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Article: Mannose-binding lectin and susceptibility to infection in Chinese patients with systemic lupus erythematosus
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TitleMannose-binding lectin and susceptibility to infection in Chinese patients with systemic lupus erythematosus
 
AuthorsMok, MY3 2
Ip, WKE2 1
Lau, CS2
Lo, Y2 4
Wong, WHS2 3
Lau, YL2 3
 
KeywordsComplement deficiency
Hospitalization
Immunocompromised host
Immunosuppressant
Infection
 
Issue Date2007
 
PublisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.com
 
CitationJournal Of Rheumatology, 2007, v. 34 n. 6, p. 1270-1276 [How to Cite?]
 
AbstractObjective. To test the hypothesis that low serum mannose-binding lectin (MBL) levels, as a result of the single-nucleotide polymorphisms in the promoter region (-221 X/Y) and exon 1 (codon 54 A/B) of the MBL2 gene, predispose to infection in Chinese patients with systemic lupus erythematosus (SLE). Methods. Two hundred forty-five patients with SLE were prospectively followed for the development of major infective episodes that required hospitalization and antibiotic treatment during 1992-2005. MBL genotypes were determined by polymerase chain reaction and serum MBL levels were measured by ELISA. Results. In total, 254 major infections developed in 130 patients. Serum MBL levels were shown to correlate inversely with the number of bacterial infections (r = -0.13, p = 0.03). The distribution of MBL genotypes was similar in patients with and without major infection (p = 0.84). Patients with major infection also had more major lupus exacerbations that required daily prednisolone dose ≥ 15 mg. Logistic regression showed that log MBL level (odds ratio 0.516, 95% confidence interval 0.305-0.873; p = 0.01) and major lupus exacerbation (OR 1.382, 95% CI 1.154-1.654; p < 0.001) were independent risk factors to major bacterial infection after adjustment for age and disease duration. Multiple regression analysis showed an increase in risk of bacterial infection by 34.2% for every decrease in serum MBL level by one log, and by 22.8% for each increase in number of major lupus exacerbations. Conclusion. Low serum MBL level predisposes Chinese patients with SLE to more major infections, in particular bacterial ones.
 
ISSN0315-162X
2013 Impact Factor: 3.173
 
ISI Accession Number IDWOS:000247116600012
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorMok, MY
 
dc.contributor.authorIp, WKE
 
dc.contributor.authorLau, CS
 
dc.contributor.authorLo, Y
 
dc.contributor.authorWong, WHS
 
dc.contributor.authorLau, YL
 
dc.date.accessioned2010-09-06T07:23:50Z
 
dc.date.available2010-09-06T07:23:50Z
 
dc.date.issued2007
 
dc.description.abstractObjective. To test the hypothesis that low serum mannose-binding lectin (MBL) levels, as a result of the single-nucleotide polymorphisms in the promoter region (-221 X/Y) and exon 1 (codon 54 A/B) of the MBL2 gene, predispose to infection in Chinese patients with systemic lupus erythematosus (SLE). Methods. Two hundred forty-five patients with SLE were prospectively followed for the development of major infective episodes that required hospitalization and antibiotic treatment during 1992-2005. MBL genotypes were determined by polymerase chain reaction and serum MBL levels were measured by ELISA. Results. In total, 254 major infections developed in 130 patients. Serum MBL levels were shown to correlate inversely with the number of bacterial infections (r = -0.13, p = 0.03). The distribution of MBL genotypes was similar in patients with and without major infection (p = 0.84). Patients with major infection also had more major lupus exacerbations that required daily prednisolone dose ≥ 15 mg. Logistic regression showed that log MBL level (odds ratio 0.516, 95% confidence interval 0.305-0.873; p = 0.01) and major lupus exacerbation (OR 1.382, 95% CI 1.154-1.654; p < 0.001) were independent risk factors to major bacterial infection after adjustment for age and disease duration. Multiple regression analysis showed an increase in risk of bacterial infection by 34.2% for every decrease in serum MBL level by one log, and by 22.8% for each increase in number of major lupus exacerbations. Conclusion. Low serum MBL level predisposes Chinese patients with SLE to more major infections, in particular bacterial ones.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Rheumatology, 2007, v. 34 n. 6, p. 1270-1276 [How to Cite?]
 
dc.identifier.epage1276
 
dc.identifier.hkuros128415
 
dc.identifier.isiWOS:000247116600012
 
dc.identifier.issn0315-162X
2013 Impact Factor: 3.173
 
dc.identifier.issue6
 
dc.identifier.openurl
 
dc.identifier.pmid17552055
 
dc.identifier.scopuseid_2-s2.0-34250206014
 
dc.identifier.spage1270
 
dc.identifier.urihttp://hdl.handle.net/10722/76683
 
dc.identifier.volume34
 
dc.languageeng
 
dc.publisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.com
 
dc.publisher.placeCanada
 
dc.relation.ispartofJournal of Rheumatology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdolescent
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshBacterial Infections - ethnology - immunology
 
dc.subject.meshChina
 
dc.subject.meshCohort Studies
 
dc.subject.meshDisease Susceptibility - ethnology - immunology
 
dc.subject.meshFemale
 
dc.subject.meshGene Expression Regulation
 
dc.subject.meshGenotype
 
dc.subject.meshHumans
 
dc.subject.meshImmunocompromised Host - immunology
 
dc.subject.meshImmunosuppressive Agents - therapeutic use
 
dc.subject.meshLupus Erythematosus, Systemic - blood - complications - drug therapy - ethnology
 
dc.subject.meshMale
 
dc.subject.meshMannose-Binding Lectin - blood - genetics
 
dc.subject.meshMiddle Aged
 
dc.subject.meshMutation - genetics
 
dc.subject.meshOpportunistic Infections - genetics - immunology
 
dc.subject.meshPhenotype
 
dc.subject.meshPolymorphism, Single Nucleotide
 
dc.subject.meshProspective Studies
 
dc.subjectComplement deficiency
 
dc.subjectHospitalization
 
dc.subjectImmunocompromised host
 
dc.subjectImmunosuppressant
 
dc.subjectInfection
 
dc.titleMannose-binding lectin and susceptibility to infection in Chinese patients with systemic lupus erythematosus
 
dc.typeArticle
 
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<contributor.author>Ip, WKE</contributor.author>
<contributor.author>Lau, CS</contributor.author>
<contributor.author>Lo, Y</contributor.author>
<contributor.author>Wong, WHS</contributor.author>
<contributor.author>Lau, YL</contributor.author>
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Author Affiliations
  1. Massachusetts General Hospital
  2. The University of Hong Kong
  3. Queen Mary Hospital Hong Kong
  4. Division of Rheumatology