rheumatology, 2007, v. 34 n. 6, p. 1270-1276 [How to Cite?]
AbstractObjective. To test the hypothesis that low serum mannose-binding lectin (MBL) levels, as a result of the single-nucleotide polymorphisms in the promoter region (-221 X/Y) and exon 1 (codon 54 A/B) of the MBL2 gene, predispose to infection in Chinese patients with systemic lupus erythematosus (SLE). Methods. Two hundred forty-five patients with SLE were prospectively followed for the development of major infective episodes that required hospitalization and antibiotic treatment during 1992-2005. MBL genotypes were determined by polymerase chain reaction and serum MBL levels were measured by ELISA. Results. In total, 254 major infections developed in 130 patients. Serum MBL levels were shown to correlate inversely with the number of bacterial infections (r = -0.13, p = 0.03). The distribution of MBL genotypes was similar in patients with and without major infection (p = 0.84). Patients with major infection also had more major lupus exacerbations that required daily prednisolone dose ≥ 15 mg. Logistic regression showed that log MBL level (odds ratio 0.516, 95% confidence interval 0.305-0.873; p = 0.01) and major lupus exacerbation (OR 1.382, 95% CI 1.154-1.654; p < 0.001) were independent risk factors to major bacterial infection after adjustment for age and disease duration. Multiple regression analysis showed an increase in risk of bacterial infection by 34.2% for every decrease in serum MBL level by one log, and by 22.8% for each increase in number of major lupus exacerbations. Conclusion. Low serum MBL level predisposes Chinese patients with SLE to more major infections, in particular bacterial ones.
ISSN0315-162X
2011 Impact Factor: 3.695
2011 SCImago Journal Rankings: 0.321
ISI Accession Number IDWOS:000247116600012
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorMok, MY
dc.contributor.authorIp, WKE
dc.contributor.authorLau, CS
dc.contributor.authorLo, Y
dc.contributor.authorWong, WHS
dc.contributor.authorLau, YL
dc.date.accessioned2010-09-06T07:23:50Z
dc.date.available2010-09-06T07:23:50Z
dc.date.issued2007
dc.description.abstractObjective. To test the hypothesis that low serum mannose-binding lectin (MBL) levels, as a result of the single-nucleotide polymorphisms in the promoter region (-221 X/Y) and exon 1 (codon 54 A/B) of the MBL2 gene, predispose to infection in Chinese patients with systemic lupus erythematosus (SLE). Methods. Two hundred forty-five patients with SLE were prospectively followed for the development of major infective episodes that required hospitalization and antibiotic treatment during 1992-2005. MBL genotypes were determined by polymerase chain reaction and serum MBL levels were measured by ELISA. Results. In total, 254 major infections developed in 130 patients. Serum MBL levels were shown to correlate inversely with the number of bacterial infections (r = -0.13, p = 0.03). The distribution of MBL genotypes was similar in patients with and without major infection (p = 0.84). Patients with major infection also had more major lupus exacerbations that required daily prednisolone dose ≥ 15 mg. Logistic regression showed that log MBL level (odds ratio 0.516, 95% confidence interval 0.305-0.873; p = 0.01) and major lupus exacerbation (OR 1.382, 95% CI 1.154-1.654; p < 0.001) were independent risk factors to major bacterial infection after adjustment for age and disease duration. Multiple regression analysis showed an increase in risk of bacterial infection by 34.2% for every decrease in serum MBL level by one log, and by 22.8% for each increase in number of major lupus exacerbations. Conclusion. Low serum MBL level predisposes Chinese patients with SLE to more major infections, in particular bacterial ones.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Rheumatology, 2007, v. 34 n. 6, p. 1270-1276 [How to Cite?]
dc.identifier.epage1276
dc.identifier.hkuros128415
dc.identifier.isiWOS:000247116600012
dc.identifier.issn0315-162X
2011 Impact Factor: 3.695
2011 SCImago Journal Rankings: 0.321
dc.identifier.issue6
dc.identifier.openurl
dc.identifier.pmid17552055
dc.identifier.scopuseid_2-s2.0-34250206014
dc.identifier.spage1270
dc.identifier.urihttp://hdl.handle.net/10722/76683
dc.identifier.volume34
dc.languageeng
dc.publisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.com
dc.publisher.placeCanada
dc.relation.ispartofJournal of Rheumatology
dc.relation.referencesReferences in Scopus
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBacterial Infections - ethnology - immunology
dc.subject.meshChina
dc.subject.meshCohort Studies
dc.subject.meshDisease Susceptibility - ethnology - immunology
dc.subject.meshFemale
dc.subject.meshGene Expression Regulation
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshImmunocompromised Host - immunology
dc.subject.meshImmunosuppressive Agents - therapeutic use
dc.subject.meshLupus Erythematosus, Systemic - blood - complications - drug therapy - ethnology
dc.subject.meshMale
dc.subject.meshMannose-Binding Lectin - blood - genetics
dc.subject.meshMiddle Aged
dc.subject.meshMutation - genetics
dc.subject.meshOpportunistic Infections - genetics - immunology
dc.subject.meshPhenotype
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshProspective Studies
dc.subjectComplement deficiency
dc.subjectHospitalization
dc.subjectImmunocompromised host
dc.subjectImmunosuppressant
dc.subjectInfection
dc.titleMannose-binding lectin and susceptibility to infection in Chinese patients with systemic lupus erythematosus
dc.typeArticle
Author Affiliations
  1. Massachusetts General Hospital
  2. The University of Hong Kong
  3. Queen Mary Hospital Hong Kong
  4. Division of Rheumatology