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Article: The role of trisomy 8 in the pathogenesis of chronic eosinophilic leukemia

TitleThe role of trisomy 8 in the pathogenesis of chronic eosinophilic leukemia
Authors
Keywords+8
Chronic eosinophilic leukemia
Cytogenetics
Eosinophilic chloroma
FISH
Issue Date1999
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 1999, v. 30 n. 7, p. 864-868 How to Cite?
AbstractA case of chronic eosinophilic leukemia (CEL) manifesting as spinal cord compression by an extradural eosinophilic chloroma in a 32-year-old Chinese man was presented, who subsequently developed extramedullary transformation at the skin and then peritoneal cavity. Cytogenetic study of bone marrow cells at diagnosis showed a clonal karyotypic abnormality of trisomy 8 (+8), which on fluorescence in situ hybridization (FISH) was shown to be present in a clone of abnormal eosinophils, hence showing the neoplastic nature of the eosinophilic proliferation. There was another population of abnormal eosinophils that did not show +8. At blastic transformation, all blast cells in ascitic fluid were shown by FISH to harbor +8. These findings suggest that +8 in this case may have arisen from clonal evolution and is not the primary genetic event in leukemogenesis, but +8 most probably imparts a further survival advantage to the clone responsible for subsequent blastic transformation.
Persistent Identifierhttp://hdl.handle.net/10722/76677
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, SKen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorShek, TWHen_HK
dc.contributor.authorWan, TSKen_HK
dc.contributor.authorChow, EYDen_HK
dc.contributor.authorChan, LCen_HK
dc.date.accessioned2010-09-06T07:23:45Z-
dc.date.available2010-09-06T07:23:45Z-
dc.date.issued1999en_HK
dc.identifier.citationHuman Pathology, 1999, v. 30 n. 7, p. 864-868en_HK
dc.identifier.issn0046-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76677-
dc.description.abstractA case of chronic eosinophilic leukemia (CEL) manifesting as spinal cord compression by an extradural eosinophilic chloroma in a 32-year-old Chinese man was presented, who subsequently developed extramedullary transformation at the skin and then peritoneal cavity. Cytogenetic study of bone marrow cells at diagnosis showed a clonal karyotypic abnormality of trisomy 8 (+8), which on fluorescence in situ hybridization (FISH) was shown to be present in a clone of abnormal eosinophils, hence showing the neoplastic nature of the eosinophilic proliferation. There was another population of abnormal eosinophils that did not show +8. At blastic transformation, all blast cells in ascitic fluid were shown by FISH to harbor +8. These findings suggest that +8 in this case may have arisen from clonal evolution and is not the primary genetic event in leukemogenesis, but +8 most probably imparts a further survival advantage to the clone responsible for subsequent blastic transformation.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_HK
dc.relation.ispartofHuman Pathologyen_HK
dc.subject+8en_HK
dc.subjectChronic eosinophilic leukemiaen_HK
dc.subjectCytogeneticsen_HK
dc.subjectEosinophilic chloromaen_HK
dc.subjectFISHen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAscites - genetics - pathologyen_HK
dc.subject.meshChromosomes, Human, Pair 8en_HK
dc.subject.meshChronic Diseaseen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypereosinophilic Syndrome - genetics - metabolism - radiographyen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshIn Situ Hybridization, Fluorescenceen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPeritoneal Diseases - metabolism - pathologyen_HK
dc.subject.meshSkin Diseases - metabolism - pathologyen_HK
dc.subject.meshTomography, X-Ray Computeden_HK
dc.subject.meshTrisomyen_HK
dc.subject.meshTumor Markers, Biological - metabolismen_HK
dc.titleThe role of trisomy 8 in the pathogenesis of chronic eosinophilic leukemiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=30&spage=864&epage=868&date=1999&atitle=The+role+of+trisomy+8+in+the+pathogenesis+of+chronic+eosinophilic+leukemiaen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0046-8177(99)90149-1en_HK
dc.identifier.pmid10414507en_HK
dc.identifier.scopuseid_2-s2.0-0032783222en_HK
dc.identifier.hkuros41653en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032783222&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue7en_HK
dc.identifier.spage864en_HK
dc.identifier.epage868en_HK
dc.identifier.isiWOS:000081361600019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMa, SK=9042504200en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridShek, TWH=7005479861en_HK
dc.identifier.scopusauthoridWan, TSK=25623981600en_HK
dc.identifier.scopusauthoridChow, EYD=7102595571en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK

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